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Home ＞ グループ紹介 ＞ 共同研究グループ

グループ紹介

共同研究グループ
  Gリーダー 研究テーマ 主な論文

主な論文

青木元邦 勝谷友宏 里 直行 谷山義明 橋弥尚孝 日比野佐和子
東 純哉 牧野寛史 志水秀郎 家串和真 林 真一郎  
青木元邦
  1. Shiraya S, Miyake T, Aoki M, Yoshikazu F, Ohgi S, Nishimura M, Ogihara T, Morishita R. Inhibition of development of experimental aortic abdominal aneurysm in rat model by atorvastatin through inhibition of macrophage migration. Atherosclerosis 2009; 202 (1) 34-40.
  2. Fujiwara Y, Shiraya S, Miyake T, Yamakawa S, Aoki M, Makino H, Nishimura M, Morishita R. Inhibition of experimental abdominal aortic aneurysm in a rat model by the angiotensin receptor blocker valsartan. International Journal of Molecular Medicine 2008; 22(6) 703-708.
  3. Miyake T, Aoki M, Morishita R. Inhibition of anastomotic intimal hyperplasia using a chimeric decoy strategy against NFkappaB and E2F in a rabbit model. Cardiovascular Research 2008; 79(4)706-714.
  4. Egashira K, Suzuki J, Ito H, Aoki M, Isobe M, Morishita R. Long-term follow up of initial clinical cases with NF-kappaB decoy oligodeoxynucleotide transfection at the site of coronary stenting. Journal of Gene Medicine 2008; 10(7) 805-809.
  5. Nakagawa A, Makino H, Aoki M, Miyake T, Shiraya S, Nakamura T, Ogihara T, Kimata Y, Morishita R. Improvement of survival of skin flaps by combined gene transfer of hepatocyte growth factor and prostacyclin synthase. Journal of Gene Medicine 2007; 9(12) 1087-1094.
  6. Miyake T, Aoki M, Masaki H, Kawasaki T, Oishi M, Kataoka K, Ogihara T, Kaneda Y, Morishita R. Rgression of abdominal aortic aneurysms by simultaneous inhibition of nuclear factor kappaB and ets in a rabbit model. Circulation Research 2007; 101(11) 1175-1184.
  7. Miyake T, Aoki M, Nakashima H, Kawasaki T, Oishi S, Kataoka K, Tanemoto K, Ogihara T, Kaneda Y, Morishita R. Prevention of abdominal aortic aneurysms by simultaneous inhibition of NFkappaB and ets using chimeric decoy oligonucleotides in a rabbit model. Gene Therapy 2006; 13 (8) 695-704.
  8. Shiraya S, Miwa K, Aoki M, Miyake T, Oishi M, Kataoka K, Ohgi S, Ogihara T, Kaneda Y, Morishita R. Hypertension accelerated experimental abdominal aortic aneurysm through upregulation of nuclear factor kappaB and Ets. Hypertension 2006; 48(4) 628-636.
  9. Miyake T, Aoki M, Shiraya S, Tanemoto K, Ogihara T, Kaneda Y, Morishita R. Inhibitory effects of NFkappaB decoy oligodeoxynucleotides on neointimal hyperplasia in a rabbit vein graft model. Journal of Molecular Cellular Cardiology2006; 41(3) 431-440.
  10. Tashiro H, Aoki M, Isobe M, Hashiya N, Makino H, Kaneda Y, Ogihara T, Morishita R. Development of novel method of non-viral efficient gene transfer into neonatal cardiac myocytes. Journal of Molecular Cellular Cardiology 2005; 39(3) 503-509.
  11. Miwa K, Nakashima H, Aoki M, Miyake T, Kawasaki T, Iwai M, Oishi M, Kataoka K, Ohgi S, Ogihara T, Kaneda Y, Morishita R. Inhibition of ets, an essential transcription factor for angiogenesis, to prevent the development of abdominal aortic aneurysm in a rat model. Gene Therapy 2005; 12 (14) 1109-1118.
  12. Morishita R, Aoki M, Hashiya N, Makino H, Yamasaki K, Azuma J, Sawa Y, Matsuda H, Kaneda Y, Ogihara T. Safety evaluation of clinical gene therapy using hepatocyte growth factor to treat peripheral arterial disease by therapeutic angiogenesis. Hypertension 2004; 44 (2) 203-209.
  13. Hashiya N, Jo N, Aoki M, Matsumoto K, Nakamura K, Sato Y, Ogata N, Ogihara T, Kaneda Y, Morishita R. In vivo evidence of angiogenesis induced by transcription factor, ets-1: ets-1 is located upstream of angiogenesis cascade. Circulation 2004;109:3035-3041
  14. Makino H, Aoki M, Hashiya N, Yamasaki K, Hiraoka K, Shimizu H, Azuma J, Kurinami H, Ogihara T, Morishita R. Increase in peripheral blood flow by intravenous administration of prostaglandin E1 in patients with peripheral arterial disease, accompanied by up-regulation of hepatocyte growth factor (HGF). Hypertension Research 2003;27:85-91
