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Home > Groups > Publications (Specially appointed researchers)

Groups

Specially appointed researchers group
  Leader Publications

Publications

Motokuni
Aoki		 Tomohiro
Katsuya		 Naoyuki
Sato		 Yoshiaki
Taniyama		 Naotaka
Hashiya		 Junya
Azuma
Hirofumi
Makino		 Hideo
Shimizu		 Kazuma
Iekushi		 Shin-ichiro
Hayashi		 Takashi
Miyake		 Katsutoshi
Tamura
Tomohiro Katsuya
  1. Katsuya T, Kario K, Ohishi M, Shimosawa T, Sguisajau K, Furugori T, Taguchi T. Effect of body mass index on the efficacy and safety of esaxerenone versus trichlormethiazide for the treatment of Japanese patients with uncontrolled essential hypertension: a subanalysis of the Excite-HT Study. J Clin Hypertens. 2026; 28: e70314.
  2. Katsuya T, Nakatsu F, Eguchi S, Nakamura Y, Matsukawa M, Iekushi K, Hiramitsu S. Impact of treatment strategies incorporating sacubitril/valsartan on achievement of guideline-recommended blood pressure targets and representative safety outcomes. Hypertens Res, 2026; 49 (4), 1232-44.
  3. Nakagawa-Tsutsui W, Fujioka Y, Tabara Y, Katsuya T, Tsutsui Y, Mamoto R, Ohira H, Asahara S, Kido Y. Practical prediction of 24-hour urinary sodium excretion in young people: a new formula derived from Tanaka and INTERSALT formulas. Hypertens Res. 2026; 49, 2110-22.
  4. Ohishi M, Kario K, Katsuya T,, Shimosawa Y. Shiosakai K, Furugori T, Taguchi T. Efficacy and safety of esaxerenone vs trichlormethiazide for the treatment of uncontrolled essential hypertension in Japanese patients with type 2 diabetes mellitus: a subanalysis of the EXCITE-HT study. Hypertens Res. 2026;49(2):444-456.
  5. Ohya Y, Arakawa K, Arata N, Arima S, Arima H, Asayama K, Dohi Y, Fukami A, Furuhashi M, Goto K, Goto R, Hatta T, Hirawa N, Hirooka Y, Hisamatsu T, Hoshide S, Ikezumi Y, Inoue S, Ishida M, Ishimitsu T, Iwashima Y, Kabayama M, Kabutoya T, Kai H, Kaneko H, Kanno Y, Katsuya T, Kikuchi T, Koga M, Kudo M, Kuwabara M, Matsumura K, Metoki H, Mito A, Miura SI, Miura K, Miyashita K, Mogi M, Kawakami-Mori F, Morimoto S, Mukai M, Mukoyama M, Munakata M, Nakagawa N, Ohkubo T, Okura T, Rakugi H, Shibata S, Shinohara K, Takami T, Takase H, Takemi Y, Tanaka A, Tomiyama H, Toyoda K, Tsuchihashi T, Ueda S, Yamamoto E, Yamamoto K, Sakima A. The Japanese Society of Hypertension Guidelines for the management of elevated blood pressure and hypertension 2025 (JSH2025). Hypertens Res.2026;49(1):9-235.
  6. Takeuchi F, Yamamoto M, Nakatochi M, Takano K, Okazaki A, Emoto S, Tabara Y, Katsuya T, Yamamoto K, Isono M, Mori K, Matsubara T, Ichihara S, Yokota M, Hara H, Hiroi Y, Kato N. Simultaneous assessment of genetic and epigenetic contributions to the plasma lipid levels with respect to cardiovascular risk. J Atheroscler Thromb. 2026 Feb 19. doi: 10.5551/jat.66000.
  7. Kario K, Ohishi M, Katsuya T, Shimosawa T, Shiosakai K, Furugori T, Taguchi T; EXCITE-HT investigators. Effect of N-terminal pro B-type natriuretic peptide levels on the efficacy and safety of esaxerenone vs trichlormethiazide for the treatment of Japanese patients with uncontrolled essential hypertension: a subanalysis of the EXCITE-HT study. Hypertens Res.2026 Feb;49(2):431-443.
  8. Kario K, Tomitani N, Harada N, Morimoto T, Okazaki O, Komi R, Sekizuka H, Nomura K, Yumino D, Katsuya T, Sato T, Uemoto K, Tanigawa T, Hisaki F, Hoshide S. Efficacy Determinants of Hypertension Digital Therapeutics: The B-INDEX Study. Hypertension. 2026 Jan;83(1):157-166.
  9. Kario K, Nishiyama A, Shibata S, Mogi M, Arima H, Kishi T, Ishida M, Furuhashi M, Ichihara A, Katsuya T, Miura K, Miura SI, Node K, Ohishi M, Shibata H, Shimosawa T, Sugawara A, Tamura K, Toyoda K, Yamamoto K; the Promoting Committee for Morning Hypertension Eradication. Declaration for the eradication of morning hypertension. Hypertens Res. 2025 Sep;48(9):2287-2289.
  10. Motoki H, Kuwahara K, Uchida HA, Wada J, Kario K, Katsuya T, Shimosawa T, Tsujita K, Suzuki S, Suedomi T, Taguchi T. Efficacy and safety of esaxerenone with and without sodium-glucose cotransporter-2 inhibitor use in hypertensive patients with type 2 diabetes mellitus: a pooled analysis of five clinical studies. Hypertens Res. 2025 Nov;48(11):2924-2937.
  11. Akasaka H, Tabara Y, Fukuma K, Hiromine Y, Takata Y, Fukuda M, Katsuya T, Ihara M, Osawa H, Ikegami H, Igase M, Rakugi H, Sugimoto K. Association between plasma mid-regional pro-adrenomedullin levels and muscle properties. Geriatr Gerontol Int.2025 Oct;25(10):1418-1424.
  12. Kobayashi K, Chin K, Furuki T, Sakai H, Miyakawa M, Asayama K, Eguchi N, Katsuya T, Sato K, Tamura K, Kanamori A. Cross-sectional Survey of Hypertension Management among Patients Stratified by Chronic Kidney Disease in Japan. JMA J. 2025 Oct 15;8(4):1240-1249.
  13. Aita K, Nishikawa M, Hattori Y, Hirahara S, Hirakawa Y, Katayama Y, Katsuya T, Yanagawa M, Harada K, Koba S, Aida N, Komiya H, Shimizu T, Nakano H, Hasegawa H, Miura H, Momose Y, Tsuji T, Kozaki K. The Japan Geriatrics Society 2025 Position Statement on End-of-Life Care for Older Adults: English Translation of the Japanese Article. Geriatr Gerontol Int. 2025 Oct 15.
