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Home ＞ グループ紹介 ＞ 共同研究グループ

グループ紹介

共同研究グループ
  Gリーダー 研究テーマ 主な論文

主な論文

青木元邦 勝谷友宏 里 直行 谷山義明 橋弥尚孝 日比野佐和子
東 純哉 牧野寛史 志水秀郎 家串和真 林 真一郎  
家串和真
Original article（英語）
  1. Boon RA, Iekushi K, Lechner S, Seeger T, Fischer A, Heydt S, Kaluza D, Treguer K, Carmona G, Bonauer A, Horrevoets AJ, Didier N, Girmatsion Z, Biliczki P, Ehrlich JR, Katus HA, Muller OJ, Potente M, Zeiher AM, Hermeking H, Dimmeler S. MicroRNA-34a regulates cardiac aging and function. Nature. 2013 Feb 20. doi: 10.1038/nature11919.
  2. Yokoi T, Azuma J, Nakade Y, Sanada F, Iekushi K, Masamichi Y, Masuda M, Koriyama Y, Taniyama Y, Masaki H, Morishita R, Takahashi T. Comparison between two carcium antagonist: blood pressure reduction and renal effects in hypertensive patients with type 2 diabetes. IEMAMC 2012 in press.
  3. Iekushi K, Seeger F, Assmus B, Zeiher AM, Dimmeler S. Paracrine regulation of cardiac miRNAs by bone marrow mononuclear cell therapy in myocardial infarction. Circ. 2012 in press.
  4. Xu Q, Seeger F, Castillo J, Iekushi K, Boon R, Farcas R, Manavski Y, Li Y, Assmus B, Zeiher AM, Dimmeler S. miR-34a contributes to the impaired function of bone marrow-derived mononuclear cells from patients with cardiovascular disease. JACC 2012 in press.
  5. Okayama K, Azuma J, Dosaka N, Iekushi K, Sanada F, Kusunoki H, Iwabayashi M, Rakugi H, Taniyama Y, Morishita R. Hepatocyte Growth Factor Reduces Cardiac Fibrosis by Inhibiting Endothelial-Mesenchymal Transition. Hypertens. 2012 Mar 5.
  6. Kusunoki H, Taniyama Y, Azuma J, Iekushi K, Sanada F, Otsu R, Iwabayashi M, Okayama K, Rakugi H, Morishita R. Evidence of contribution of perioxisome proliferator activated receptor gamma; activation to organ protective actions of telmisartan independent of angiotensin II type 1 receptor blockade. Hypertens. 2012 Jan 17.
  7. Iwabayashi M, Taniyama Y, Sanada F, Azuma J, Iekushi K, Kusunoki H, Chatterjee A, Okayama K, Rakugi H, Morishita R. Role of serotonin in angiogenesis: Induction of angiogenesis by sarpogrelate via endothelial 5-HT1B/Akt/eNOS pathway in diabetic mice. Atherosclerosis. 2012 Feb; 220(2):337-42.
  8. Assmus B, Iwasaki M, Schächinger V, Roexe T, Koyanagi M, Iekushi K, Xu Q, Tonn T, Seifried E, Liebner S, Kranert WT, Grünwald F, Dimmeler S, Zeiher AM. Acute myocardial infarction activates progenitor cells and increases Wnt signaling in the bone marrow. Eur heart J. 2011 Dec 15.
  9. Iekushi K, Taniyama Y, Kusunoki H, Azuma J, Sanada F, Okayama K, Koibuchi N, Iwabayashi M, Rakugi H, Morishita R. Hepatocyte growth factor attenuates transforming growth factor-β-angiotensin II crosstalk through inhibition of the PTEN/Akt pathway. Hypertens. 2011 Aug;58(2):190-6.
  10. Kyutoku M, Taniyama Y, Katsuragi N, Shimizu H, Kunugiza Y, Iekushi K, Koibuchi N, Sanada F, Oshita Y, Morishita R. Role of periostin in cancer progression and metastasis: Inhibition of breast cancer progression and metastasis by anti-periostin antibody in a murine model. Int J Mol Med. 2011 Aug;28(2):181-6.
  11. Mersmann J, Berkels R, Zacharowski P, Tran N, Koch A, Iekushi K, Dimmeler S, Granja TF, Boehm O, Claycomb WC, Zacharowski K. Preconditioning by toll-like receptor 2 agonist Pam3CSK4 reduces CXCL1-dependent leukocyte recruitment in murine myocardial ischemia/reperfusion injury. Crit Care Med. 2010 Mar; 38(3):903-9.
