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脈管グループ
  Gリーダー 研究テーマ 主な論文

主な論文

ORIGINAL ARTICLE(英語)
  1. Shimamura M, Nakagami H, Sata M, Takaoka M, Azuma J, Kiomy Osako M, Koriyama H, Kurinami H, Wakayama K, Miyake T, Morishita R. Unique remodeling processes after vascular injury in intracranial arteries: analysis using a novel mouse model. J Cereb Blood Flow Metab. 2013 Aug; 33(8):1153-9.
  2. Makino H, Aoki M, Hashiya N, Yamasaki K, Azuma J, Sawa Y, Kaneda Y, Ogihara T, Morishita R. Long-term follow-up evaluation of results from clinical trial using hepatocyte growth factor gene to treat severe peripheral arterial disease. Arterioscler Thromb Vasc Biol. 2012 Oct;32(10):2503-9.
  3. Shimizu K, Taniyama Y, Sanada F, Iwabayashi M, Azuma J, Iekushi K, Rakugi H, and Morishita R. Hepatocyte growth factor inhibits LPS-induced oxidative stress via epithelial growth factor receptor degradation. Arterioscler Thromb Vasc Biol. 2012 Oct;32(10):2503-9.
  4. Iwabayashi M, Taniyama Y, Sanada F, Azuma J, Iekushi K, Okayama K, Chatterjee A, Rakugi H, Morishita R. Inhibition of Lp(a)-induced functional impairment of endothelial cells and endothelial progenitor cells by hepatocyte growth factor. Biochem Biophys Res Commun. 2012 Jun 22;423(1):79-84.
  5. Yokoi T, Azuma J, Nakade Y, Sanada F, Iekushi K, Yoshika M, Masuda M, Komiyama Y, Taniyama Y, Masaki H, Morishita R, Takahashi H. Comparison between two calcium antagonists: blood pressure reduction and renal effects in hypertensive patients with type 2 diabetes. IEMAMC 2012 in press
  6. Okayama K*, Azuma J*, Dosaka N*, Iekushi K, Sanada F, Kusunoki H, Iwabayashi M, Rakugi H, Taniyama Y, and Morishita R. Hepatocyte Growth Factor Reduces Cardiac Fibrosis by Inhibiting Endothelial-Mesenchymal Transition. Hypertension. 2012 May;59(5):958-65. *equal contribution
    [selected for cover]
  7. Maegdefessel L, Azuma J, Toh R, Deng A, Merk DR, Raiesdana A, Leeper NJ, Raaz U, Schoelmerich AM, McConnell MV, Dalman RL, Spin JM, Tsao PS. MicroRNA-21 blocks abdominal aortic aneurysm development and nicotine-augmented expansion. Sci Transl Med. 2012 Feb 22;4(122):122ra22.
  8. Maegdefessel L, Azuma J, Toh R, Merk DR, Deng A, Chin JT, Raaz U, Schoelmerich AM, Raiesdana A, Leeper NJ, McConnell MV, Dalman RL, Spin JM, Tsao PS. Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development. J Clin Invest. 2012 Jan 24. pii: 61598. doi: 10.1172/JCI61598.
  9. Kusunoki H, Taniyama Y, Azuma J, Iekushi K, Sanada F, Iwabayashi M, Otsu R, Okayama K, Rakugi H, Morishita R; Evidence of Contribution of perioxisome-proliferator activated receptor gamma; activation to organ protective actions of telmisartan independent of angiotensin II type 1 receptor blockade. Hypertension. 2012 Feb;59(2):308-16.
  10. Iwabayashi M, Taniyama Y, Sanada F, Azuma J, Iekushi K, Kusunoki H, Chatterjee A, Okayama K, Rakugi H and Morishita R; Role of serotoin in angiogenesis: induction of angiogenesis via endothelial 5-HT1B/Akt/eNOS pathway by sarpogrelate in diabetic mice. Atherosclerosis. 2012 Feb;220(2):337-42.