  14. Zhang M, Brown MR, Bentley AR, Winkler TW, Noordam R, Nagarajan P, Guo B, Lee S, Schwander K, Wang W, Westerman K, O'Connell JR, Ammous F, Argoty-Pantoja AD, Bartz TM, Batini C, Boua PR, Cordell HJ, Díez-Ahijado L, Dimitrov L, Do AN, Du J, Feitosa MF, Giri A, Giulianini F, Gudmundsdottir V, Guo X, Harris SE, Hasbani NR, Herold JM, Hikino K, Hofer E, Hsu FC, Jackson AU, Kho M, Kraja AT, Lyytikäinen LP, Meirhaeghe A, Muntaner M, Nakatochi M, Nardone GG, Nutile T, Palmer ND, Pecori A, Rao VS, Rauramaa R, Sanghvi MM, Santin A, Shen B, Stringham HM, Takeuchi F, Tan YA, Tang J, Thériault S, Trofimova O, Trompet S, van der Most PJ, Wang YX, Wang Z, Wang Y, Ware EB, Weiss S, Wickremasinghe AR, Yu C, Zhu W, Ansari MAY, Anugu P, Banas B, Barr RG, Basnet TB, Boerwinkle E, Böger CA, Breyer M, Broeckel U, Bryant L, Cade B, Camarda S, Cennamo P, Checkley W, Chee ML, Chen G, Coley K, Collins SD, de Borst MH, de Las Fuentes L, Deary IJ, Dupont CT, Enzinger C, Faquih T, Faul JD, Silva LF, Gauthier V, Gepner AD, Gorski M, Grabe HJ, Graff M, Gu CC, He J, Heikkinen S, Hidalgo B, Highland HM, Hixson JE, Hood MM, Hunt SC, Irvin MR, Isono M, Kähönen M, Kardia SLR, Karvonen-Gutierrez CA, Kasturiratne A, Katsuya T, Kaufman JD, Koistinen HA, Komulainen P, Krämer BK, Launer LJ, Leonard H, Levy D; Lifelines Cohort Study; Liu J, Marques-Vidal P, Martinez-Perez A, Matsuda K, McNeil JJ, Milaneschi Y, Miranda JJ, Morrison JL, Nalls M, Ng MC, Nolte IM, Norris JM, Oravilahti A, Patki A, Petty LE, Peyser PA, Pianigiani G, Raffield LM, Raitakari OT, Ramsay M, Rice KM, Ridker PM, Risch L, Risch M, Ruggiero D, Ruiz-Narvaez EA, Russ TC, Sabanayagam C, Vaitinadin NS, Schmidt R, Scott LJ, Singh S, Sitlani CM, Smit RAJ, Smith JA, Sun Q, Tai ES, Taylor KD, Tesolin P, Tham YC; Biobank Japan Project; Tinashe C, van Dam RM, Vaucher J, Völker U, Wang C, Wilson OD, Wong TY, Xu J, Yamamoto K, Yao J, Yokota M, Young KL, Zimmermann ME, Amouyel P, Below JE, Bergmann S, Bernabe-Ortiz A, Bierut L, Boehnke M, Bowden DW, Brandenburg JT, Chasman DI, Cheng CY, Ciullo M, Concas MP, Conen D, Cox SR, Dauchet L, de Silva HJ, Dörr M, Edwards TL, Fox ER, Franceschini N, Freedman BI, Girotto G, Gudnason V, Harlow SD, Heid IM, Hung AM, Ichihara S, Jaquish CE, John C, Jonas JB, Jukema JW, Kato N, Keavney BD, Kelly TN, Laakso M, Lacaze P, Lakka T, Lee S, Lehtimäki T, Liu CT, Loos RJF, North KE, Penninx B, Province MA, Psaty BM, Redline S, Rosendaal FR, Rotimi CN, Rotter JI, Sabater-Lleal M, Schmidt H, Sim X, Snieder H, Spedicati B, Stark KJ, Terao C, Wagenknecht LE, Weir DR, Zhao W, Zhu X, Munroe PB, Sun YV, Gauderman J, Manning AK, Fornage M, Aschard H, Wang H, de Vries PS, Wang G, Rao DC, Morrison AC, Chen H. Large-Scale Gene-Smoking Interactions and Fine Mapping Study Identifies Multiple Novel Blood Pressure Loci in over 1 Million Individuals. medRxiv [Preprint]. 2025 Oct 7:2025.10.06.25337440. doi: 10.1101/2025.10.06.25337440.
  15. Kario K, Nishiyama A, Shibata S, Mogi M, Arima H, Kishi T, Ishida M, Furuhashi M, Ichihara A, Katsuya T, Miura K, Miura SI, Node K, Ohishi M, Shibata H, Shimosawa T, Sugawara A, Tamura K, Toyoda K, Yamamoto K; the Promoting Committee for Morning Hypertension Eradication. Declaration for the eradication of morning hypertension. Hypertens Res.2025 Sep;48(9):2287-2289.
  16. Smit RAJ, Wade KH, Hui Q, Arias JD, Yin X, Christiansen MR, Yengo L, Preuss MH, Nakabuye M, Rocheleau G, Graham SE, Buchanan VL, Chittoor G, Graff M, Guindo-Martínez M, Lu Y, Marouli E, Sakaue S, Spracklen CN, Vedantam S, Wilson EP, Chen SH, Ferreira T, Ji Y, Karaderi T, Lüll K, Machado M, Malden DE, Medina- Gomez C, Moore A, Rüeger S, Akiyama M, Allison MA, Alvarez M, Andersen MK, Appadurai V, Arbeeva L, Bartell E, Bhaskar S, Bielak LF, Bis JC, Bollepalli S, Bork-Jensen J, Bradfield JP, Bradford Y, Brandl C, Braund PS, Brody JA, Broeckel U, Burgdorf KS, Cade BE, Cai Q, Camarda S, Campbell A, Cañadas-Garre M, Chai JF, Chesi A, Choi SH, Christofidou P, Couture C, Cuellar-Partida G, Danning R, Degenhardt F, Delgado GE, Delitala A, Demirkan A, Deng X, Dietl A, Dimitriou M, Dimitrov L, Dorajoo R, Eichelmann F, Eliasen AU, Engmann JE, Erdos MR, Fairhurst-Hunter Z, Farmaki AE, Faul JD, Fernandez-Lopez JC, Forer L, Frank M, Freitag-Wolf S, Fritsche LG, Fuchsberger C, Galesloot TE, Gao Y, Geller F, Giannakopoulou O, Giulianini F, Gjesing AP, Goel A, Gordon SD, Gorski M, Grove J, Guo X, Gustafsson S, Haessler J, Hansen TF, Havulinna AS, Haworth SJ, Heard- Costa N, Hemerich D, Highland HM, Hindy G, Ho YL, Hofer E, Holliday E, Horn K, Hornsby WE, Hottenga JJ, Huang H, Huang J, Huerta-Chagoya A, Huo S, Hwang MY, Hwu CM, Iha H, Ikeda DD, Isono M, Jackson AU, Jansen IE, Jiang Y, Johansson I, Jonsson A, Jørgensen T, Kalafati IP, Kanai M, Kanoni S, Kårhus LL, Kasturiratne A, Katsuya T, Kawaguchi T, Kember RL, Kentistou KA, Kim D, Kim HN, Kim YJ, Kleber ME, Knol MJ, Kurbasic A, Lauzon M, Le P, Lea R, Lee JY, Lee WJ, Leonard HL, Li H, Li SA, Li X, Li X, Liang J, Lin H, Lin K, Liu J, Liu X, Lo KS, Long J, Lores-Motta L, Luan J, Lyssenko V, Lyytikäinen LP, Mahajan A, Malik MZ, Mamakou V, Mangino M, Manichaikul A, Marten J, Mattheisen M, McDaid AF, Mei Q, Meiselbach H, Melendez TL, Milaneschi Y, Miller JE, Millwood IY, Mishra PP, Mitchell RE, Møllehave LT, Mononen N, Mucha S, Munz M, Mykkänen J, Nakatochi M, Nardone GG, Nelson CP, Nethander