  12. Iekushi K, Taniyama Y, Azuma J, Sanada F, Kusunoki H, Yokoi T, Koibuchi N, Okayama K, Rakugi H, Morishita R. Hepatocyte growth factor attenuates renal fibrosis through TGF-β1 suppression by apoptosis of myofibroblasts. J Hypertens. 2010 Dec;28(12):2454-61.
  13. Yoon CH, Koyanagi M, Iekushi K, Seeger F, Urbich C, Zeiher AM, Dimmeler S. Mechanism of improved cardiac function after bone marrow mononuclear cell therapy: role of cardiovascular lineage commitment. Circ. 2010 May 11;121(18):2001-11.
  14. Koyanagi M, Iwasaki M, Rupp S, Tedesco FS, Yoon CH, Boeckel JN, Trauth J, Schütz C, Ohtani K, Goetz R, Iekushi K, Bushoven P, Momma S, Mummery C, Passier R, Henschler R, Akintuerk H, Schranz D, Urbich C, Galvez BG, Cossu G, Zeiher AM, Dimmeler S. Sox2 transduction enhances cardiovascular repair capacity of blood-derived mesoangioblasts. Circ Res. 2010 Apr 16;106(7):1290-302.
  15. Sanada F, Taniyama Y, Iekushi K, Azuma J, Okayama K, Kusunoki H, Koibuchi N, Doi T, Aizawa Y, Morishita R. Negative action of hepatocyte growth factor/c-Met system on angiotensin II signaling via ligand-dependent epithelial growth factor receptor degradation mechanism in vascular smooth muscle cells. Circ Res. 2009 Sep 25;105(7):667-75.
  16. Sanada F, Taniyama Y, Azuma J, Iekushi K, Dosaka N, Yokoi T, Koibuchi N, Kusunoki H, Aizawa Y, Morishita R. Hepatocyte growth factor, but not vascular endothelial growth factor, attenuates angiotensin II-induced endothelial progenitor cell senescence. Hypertens. 2009 Jan;53(1):77-82.
  17. Iekushi K, Taniyama Y, Azuma J, Katsuragi N, Dosaka N, Sanada F, Koibuchi N, Nagao K, Ogihara T, Morishita R. Novel mechanisms of valsartan on the treatment of acute myocardial infarction through inhibition of the antiadhesion molecule periostin. Hypertens. 2007 Jun;49(6):1409-14.
  18. Azuma J, Taniyama Y, Takeya Y, Iekushi K, Aoki M, Dosaka N, Matsumoto K, Nakamura T, Ogihara T, Morishita R. Angiogenic and antifibrotic actions of hepatocyte growth factor improve cardiac dysfunction in porcine ischemic cardiomyopa thy. Gene Ther. 2006; 13 (16): 1206-13.
Original article（日本語）
  1. 家串和真、冨田奈留也、伊東範尚、岡石幸也、和田英路、米延策雄、信友政明、楽木宏実、荻原俊男 腎盂腎炎及び腰椎化膿性椎間板炎により敗血症を来した高齢者の一例　化学療法の領域、Vol7、No.5、127-131、2001
Review（英語）
  1. Taniyama Y, Azuma J, Iekushi K, Sanada F, Iwabayashi M, Kusunoki H, Okayama K,Otsu R, Rakugi H, Morishita R; The HGF/c-Met receptor system under pathologicalconditions, IEMAMC 2012 in press
  2. Taniyama Y, Takeya Y, Azuma J, Iekushi K, Sanada F, Kusunoki H, Okayama K, Koibuchi N , Rakugi H and Morishita R; HGF as angiogenic factor and therapeutic approach,Current Signal Transduction Therapy 2011; 2: 221-227(7)
Review（日本語）
  1. Taniyama Y, Morishita R, Azuma J, Iekushi K. Therapeutic angiogenesis for ischemicheart disease induced by gene transfer. Nippon Rinsho. 2005 Dec;63 Suppl 12:588-93.Review.
  2. Taniyama Y, Morishita R, Azuma J, Iekushi K, Ogihara T. Gene therapy for diabetic　 microangiopathy. Nippon Rinsho. 2005 Jun;63 Suppl 6:153-8. Review.
青木元邦 勝谷友宏 里 直行 谷山義明 橋弥尚孝 日比野佐和子
東 純哉 牧野寛史 志水秀郎 家串和真 林 真一郎  
  Gリーダー 研究テーマ 主な論文
[共同研究グループ]
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