  11. Saatchi S, Azuma J, Wanchoo N, Smith SJ, Yock PG, Taylor C, . Tsao PS. Three-Dimensional Microstructural Changes in Murine Abdominal Aortic Aneurysms Quantified Using Immunofluorescent Array Tomography, Journal of Histochemistry & Cytochemistry, J Histochem Cytochem. 2012 Feb;60(2):97-109.
    [selected for cover]
  12. Asagami T, Belanoff JK, Azuma J, Blasey CM, Clark RD, Tsao PS; Selective Glucocorticoid Receptor (GR-II) Antagonist Reduces Body Weight Gain in Mice. Journal of Nutrition and Metabolism. 2011 : 235389; 4
  13. Zhao H, Azuma J, Kalish F, Wong JR, Stevenson DK; Maternal Heme Oxygenase 1 Regulates Placental Vasculature Development via Angiogenic Factors in Mice. Biol Reprod. 2011 Nov;85(5):1005-12.
  14. Spin JM, Hsu M, Azuma J, Tedesco MM, Dyer JS PhD, Maegdefessel L, Dalman RL, Tsao PS; Transcriptional Profiling and Network Analysis of the Murine Angiotensin II-Induced Abdominal Aortic Aneurysm. Physiol Genomics. 2011 Sep 8;43(17):993-1003.
  15. Iekushi K, Taniyama Y, Kusunoki H, Azuma J, Sanada F, Okayama K, Iwabayashi M, Koibuchi N, Rakugi H, Morishita R; Hepatocyte growth factor attenuates TGF-b- angiotensin II crosstalk through the inhibition of PTEN/Akt pathway, Hypertension. 2011 Aug;58(2):190-6
  16. *Azuma J, Maegdefessel L, Kitagawa T, Dalman RL, McConnell MV, Tsao PS. Assessment of Elastase-induced Murine Abdominal Aortic Aneurysms: Comparison of Ultrasound Imaging with in situ Video Microscopy. J Biomed Biotechnol. 2011: 2011 252141
  17. Morishita R, Makino H, Aoki M, Hashiya N, Yamasaki K, Azuma J, Taniyama Y, Sawa Y, Kaneda Y, Ogihara T. Phase I/IIa Clinical Trial of Therapeutic Angiogenesis Using Hepatocyte Growth Factor Gene Transfer to Treat Critical Limb Ischemia. Arterioscler Thromb Vasc Biol. 2011; 31 (3): 713-20
  18. Goergen CJ, Azuma J, Barr KN, Magdefessel L, Kallop DY, Gogineni A, Grewall A, Weimer RM, Connolly AJ, Dalman RL, Taylor CA, Tsao PS, Greve JM. Influences of Aortic Motion and Curvature on Vessel Expansion in Murine Experimental Aneurysms. Arterioscler Thromb Vasc Biol. 2011 Feb;31(2):270-9.
  19. Yue P, Jin H, Xu S, Aillaud M, Deng AC, Azuma J, Kundu RK, Reaven GM, Quertermous T, Tsao PS. Apelin Decreases Lipolysis via Gq, Gi, and AMPK-Dependent Mechanisms. Endocrinology. 2011; 152 (1): 59-68
  20. Leeper NJ, Raiesdana A, Kojima Y, Chun HJ, Azuma J, Maegdefessel L, Kundu RK, Quertermous T, Tsao PS, Spin JM. MicroRNA-26a is a novel regulator of vascular smooth muscle cell function. J Cell Physiol. 2011; 226 (4): 1035-43
  21. Iekushi K, Taniyama Y, Azuma J, Sanada F, Kusunoki H, Yokoi T, Koibuchi N, Okayama K, Rakugi H, Morishita R. Hepatocyte growth factor attenuates renal fibrosis through TGF-β1 suppression by apoptosis of myofibroblasts. J Hypertens. 2010; 28 (12): 2454-61
  22. Dua MM, Miyama N, Azuma J, Schultz GM, Sho M, Morser J, Dalman RL. Hyperglycemia modulates plasminogen activator inhibitor-1 expression and aortic diameter in experimental aortic aneurysm disease. Surgery. 2010; 148 (2): 429-35
  23. Yue P, Jin H, Aillaud M, Deng AC, Azuma J, Asagami T, Kundu RK, Reaven GM, Quertermous T, Tsao PS. Apelin is necessary for the maintenance of insulin sensitivity. Am J Physiol Endocrinol Metab. 2010; 298 (1): E59-67
  24. Saatchi S, Wanchoo N, Azuma J, Smith SJ, Tsao PS, Yock PG, Taylor CA. The Use of Immunofluorescent Array Tomography to Study the Three-Dimensional Microstructure of Murine Blood Vessels. Cell Mol Bioeng. 2012; 4(2):311-323.