M, Nho CW, Nielsen AA, Nolte IM, Nongmaithem SS, Noordam R, Ntalla I, Nutile T, Pandit A, Pauper M, Petersen ERB, Petersen LV, Piluso F, Polašek O, Poveda A, Pyarajan S, Raffield LM, Rakugi H, Ramirez J, Rasheed A, Raven D, Rayner NW, Riveros C, Rohde R, Ruggiero D, Ruotsalainen SE, Ryan KA, Sabater-Lleal M, Santin A, Saxena R, Scholz M, Shen B, Shi J, Shin JH, Sidore C, Sidorenko J, Sim X, Slieker RC, Smith AV, Smith JA, Smyth LJ, Southam L, Steinthorsdottir V, Sun L, Takeuchi F, Taylor KD, Tayo BO, Tcheandjieu C, Terzikhan N, Tesolin P, Teumer A, Theusch E, Thompson DJ, Thorleifsson G, Timmers PRHJ, Trompet S, Turman C, Vaccargiu S, van der Laan SW, van der Most PJ, van Klinken JB, van Setten J, Verma SS, Verweij N, Veturi Y, Wang CA, Wang C, Wang JS, Wang L, Wang YX, Wang Z, Warren HR, Bin Wei W, Wen W, Wheeler WA, Wickremasinghe AR, Wielscher M, Winsvold BS, Wong A, Wuttke M, Xia R, Yamamoto K, Yang J, Yao J, Young H, Yousri NA, Yu L, Zeng L, Zhang W, Zhang X, Zhao JH, Zhao W, Zhou W, Zimmermann ME, Zoledziewska M, 't Hart LM, Adair LS, Adams HHH, Aguilar-Salinas CA, Al-Mulla F, Arnett DK, Asselbergs FW, Åsvold BO, Attia J, Banas B, Bandinelli S, Beilin LJ, Bennett DA, Bergler T, Bharadwaj D, Biino G, Boerwinkle E, Böger CA, Borja JB, Bouchard C, Bowden DW, Brandslund I, Brumpton B, Buring JE, Caulfield MJ, Chambers JC, Chandak GR, Chanock SJ, Chaturvedi N, Ida Chen YD, Chen Z, Cheng CY, Cho YS, Christensen K, Christophersen IE, Ciullo M, Cole JW, Collins FS, Concas MP, Cooper RS, Cruz M, Cucca F, Cutler MJ, Damrauer SM, Dantoft TM, de Borst GJ, de Geus EJC, de Groot LCPGM, De Jager PL, de Kleijn DPV, de Silva HJ, Dedoussis GV, den Hollander AI, Du S, Easton DF, Eckardt KU, Elders PJM, Eliassen AH, Ellinor PT, Elmståhl S, Erdmann J, Evans MK, Fatkin D, Feenstra B, Feitosa MF, Ferrucci L, Florez JC, Ford I, Fornage M, Franke A, Franks PW, Freedman BI, Gieger C, Girotto G, Golightly YM, Gonzalez- Villalpando C, Gordon-Larsen P, Grallert H, Grant SFA, Grarup N, Griffiths L, Gudnason V, Haiman C, Hakonarson H, Hansen T, Hartman CA, Hattersley AT, Hayward C, Heid IM, Heng CK, Hengstenberg C, Herzig KH, Hewitt AW, Hishigaki H, Hougaard DM, Hoyng CB, Huang PL, Huang W, Huang WY, Huffman JE, Hunt SC, Hutri N, Hveem K, Hyppönen E, Iacono WG, Ichihara S, Ikram MA, Isasi CR, Jarvelin MR, Jin ZB, Jöckel KH, Jonas JB, Joshi PK, Jousilahti P, Jukema JW, Kähönen M, Kamatani Y, Kang KD, Kaprio J, Kardia SLR, Karpe F, Kato N, Kavousi M, Kee F, Kessler T, Khera AV, Khor CC, Kiemeney LALM, Kim BJ, Kim EK, Kim HL, Kirchhof P, Kivimaki M, Koh WP, Koistinen HA, Kokkinos A, Kooner JS, Kooperberg C, Kovacs P, Kraaijeveld A, Kraft P, Krauss RM, Kumari M, Kutalik Z, Laakso M, Lange LA, Langenberg C, Launer LJ, Lee H, Lee NR, Lehtimäki T, Lemaitre RN, Li H, Li L, Lieb W, Lin X, Lind L, Linneberg A, Liu CT, Liu J, Loeffler M, London B, Lu F, Lubitz SA, Mackey DA, Magnusson PKE, Manson JE, Marcus GM, Marques Vidal P, Martin NG, März W, Matsuda F, McCarthy MI, McGarrah RW, McGue M, McKnight AJ, Medland SE, Mellström D, Metspalu A, Mitchell BD, Mitchell P, Mook-Kanamori DO, Mori TA, Morris AD, Mucci LA, Munroe PB, Nalls MA, Nazarian S, Nelson AE, Neville MJ, Newton-Cheh C, Nielsen CS, Niinikoski H, Nikus K, Nöthen MM, Ogunniyi A, Ohlsson C, Oldehinkel AJ, Orozco L, Pahkala K, Pajukanta P, Palmer CNA, Parra EJ, Pattaro C, Pedersen O, Pennell CE, Penninx BWJH, Perusse L, Peters A, Peyser PA, Porteous DJ, Posthuma D, Power C, Pramstaller PP, Province MA, Psaty BM, Qi Q, Qu J, Rader DJ, Raitakari OT, Rallidis LS, Rao DC, Redline S, Reilly DF, Reiner AP, Rhee SY, Ridker PM, Rienstra M, Ripatti S, Ritchie MD, Rivadeneira F, Roden DM, Rosendaal FR, Rotter JI, Rudan I, Rutters F, Ryu S, Sabanayagam C, Salako B, Saleheen D, Salomaa V, Samani NJ, Sanghera DK, Sattar N, Schmidt B, Schmidt H, Schmidt R, Schulze MB, Schunkert H, Scott LJ, Scott RJ, Sever P, Sheu WHH, Shoemaker MB, Shu XO, Simonsick EM, Sims M, Singleton AB, Sinner MF, Smith JG, Snieder H, Spector TD, Spedicati B, Stampfer MJ, Stark KJ, Strachan DP, Tabara Y, Tai ES, Tang H, Tardif JC, Thanaraj TA, Tönjes A, Tuomi T, Tuomilehto J, Tusié-Luna MT, van Dam RM, van der Harst P, Van der Velde N, van Duijn CM, van Schoor NM, Vitart V, Vohl MC, Völker U, Vollenweider P, Völzke H, Vrieze S, Wacher-Rodarte NH, Walker M, Wander GS, Wareham NJ, Watanabe RM, Watkins H, Weir DR, Werge TM, Widen E, Willemsen G, Willett WC, Wilson JF, Wilson PWF, Wong TY, Woo JT, Wright AF, Xu H, Yajnik CS, Yang J, Yokota M, Yuan JM, Zeggini E, Zemel BS, Zheng W, Zhu X, Zillikens MC, Zonderman AB, Zwart JA; 23andMe Research Team; DiscovEHR (DiscovEHR and MyCode Community Health Initiative); eMERGE (Electronic Medical Records and Genomics Network); GPC-UGR; PRACTICAL Consortium; Understanding Society Scientific Group; VA Million Veteran Program; Abecasis GR, Assimes TL, Auton A, Boehnke M, Chasman DI, Esko T, Stefansson K, Lettre G, Lindgren CM, Ng MCY, O'Donnell CJ, Thorsteinsdottir U, Visscher PM, Walters RG, Winkler TW, Wood AR, Deloukas P, Frayling TM, Justice AE, Kilpeläinen TO, Locke AE, Mohlke KL, North KE, Okada Y, Willer CJ, Young KL, Fatumo S, McCaffery JM, Timpson NJ, Hirschhorn JN, Sun YV, Berndt SI, Loos RJF. Polygenic prediction of body mass index and obesity through the life course and across ancestries. Nat Med. 2025 Sep;31(9):3151-3168.