  15. Nakashima H, Aoki M, Miyake T, Kawasaki T, Iwai M, Jo N, Oishi M, Kataoka K, Ohigi S, Ogihara T, Kaneda Y, Morishita R. Inhibition of experimental abdominal aortic aneurysm in the rat by use of decoy oligodeoxynucleotides suppressing activity of NFkB and ets transcription factors. Circulation 2004;109:132-138
  16. Namba T, Koike H, Murakami K, Aoki M, Makino H, Hashiya N, Ogihara T, Kaneda Y, Kohno M, Morishita R. Angiogenesis induced by endothelial nitric oxide synthase gene through VEGF expression in rat hindlimb ischemia model. Circulation 2003;108:2250-2257
  17. Koike H, Morishita R, Iguchi S, Aoki M, Matsumoto K, Nakamura T, Yokoyama C, Tanabe T, Ogihara T, Kaneda Y. Enhanced angiogenesis and improvement of neuropathy by co-transfection of human hepatocyte growth factor and prostacyclin synthase gene. The FASEB Journal 2003;17:779-781
  18. Nakamura H, Aoki M, Tamai K, Oishi M, Ogihara T, Kaneda Y, Morishita R. Prevention and regression of atopic dermatitis by ointment containing NF-kB decoy oligodeoxynucleotides in NC/Nga atopic mouse model. Gene Therapy 2002;9:1221-1229
  19. Aoki M, Morishita R, Hayashi SI, Jo N, Matsumoto K, Nakamaura T, Kaneda Y, Ogihara T. Inhibition of neointimal formation after balloon injury by cilostazol, accompanied by improvement of endothelial dysfunction and induction of hepatocyte growth factor in rat diabetes model. Diabetologia 2001;44:1034-1042
  20. Aoki M, Nata T, Morishita R, Matsushita H, Nakagami H, Yamamoto K, Yamazaki K, Nakabayashi M, Ogihara T, Kaneda Y. Endothelial apoptosis induced by oxidative stress through activation of NFkB: anti-apoptotic effect of antioxidant agents on endothelial cells. Hypertension 2001;38:48-55
  21. Matsushita H, Morishita R, Aoki M, Tomita N, Taniyama Y, Nakagami H, Shimozato T, Higaki J, Kaneda Y, Ogihara T. Transfection of antisense p53 tumor suppressor gene oligodeoxynucleotides into rat carotid artery resulted in abnormal growth of vascular smooth muscle cells. Circulation 2000;101:1447-1452
  22. Aoki M, Morishita R, Taniyama Y, Kida I, Moriguchi A, Matsumoto K, Nakamura T, Kaneda Y, Higaki J, Ogihara T. Angiogenesis induced by hepatocyte growth factor in non-infarcted myocardium and infarcted myocardium: up-regulation of essential transcription factor for angiogenesis, ets. Gene Therapy 2000;7:417-427
  23. Higaki J, Aoki M, Morishita R, Kida I, Taniyama Y, Tomita N, Yamamoto K, Moriguchi A, Kaneda Y, Ogihara T. In vivo evidence of importance of cardiac angiotensin converting enzyme in the pathogenesis of cardiac hypertrophy. Arteriosclerosis, Thrombosis & Vascular Biology 2000;20:428-434.
  24. Aoki M, Morishita R, Matsushita H, Hayashi S, Nakagami H, Yamamoto K, Moriguchi A, Kaneda Y, Higaki J, Ogihara T. Inhibition of the p53 tumor suppressor gene resulted in growth of human aortic vascular smooth muscle cells (VSMC): potential role of p53 in regulation of VSMC growth. Hypertension 1999;34:192-200
  25. Morishita R, Sugimoto T, Aoki M, Kida I, Tomita N, Moriguchi A, Maeda K, Sawa Y, Kaneda Y, Higaki J, Ogihara T. In Vivo Transfection of cis element "decoy" against NFkB binding site prevented myocardial infarction as gene therapy. Nature Medicine 1997;3:894-899.
  26. Aoki M, Morishita R, Muraishi A, Moriguchi A, Sugimoto T, Maeda K, Dzau VJ, Kaneda Y, Higaki J, Ogihara T. Efficient in vivo gene transfer into heart in rat myocardial infarction model using HVJ (Hemagglutinating Virus of Japan)-liposome method. Journal of Molecular and Cellular Cardiology 1997;29:949-959.
  27. Aoki M, Morishita R, Higaki J, Moriguchi A, Hayashi S, Matsushita H, Kida I, Tomita N, Sawa Y, Kaneda Y, Ogihara T. Survival of grafts of genetically modified cardiac myocytes transfected with FITC-labeled oligodeoxynucleotides and beta-galactosidase gene in non-infarcted area, but not myocardial infarcted area. Gene Therapy 1997;4:120-127.

その他　60編

青木元邦 勝谷友宏 里 直行 谷山義明 橋弥尚孝 日比野佐和子
東 純哉 牧野寛史 志水秀郎 家串和真 林 真一郎  
  Gリーダー 研究テーマ 主な論文
[共同研究グループ]
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