  25. Sanada F, Taniyama Y, Azuma J, Iekushi K, Dosaka N, Yokoi T, Koibuchi N, Kusunoki H, Aizawa Y, Morishita R. Hepatocyte growth factor, but not vascular endothelial growth factor, attenuates angiotensin II-induced endothelial progenitor cell senescence. Hypertension. 2009; 53 (1): 77-82
  26. *Azuma J, Asagami T, Dalman R, Tsao PS. Creation of murine experimental abdominal aortic aneurysms with elastase. J Vis Exp. 2009 Jul 23;(29). pii: 1280. doi: 10.3791/1280.
  27. Sanada F, Taniyama Y, Iekushi K, Azuma J, Okayama K, Kusunoki H, Koibuchi N, Doi T, Aizawa Y, Morishita R. Negative action of hepatocyte growth factor/c-Met system on angiotensin II signaling via ligand-dependent epithelial growth factor receptor degradation mechanism in vascular smooth muscle cells. Circ Res. 2009 Sep 25;105(7):667-75
  28. Iekushi K, Taniyama Y, Azuma J, Katsuragi N, Dosaka N, Sanada F, Koibuchi N, Nagao K, Ogihara T, Morishita R. Novel mechanisms of valsartan on the treatment of acute myocardial infarction through inhibition of the antiadhesion molecule periostin. Hypertension. 2007; 49 (6): 1409-14
  29. *Azuma J, Taniyama Y, Takeya Y, Iekushi K, Aoki M, Dosaka N, Matsumoto K, Nakamura T, Ogihara T, Morishita R. Angiogenic and antifibrotic actions of hepatocyte growth factor improve cardiac dysfunction in porcine ischemic cardiomyopathy. Gene Ther. 2006; 13 (16): 1206-13
  30. Taniyama Y, Shimamura M, Sato N, Tomita N, Endoh M, Azuma J, Iekushi K, Kaneda Y, Ogihara T, Morishita R; Modification of Plasmid DNA-based Gene Transfer into Central Nerve System. AFSUMB 2004 1274; 159-163
  31. Taniyama Y, Shimamura M, Sato N, Tomita N, Endoh M, Azuma J, Iekushi K, Kaneda Y, Ogihara T, Morishita R; Modification of Plasmid DNA-based Gene Transfer with microbubulles. ISTU; 2004, 1-5
  32. Morishita R, Aoki M, Hashiya N, Makino H, Yamasaki K, Azuma J, Sawa Y, Matsuda H, Kaneda Y, Ogihara T. Safety evaluation of clinical gene therapy using hepatocyte growth factor to treat peripheral arterial disease by therapeutic angiogenesis. Hypertension 2004; 44 (2) 203-209.