  17. Uchida HA, Wada J, Motoki H, Kuwahara K, Kario K, Katsuya T, Shimosawa T, Tsujita K, Suzuki S, Suedomi T, Taguchi T. Efficacy and safety of esaxerenone in hypertensive patients with chronic kidney disease, with or without type 2 diabetes mellitus: a pooled analysis of five clinical studies. Hypertens Res. 2025 Sep;48(9):2413-2426.
  18. Huerta-Chagoya A, Kim J, Mandla R, Lu Y, Suzuki K, Petty LE, Ng HK, Choi J, Lee S, Rout M, Lin K, Adair LS, Adeyemo A, Ahsan H, Akiyama M, An P, Anand SS, Becker DM, Bertoni AG, Bian Z, Bielak LF, Blangero J, Boehnke M, Bottinger EP, Bowden DW, Bragg F, Brody JA, Buchanan TA, Cade BE, Chai JF, Chambers JC, Chandak GR, Chang LC, Chang KM, Chee ML, Chen CH, Chen YT, Chen Z, Chen YI, Chen J, Chen G, Chen SH, Chen WM, Cheng CY, Cho YS, Choi HS, Chuang LM, Cruz M, Cushman M, Das SK, DeFronzo RA, deSilva HJ, Dimitrov L, Doumatey AP, Du S, Duan Q, Duggirala R, Emery LS, Engert JC, Evans DS, Evans MK, Finer S, Florez JC, Floyd JS, Fornage M, Frankel EG, Freedman BI, García-García L, Genter P, Gerstein HC, Goodarzi MO, Gordon-Larsen P, Graff M, Gross M, Guo Y, Guo X, Hai Y, Hanis CL, Hayes M, Horikoshi M, Howard AG, Hsu S, Hsueh W, Huang W, Huang M, Hung YJ, Hwang MY, Hwu CM, Ichihara S, Igase M, Ipp E, Islam MT, Isono M, Jang HM, Jasmine F, Jonas JB, Joo YY, Kabagambe E, Kadowaki T, Kamatani Y, Kandeel FR, Kardia SLR, Karlson EW, Kasturiratne A, Kato N, Katsuya T, Kaur V, Kawaguchi T, Keaton JM, Kho AN, Khor CC, Kibriya M, Kim BJ, Koh WP, Kohara K, Kooner JS, Kooperberg C, Kreienkamp RJ, Lamri A, Lange LA, Lee NR, Lee MS, Lee JJ, Lehman DM, Li L, Li Y, Lim VJ, Liu J, Liu Y, Liu S, Long J, Louie T, Luo X, Lv J, Lynch JA, Maeda S, Mahajan A, Maruthur NM, Matsuda F, McCarthy MI, McKean-Cowdin R, Meigs JB, Millwood IY, Mohlke KL, Motala AA, Nadkarni GN, Nadler JL, Nakatochi M, Nalls MA, Nayak U, Nicolas A, North KE, Nousome D, Okada Y, Pan I, Pankow JS, Paré G, Park J, Park KS, Parra EJ, Patel SR, Pereira MA, Peyser PA, Pirie FJ, Preuss M, Province MA, Psaty BM, Raffel LJ, Raffield LM, Rasmussen-Torvik LJ, Redline S, Reiner AP, Rich SS, Rohde R, Roll K, Roshani R, Rotimi CN, Sabanayagam C, Saleheen D, Sandow K, Schurmann C, Shahriar M, Shaw DM, Sheu WH, Shi J, Shu XO, Shuey MM, Siddiqui MK, Smith JA, Sofer T, Spracklen CN, Stilp AM, Sun M, Tabara Y, Tai ES, Tajuddin SM, Takahashi A, Takeuchi F, Tan J, Taylor KD, Taylor K, Thameem F, Tong L, Tsai FJ, Tsao PS, Udler MS, Valladares-Salgado A, van Heel DA, vanDam RM, Varma R, Vora M, Wacher-Rodarte N, Wang YX, Wheeler E, Whitsel EA, Wickremasinghe AR, Wojcik GL, Wong TY, Wu JY, Xiang YB, Xiang AH, Yajnik CS, Yamamoto K, Yamauchi T, Yanek LR, Yao J, Yokota M, Yu C, Yuan JM, Yusuf S, Zeggini E, Zhang L, Zhang W, Zheng W, Zonderman AB; ENSA Genomics Consortium; Genes & Health Research Team; VA Million Veteran Program; Aguilar- Salinas CA, González-Villalpando C, Haiman CA, Kim YJ, Kwak SH, Leong A, Loos RJF, Moreno-Estrada A, Morris AP, Orozco L, Rotter JI, Sanghera D, Tusie-Luna T, Voight BF, Vujkovic M, Walters RG, Ge T, Manning AK, Loh M, Below JE, Sim X, Mercader JM, Ng MCY. Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries. medRxiv[Preprint]. 2025 Jul 23:2025.07.21.25331778.
  19. Kario K, Ohbayashi H, Hashimoto M, Itabashi N, Kato M, Uchiyama K, Hirano K, Nakamura N, Miyamoto T, Nagashima H, Ishida H, Ebe Y, Hatta T, Fukui T, Katsuya T, Shimosawa T, Taguchi T, Tanabe A, Ohishi M; EXCITE-HT investigators. Home blood pressure-lowering effect of esaxerenone vs trichlormethiazide for uncontrolled hypertension: a prespecified subanalysis of the EXCITE-HT randomized controlled study by age subgroup. Hypertens Res. 2025 Apr;48(4):1586-1598.
  20. Katsuya T, Hisaki F, Aga M, Hirayama Y, Takagi Y, Ichikihara Y, Tanigawa T. Digital therapeutic for hypertension improves physician-patient communication and clinical inertia: a survey of physicians who implemented CureApp HT in clinical practice. Hypertens Res. 2025 Feb;48(2):470-477.
  21. Morita H, Abe M, Suematsu Y, Uehara Y, Koyoshi R, Fujimi K, Ideishi A, Takata K, Kato Y, Hirata T, Yahiro E, Morito N, Kitajima K, Satoh A, Yoshimura C, Ishida S, Okutsu S, Takahashi K, Shinohara Y, Sakaguchi T, Katsuki S, Tada K, Fujii T, Funakoshi S, Hu Y, Satoh T, Ohnishi H, Okamura K, Mizuno H, Arakawa K, Asayama K, Ohtsubo T, Ishigami T, Shibata S, Fujita T, Munakata M, Ohishi M, Ichihara A, Katsuya T, Mukoyama M, Rakugi H, Node K, Arima H, Miura SI. Resistance exercise has an antihypertensive effect comparable to that of aerobic exercise in hypertensive patients: a meta-analysis of randomized controlled trials. Hypertens Res.2025 Feb;48(2):733-743.
  22. Suematsu Y, Morita H, Abe M, Uehara Y, Koyoshi R, Fujimi K, Ideishi A, Takata K, Kato Y, Hirata T, Yahiro E, Morito N, Kitajima K, Yano Y, Satoh A, Yoshimura C, Ishida S, Okutsu S, Takahashi K, Shinohara Y, Sakaguchi T, Katsuki S, Tada K, Fujii T, Funakoshi S, Hu Y, Satoh T, Ohnishi H, Okamura K, Mizuno H, Arakawa K, Asayama K, Ohtsubo T, Ishigami T, Shibata S, Fujita T, Munakata M, Ohishi M, Ichihara A, Katsuya T, Mukoyama M, Rakugi H, Node K, Arima H, Miura SI. Differences in the effects of exercise on blood pressure depending on the physical condition of the subject and the type of exercise: a systematic review and meta-analysis. Hypertens Res.2025 Feb;48(2):720-732.
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  108. Takeuchi F, Isono M, Nabika T, Katsuya T, Sugiyama T, Yamaguchi S, Kobayashi S, Ogihara T, Yamori Y, Fujioka A, Kato N. Confirmation of ALDH2 as a Major locus of drinking behavior and of its variants regulating multiple metabolic phenotypes in a Japanese population. Circ J. 2011;75:911-918.
  109. Sugimoto K, Katsuya T, Kamide K, Fujisawa T, Shimaoka I, Ohishi M, Morishita R, Ogihara T, Rakugi H. Promoter Polymorphism of RGS2 Gene Is Associated with Change of Blood Pressure in Subjects with Antihypertensive Treatment: The Azelnidipine and Temocapril in Hypertensive Patients with Type 2 Diabetes Study. Int J Hypertens, 2010:196307.
  110. Tabara Y, Kohara K, Kita Y, Hirawa N, Katsuya T, Ohkubo T, Hiura Y, Tajima A, Morisaki T, Miyata T, Nakayama T, Takashima N, Nakura J, Kawamoto R, Takahashi N, Hata A, Soma M, Imai Y, Kokubo Y, Okamura T, Tomoike H, Iwai N, Ogihara T, Inoue I, Tokunaga K, Johnson T, Caulfield M, Munroe P, Umemura S, Ueshima H, Miki T. Common Variants in the ATP2B1 Gene Are Associated With Susceptibility to Hypertension. The Japanese Millennium Genome Project. Hypertension, 2010;56:973-80.
  111. Koriyama H, Nakagami H, Katsuya T, Sugimoto K, Yamashita H, Takami Y, Maeda S, Kubo M, Takahashi A, Nakamura Y, Ogihara T, Rakugi H, Kaneda Y, Morishita R. Identification of Evidence Suggestive of an Association with Peripheral Arterial Disease at the OSBPL10 Locus by Genome-Wide Investigation in the Japanese Population. J Atheroscler Thromb. 2010;17:1054-62.
  112. Katsuya T, Morishita R. The challenge of stopping the knocking down of metabolic dominos upstream. Hypertens Res. 2010;33:529-530.
  113. Takeuchi F, Isono M, Katsuya T, Yamamoto K, Yokota M, Sugiyama T, Nabika T, Fujioka A, Ohnaka K, Asano H, Yamori Y, Yamaguchi S, Kobayashi S, Takayanagi R, Ogihara T, Kato N. Blood pressure and hypertension are associated with 7 loci in the Japanese population. Circulation 2010;121:2302-2309.
  114. Oguro R, Kamide K, Kokubo Y, Shimaoka I, Congrains A, Horio T, Hanada H, Ohishi M, Katsuya T, Okamura T, Miyata T, Kawano Y, Rakugi H. Association of carotid atherosclerosis with genetic polymorphisms of the klotho gene in patients with hypertension. Geriatr Gerontol Int. 2010;10:311-8.
  115. Michishita T, Kobayashi S, Katsuya T, Ogihara T, Kawabuchi K. Evaluation of the antiobesity effects of an amino acid mixture and conjugated linoleic acid on conjugated overweight humans: a randomized, double-blind, placebo-controlled trial. J Int. Med. Res. 2010;38:844-859.
  116. Koriyama H, Nakagami H, Katsuya T, Akasaka H, Saitoh S, Shimamoto K, Ogihara T, Kaneda Y, Morishita R, Rakugi H. Variation in OSBPL10 is associated with dyslipidemia. Hypertens Res. 2010;33:511-514.
  117. Shimaoka I, Kamide K, Ohishi M, Katsuya T, Akasaka H, Saitoh S, Sugimoto K, Oguro R, Congrains A, Fujisawa T, Shimamoto K, Ogihara T, Rakugi H. Association of gene polymorphism of the fat-mass and obesity-associated gene with insulin resistance in Japanese. Hypertens Res. 2010;33:214-218.
  118. Takeuchi F, Katsuya T, Chakrewarthy S, Yamamoto K, Fujioka A, Serizawa M, Fujisawa T, Nakashima E, Ohnaka K, Ikegami H, Sugiyama T, Nabika T, Kasturiratne A, Yamaguchi S, Kono S, Takayanagi R, Yamori Y, Kobayashi S, Ogihara T, de Silva A, Wickremasinghe R, Kato N. Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations. Diabetologia. 2010;53:299-308.
  119. Watanabe Y, Metoki H, Ohkubo T, Katsuya T, Tabara Y, Kikuya M, Hirose T, Sugimoto K, Asayama K, Inoue R, Hara A, Obara T, Nakura J, Kohara K, Totsune K, Ogihara T, Rakugi H, Miki T, Imai Y. Accumulation of common polymorphisms is associated with development of hypertension: a 12-year follow-up from the Ohasama study. Hypertens Res.2010;33:129-134.
  120. Takeuchi F, Nabika T, Isono M, Katsuya T, Sugiyama T, Yamaguchi S, Kobayashi S, Yamori Y, Ogihara T, Kato N. Evaluation of genetic loci influencing adult height in the Japanese population. J Hum Genet. 2009;54:749-752.