  33. Makino H, Aoki M, Hashiya N, Yamasaki K, Hiraoka K, Shimizu H, Azuma J, Kurinami H, Ogihara T, Morishita R. Increase in peripheral blood flow by intravenous administration of prostaglandin E1 in patients with peripheral arterial disease, accompanied by up-regulation of hepatocyte growth factor (HGF). Hypertension Research 2003;27:85-91
  34. Tsuchikane E, Otsuji S, Awata N, Azuma J, Nakaoka Y, Uesugi H, Kobayashi T, Sakurai M, Kobayashi T. Impact of pre-stent plaque debulking for chronic coronary total occlusions on restenosis reduction. J Invasive Cardiol. 2001; 13 (8): 584-9
REVIEW(英語)
  1. Maegdefessel L, Azuma J, Tsao PS; MicroRNA-29b regulation of abdominal aortic aneurysm development, Trends Cardiovasc Med. 2013 Jul 18
  2. Taniyama Y, Azuma J, Kunugiza Y, Iekushi K, Rakugi H, Morishita R; Therapeutic option of plasmid-DNA based gene transfer, Curr Top in Med Chem 2012 in press
  3. Taniyama Y, Azuma J, Iekushi K, Sanada F, Iwabayashi M, Kusunoki H, Okayama K, Otsu R, Rakugi H, Morishita R; The HGF/c-Met receptor system under pathological conditions, IEMAMC 2012 in press
  4. Taniyama Y, Takeya Y, Azuma J, Iekushi K, Sanada F, Kusunoki H, Okayama K, Koibuchi N , Rakugi H and Morishita R; HGF as angiogenic factor and therapeutic approach, Current Signal Transduction Therapy 2011; 2: 221-227(7)
  5. Maegdefessel L, Spin JM, Azuma J, Tsao PS. New options with dabigatran etexilate in anticoagulant therapy. Vasc Health Risk Manag. 2010 May 25;6:339-49. Review.
  6. Maegdefessel L, Azuma J, Tsao PS. Modern role for clopidogrel in management of atrial fibrillation and stroke reduction. Vasc Health Risk Manag. 2010 Mar 3;6:95-103.
  7. Morishita R, Aoki M, Hashiya N, Yamasaki K, Kurinami H, Shimizu S, Makino H, Takesya Y, Azuma J, Ogihara T. herapeutic angiogenesis using hepatocyte growth factor (HGF). Curr Gene Ther. 2004 Jun;4(2):199-206. Review.
REVIEW(日本語)
  1. Azuma J, Taniyama Y, Iwabayashi M, Morishita R. Anti-hypertensive treatment of patients with metabolic syndrome. Cardioangiology, 73(6):690-697, 2013
  2. Azuma J, Iekushi K, Iwabayashi M, Taniyama Y, Morishita R. The role of MicroRNA in aging. Japanese Journal of Genetics, vol.50, no.1, 2013 Jan. 9-15
  3. [Therapeutic angiogenesis for coronary artery].
    Taniyama Y, Azuma J, Iwabayashi M, Morishita R, Rakugi H. Nippon Rinsho. 2011 Sep;69 Suppl 7:74-9.
  4. Taniyama Y, Morishita R, Makino H, Azuma J, Ogihara T. Gene therapy in congestive heart failure. Nippon Rinsho. 2005 Dec;63 Suppl 12:594-7. Review.
  5. Taniyama Y, Morishita R, Azuma J, Iekushi K. Therapeutic angiogenesis for ischemic heart disease induced by gene transfer. Nippon Rinsho. 2005 Dec;63 Suppl 12:588-93. Review.
  6. Taniyama Y, Morishita R, Azuma J, Iekushi K, Ogihara T. Gene therapy for diabetic microangiopathy. Nippon Rinsho. 2005 Jun;63 Suppl 6:153-8. Review.
  7. AZUMA J, AOKI M, MORISHITA R, OGIHARA T. Therapeutic Angiogenesis in Peripheral Arterial Disease and Cardiovascular Disease : Introduced by Transfection of Hepatocyte Growth Factor Gene. 血管26(3), 87-94, 2003 Sep 24
  8. Hayashi S, Azuma J, Ogihara T, Morishita R. Nippon Rinsho. Gene therapy for myocardial regeneration. 2003 May;61(5):867-70. Review.
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