  121. Akasaka H, Katsuya T, Saitoh S, Sugimoto K, Ohnishi H, Congrains A, Ohnishi M, Ohishi M, Rakugi H, Ogihara T, Shimamoto K. A Promoter Polymorphism of Lamin A/C Gene is an Independent Genetic Predisposition to Arterial Stiffness in a Japanese General Population (The Tanno and Sobetsu Study). J Atheroscler Thromb. 2009;16:404-409.
  122. Miyanaga K, Fukuo K, Akasaka H, Katsuya T, Fukada R, Rakugi H, Kazumi T. C allele of angiotensin II type 1 receptor gene A1166C polymorphism affects plasma adiponectin concentrations in healthy young Japanese women. Hypertens Res. 2009;32:901-905.
  123. Tomiyama-Hanayama M, Rakugi H, Kohara M, Mima T, Adachi Y, Ohishi M, Katsuya T, Hoshida Y, Aozasa K, Ogihara T, Nishimoto N. Effect of Interleukin-6 Receptor Blockage on Renal Injury in Apolipoprotein E-Deficient Mice. Am J Physiol Renal Physiol.2009;297:F679-684.
  124. Katsuya T, Morishita R, Rakugi H, Ogihrara T. Genetic basis of hypertension for the development of tailored medicine. Hypertens Res.2009;32:643-648.
  125. Hanasaki H, Takemura Y, Fukuo K, Ohishi M, Onishi M, Yasuda O, Katsuya T, Awata N, Kato N, Ogihara T, Rakugi H. Fas promoter region gene polymorphism is associated with an increased risk for myocardial infarction. Hypertens Res.2009;32:261-264.
  126. Ueno T, Tabara Y, Fukuda N, Tahira K, Matsumoto T, Kosuge K, Haketa A, Matsumoto K, Sato Y, Nakayama T, Katsuya T, Ogihara T, Makita Y, Hata A, Yamada M, Takahashi N, Hirawa N, Umemura S, Miki T, Soma M. Association of SLC6A9 gene variants with human essential hypertension. J Atheroscler Thromb. 2009;16:201-206.
  127. Takeuchi F, Serizawa M, Yamamoto K, Fujisawa T, Nakashima E, Ohnaka K, Ikegami H, Sugiyama T, Katsuya T, Miyagishi M, Nakashima N, Nawata H, Nakamura J, Kono S, Takayanagi R, Kato N. Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. Diabetes. 2009;58:1690-1699.
  128. Maekawa Y, Ishikawa K, Yasuda O, Oguro R, Hanasaki H, Kida I, Takemura Y, Ohishi M, Katsuya T, Rakugi H. Klotho suppresses TNF-alpha-induced expression of adhesion molecules in the endothelium and attenuates NF-kappaB activation. Endocrine. 2009;35:341-346.
  129. Tatara Y, Ohishi M, Yamamoto K, Shiota A, Hayashi N, Iwamoto Y, Takeda M, Takagi T, Katsuya T, Ogihara T, Rakugi H. Macrophage inflammatory protein-1beta induced cell adhesion with increased intracellular reactive oxygen species. J Mol Cell Cardiol. 2009;47:104-111.
  130. Tsuchihashi-Makaya M, Serizawa M, Yanai K, Katsuya T, Takeuchi F, Fujioka A, Yamori Y, Ogihara T, Kato N. Gene-environmental interaction regarding alcohol-metabolizing enzymes in the Japanese general population. Hypertens Res. 2009;32:207-213.
  131. Hirose T, Hashimoto M, Totsune K, Metoki H, Asayama K, Kikuya M, Sugimoto K, Katsuya T, Ohkubo T, Hashimoto J, Rakugi H, Takahashi K, Imai Y. Association of (pro)renin receptor gene polymorphism with blood pressure in Japanese men: the Ohasama study. Am J Hypertens. 2009;22:294-299.
  132. Sugimoto K, Akasaka H, Katsuya T, Node K, Fujisawa T, Shimaoka I, Yasuda O, Ohishi M, Ogihara T, Shimamoto K, Rakugi H. A Polymorphism Regulates CYP4A11 transcriptional activity and is associated with hypertension in a Japanese population. Hypertension. 2008;52:1142-8.
  133. Katsuya T, Ogihara T. Hypertension and risk stratification. Hypertens Res 2008;31:1271-3.
  134. Masuo K, Straznicky NE, Lambert GW, Katsuya T, Sugimoto K, Rakugi H, Socratous F, Hastings J, Lambert EA, Ogihara T, Esler MD. Leptin-receptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic nerve activation in a Caucasian male population. Hypertens Res 2008;31:1093-1100.
  135. Takami Y, Nakagami H, Morishita R, Katsuya T, Hayashi H, Mori M, Koriyama H, Baba Y, Yasuda O, Rakugi H, Ogihara T, Kaneda Y. Potential Role of CYLD (Cylindromatosis) as a Deubiquitinating Enzyme in Vascular Cells. Am J Pathol. 2008;172:818-29.
  136. Sun X, Yasuda O, Takemura Y, Kawamoto H, Higuchi M, Baba Y, Katsuya T, Fukuo K, Ogihara T, Rakugi H. Akt activation prevents Apop-1-induced death of cells. Biochem Biophys Res Commun. 2008;377:1097-101.
  137. Kohara K, Tabara Y, Nakura J, Imai Y, Ohkubo T, Hata A, Soma M, Nakayama T, Umemura S, Hirawa N, Ueshima H, Kita Y, Ogihara T, Katsuya T, Takahashi N, Tokunaga K, Miki T. Identification of hypertension-susceptibility genes and pathways by a systemic multiple candidate gene approach: the millennium genome project for hypertension. Hypertens Res. 2008;31:203-12.
  138. Ueno T, Soma M, Tabara Y, Tokunaga K, Tahira K, Fukuda N, Matsumoto K, Nakayama T, Katsuya T, Ogihara T, Makita Y, Hata A, Yamada M, Takahashi N, Hirawa N, Umemura S, Miki T. Association between Fatty Acid binding protein 3 gene variants and essential hypertension in humans. Am J Hypertens.2008;21:691-695.
  139. Mashimo Y, Suzuki Y, Hatori K, Tabara Y, Miki T, Tokunaga K, Katsuya T, Ogihara T, Yamada M, Takahashi N, Makita Y, Nakayama T, Soma M, Hirawa N, Umemura S, Ohkubo T, Imai Y, Hata A. Association of TNFRSF4 gene polymorphisms with essential hypertension. J Hypertens.2008;26:902-13.
  140. Kato N, Miyata T, Tabara Y, Katsuya T, Yanai K, Hanada H, Kamide K, Nakura J, Kohara K, Takeuchi F, Mano H, Yasunami M, Kimura A, Kita Y, Ueshima H, Nakayama T, Soma M, Hata A, Fujioka A, Kawano Y, Nakao K, Sekine A, Yoshida T, Nakamura Y, Saruta T, Ogihara T, Sugano S, Miki T, Tomoike H. High-density association study and nomination of susceptibility genes for hypertension in the Japanese National Project. Hum Mol Genet.2008;17:617-27
  141. Nakagami H, Kikuchi Y, Katsuya T, Morishita R, Akasaka H, Saitoh S, Rakugi H, Kaneda Y, Shimamoto K, Ogihara T. Gene polymorphism of myospryn (cardiomyopathy-associated 5) is associated with left ventricular wall thickness in patients with hypertension. Hypertens Res.2007;30:1239-46.
  142. Ohishi M, Takagi T, Ito N, Tatara Y, Hayashi N, Shiota A, Iwamoto Y, Katsuya T, Rakugi H, Ogihara T. Renal protective effect in hypertensive patients -high doses of angiotensin II receptor blocker (HARB) study-. Hypertens Res2007;30:1187-92.
  143. Ohishi M, Takagi T, Ito N, Terai M, Tatara Y, Hayashi N, Shiota A, Katsuya T, Rakugi H, Ogihara T. Renal-protective effect of T-and L-type calcium channel blockers in hypertensive patients: an Amlodipine-to-Benidipine Changeover (ABC) study. Hypertens Res. 2007;30:797-806.
  144. Nakano N, Hori H, Abe M, Shibata H, Arimura T, Sasaoka T, Sawabe M, Chida K, Arai T, Nakahara KI, Kubo T, Sugimoto K, Katsuya T, Ogihara T, Doi Y, Izumi T, Kimura A. Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 2007;293:H3396-403.
  145. Ch'ng ES, Hoshida Y, Iizuka N, Morii E, Ikeda JI, Yamamoto A, Tomita Y, Hanasaki H, Katsuya T, Maeda K, Ohishi M, Rakugi H, Ogihara T, Aozasa K. Composite malignant pheochromocytoma with malignant peripheral nerve sheath tumour: a case with 28 years of tumour-bearing history. Histopathology. 2007;51:420-2.
  146. Masuo K, Katsuya T, Sugimoto K, Kawaguchi H, Rakugi H, Ogihara T, Tuck ML. High plasma norepinephrine levels associated with beta2-adrenoceptor polymorphisms predict future renal damage in nonobese normotensive individuals. Hypertens Res.2007;30:503-11.
  147. Takami Y, Nakagami H, Morishita R, Katsuya T, Cui TX, Ichikawa T, Saito Y, Hayashi H, Kikuchi Y, Nishikawa T, Baba Y, Yasuda O, Rakugi H, Ogihara T, Kaneda Y. Ubiquitin carboxyl-terminal hydrolase L1, a novel deubiquitinating enzyme in the vasculature, attenuates NF-kappaB activation. Arterioscler Thromb Vasc Biol. 2007;27:2184-90.
  148. Katsuya T, Rakugi H, Ogihara T. Inflammation and salt sensitivity in the early state of hypertension. Hypertens Res 2007;30:105-7.
  149. Akasaka H, Katsuya T, Saitoh S, Sugimoto K, Fu Y, Takagi T, Ohnishi H, Rakugi H, Ura N, Shimamoto K, Ogihara T. Effects of angiotensin II type 1 receptor gene polymorphisms on insulin resistance in Japanese general population: the Tannno-Sobetsu Study. Hypertens Res 2006;29:961-7.
  150. Kawaguchi H, Masuo K, Katsuya T, Sugimoto K, Rakugi H, Ogihara T, Tuck ML. β2-and β3-Adrenoceptor polymorphisms relate to subsequent weight gain and blood pressure elevation in obese normotensive individuals. Hypertens Res 2006;29:951-9.
  151. Yuan M, Ohishi M, Ito N, Sugimoto K, Takagi T, Terai M, Katsuya T, Rakugi H, Wu Z, Ogihara T. Genetic influences of β-adrenoceptor polymorphisms on arterial functional changes and cardiac remodeling in hypertensive patients. Hypertens Res 2006;29:875-81
  152. Masuo K, Katsuya T, Kawaguchi H, Fu Y, Rakugi H, Ogihara T, Tuck ML. Beta2-adrenoceptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic activation. Am J Hypertens. 2006;19:1084-91.
  153. Nakayama T, Kuroi N, Sano M, Tabara Y, Katsuya T, Ogihara T, Makita Y, Hata A, Yamada M, Takahashi N, Hirawa N, Umemura S, Miki T, Soma M. Mutation of the follicle-stimulating hormone receptor gene 5'-untranslated region associated with female hypertension. Hypertension. 2006;48:512-8.
  154. Yamamoto K, Ohishi M, Katsuya T, Ito N, Ikushima M, Kaibe M, Tatara Y, Shiota A, Sugano S, Takeda S, Rakugi H, Ogihara T. Deletion of angiotensin-converting enzyme 2 accelerates pressure overload-induced cardiac dysfunction by increasing local angiotensin II. Hypertension. 2006;47:718-26.
  155. Xu R, Ishikawa K, Katsuya T, Fu Y, Akasaka H, Ikushima M, Chihara Y, Ura N, Shimamoto K, Rakugi H, Ogihara T. Association between senescence-related uncoupling protein 2 gene polymorphisms and abdominal obesity in Japanese subjects: the Tanno and Sobetsu Study. Geriatr Gerontol Int. 2006;6:15-9.
  156. Masuo K, Katsuya T, Kawaguchi H, Fu Y, Rakugi H, Ogihara T, Tuck ML. Rebound weight gain as associated with high plasma norepinephrine levels that are mediated through polymorphisms in the beta2-adrenoceptor. Am J Hypertens. 2005;18:1508-1516
  157. Masuo K, Katsuya T, Fu Y, et al. ?2- and ?3-adrenergic receptor polymorphisms are related to the onset of weight gain and blood pressure elevation over 5 Years. Circulation. 2005;111:3429-4.
  158. Masuo K, Katsuya T, Fu Y, Rakugi H, Ogihara T, Tuck ML. Beta2-adrenoceptor polymorphisms relate to insulin resistance and sympathetic overactivity as early markers of metabolic disease in nonobese, normotensive individuals. Am J Hypertens. 2005;18:1009-1014.
  159. Iwashima Y, Katsuya T, Ishikawa K, et al. Association of hypoadiponectinemia with smoking habit in men. Hypertension. 2005;45:1094-1100.
  160. Masuo K, Katsuya T, Fu Y, et al. Lys418Asn polymorphism of the ?2-adrenoceptor gene relates to serum uric acid levels but not to insulin sensitivity. Hypertension 2005;46:144-150.
  161. Masuo K, Katsuya T, Ogihara T, Tuck ML. Acute hyperinsulinemia reduces plasma leptin levels in insulin-sensitive Japanese men. Am J Hypertens. 2005;18:235-43..
  162. Fu Y, Katsuya T, Matsuo A, Yamamoto K, Akasaka H, Takami Y, Iwashima Y, Sugimoto K, Ishikawa K, Ohishi M, Rakugi H, Ogihara T. Relationship of bradykinin B2 receptor gene polymorphism with essential hypertension and left ventricular hypertrophy. Hypertens Res. 2004:27:933-8
  163. Matsuo A, Katsuya T, Ishikawa K, Sugimoto K, Iwashima Y, Yamamoto K, Ohishi M, Rakugi H, Ogihara T. G2736A polymorphism of thiazide-sensitive Na-Cl cotransporter gene predisposes to hypertension in young women. J Hypertens. 2004;22:2123-7.
  164. Sugimoto K, Katsuya T, Ohkubo T, Hozawa A, Yamamoto K, Matsuo A, Rakugi H, Tsuji I, Imai Y, Ogihara T. Association between angiotensin II type 1 receptor gene polymorphism and essential hypertension: the Ohasama Study. Hypertens Res. 2004;27:551-6.
  165. Iwashima Y, Katsuya T, Ishikawa K, Ouchi N, Ohishi M, Sugimoto K, Fu Y, Motone M, Yamamoto K, Matsuo A, Ohashi K, Kihara S, Funahashi T, Rakugi H, Matsuzawa Y, Ogihara T. Hypoadiponectinemia is an independent risk factor for hypertension. Hypertension. 2004;43:1318-23.
  166. Motone M, Katsuya T, Ishikawa K, Iwashima Y, Sugimoto K, Yamamoto K, Fu Y, Matsuo A, Ohishi M, Rakugi H, Ogihara T. Association between hepatocyte growth factor gene polymorphism and essential hypertension. Hypertens Res. 2004;27:247-51.
  167. Fukuchi K, Katsuya T, Sugimoto K, Kuremura M, Kim HD, Li L, Ogihara T. LMNA mutation in a 45 year old Japanese subject with Hutchinson-Gilford progeria syndrome. J Med Genet. 2004;41:e67.
  168. Ji Q, Ikegami H, Fujisawa T, Kawabata Y, Ono M, Nishino M, Ohishi M, Katsuya T, Rakugi H, Ogihara T. A common polymorphism of uncoupling protein 2 gene is associated with hypertension. J Hypertens. 2004;22:97-102.
  169. Ogihara T, Katsuya T, Ishikawa K, Matsuo A, Rakugi H, Shoji M, Yasujima M. Hypertension in a patient with Gitelman's syndrome. J Hum Hypertens. 2004;8:677-9.
  170. Ohashi K, Ouchi N, Kihara S, Funahashi T, Nakamura T, Sumitsuji S, Kawamoto T, Matsumoto S, Nagaretani H, Kumada M, Okamoto Y, Nishizawa H, Kishida K, Maeda N, Hiraoka H, Iwashima Y, Ishikawa K, Ohishi M, Katsuya T, Rakugi H, Ogihara T, Matsuzawa Y. Adiponectin I164T mutation is associated with the metabolic syndrome and coronary artery disease. J Am Coll Cardiol. 2004;43:1195-200.
  171. Takiuchi S, Mannami T, Miyata T, Kamide K, Tanaka C, Kokubo Y, Koyama Y, Inamoto N, Katsuya T, Iwai N, Kawano Y, Ogihara T, Tomoike H. Identification of 21 single nucleotide polymorphisms in human hepatocyte growth factor gene and association with blood pressure and carotid atherosclerosis in the Japanese population. Atherosclerosis. 2004;173:301-7.
  172. Katsuya T, Sugimoto K, Hozawa A, Ohkubo T, Yamamoto K, Matsuo A, Ishikawa K, Matsubara M, Rakugi H, Tsuji I, Imai Y, Ogihara T. Genetic risk factors for cerebral infarction using data from a large scale genetic epidemiological study: the Ohasama Study. Geriat Gerontol Int. 2003;3:150-3.
  173. Katsuya T, Ogihara T. Future medicine in the post-genome age -Targeting tailoed medicine for hypertension-. JMAJ. 2003;46:327-32.
  174. Katsuya T, Ishikawa K, Sugimoto K, Rakugi H, Ogihara T. Salt sensitivity of Japanese from the viewpoint of gene polymorphism. Hypertens Res. 2003;26:521-5.
  175. Inamoto N, Katsuya T, Kokubo Y, Mannami T, Asai T, Baba S, Ogata J, Tomoike H, Ogihara T. Association of methylenetetrahydrofolate reductase gene polymorphism with carotid atherosclerosis depending on smoking status in a Japanese general population. Stroke. 2003;34:1628-33.
  176. Matsubara M, Metoki H, Katsuya T, Kikuya M, Suzuki M, Michimata M, Araki T, Hozawa A, Tsuji I, Ogihara T, Imai Y. T+31C polymorphism (M235T) of the angiotensinogen gene and home blood pressure in the Japanese general population: the Ohasama Study. Hypertens Res. 2003;26:47-52.
  177. Kikuya M, Sugimoto K, Katsuya T, Suzuki M, Sato T, Funahashi J, Katoh R, Kazama I, Michimata M, Araki T, Hozawa A, Tsuji I, Ogihara T, Yanagisawa T, Imai Y, Matsubara M. A/C1166 gene polymorphism of the angiotensin II type 1 receptor (AT1) and ambulatory blood pressure: the Ohasama Study. Hypertens Res. 2003;26:141-5.
  178. Sugimoto K, Hozawa A, Katsuya T, Matsubara M, Ohkubo T, Tsuji I, Motone M, Higaki J, Hisamachi S, Imai Y, Ogihara T. alpha-Adducin Gly460Trp polymorphism is associated with low renin hypertension in younger subjects in the Ohasama study. J Hypertens. 2002;20:1779-84.
  179. Shintani M, Ikegami H, Fujisawa T, Kawaguchi Y, Ohishi M, Katsuya T, Higaki J, Shimamoto K, Ogihara T. Leptin gene polymorphism is associated with hypertension independent of obesity. J Clin Endocrinol Metab. 2002;87:2909-12.
  180. Okuda T, Sumiya T, Mizutani K, Tago N, Miyata T, Tanabe T, Kato H, Katsuya T, Higaki J, Ogihara T, Tsujita Y, Iwai N, Muzutani K. Analyses of differential gene expression in genetic hypertensive rats by microarray. Hypertens Res. 2002;25:249-55.
  181. Morimoto S, Okaishi K, Onishi M, Katsuya T, Yang J, Okuro M, Sakurai S, Onishi T, Ogihara T. Deletion allele of the angiotensin-converting enzyme gene as a risk factor for pneumonia in elderly patients. Am J Med. 2002;112:89-94.
  182. Mizutani K, Sugimoto K, Okuda T, Katsuya T, Miyata T, Tanabe T, Higaki J, Ogihara T, Yamori Y, Tsujita Y, Tago N, Iwai N. Kynureninase is a novel candidate gene for hypertension in spontaneously hypertensive rats. Hypertens Res. 2002;25:135-40.
  183. Matsubara M, Suzuki M, Fujiwara T, Kikuya M, Metoki H, Michimata M, Araki T, Kazama I, Satoh T, Hashimoto J, Hozawa A, Ohkubo T, Tsuji I, Katsuya T, Higaki J, Ogihara T, Satoh H, Imai Y. Angiotensin-converting enzyme I/D polymorphism and hypertension: the Ohasama study. J Hypertens. 2002;20:1121-6.
  184. Komai N, Ohishi M, Moriguchi A, Yanagitani Y, Jinno T, Matsumoto K, Katsuya T, Rakugi H, Higaki J, Ogihara T. Low-dose doxazosin improved aortic stiffness and endothelial dysfunction as measured by noninvasive evaluation. Hypertens Res. 2002;25:5-10.
  185. Katsuya T, Baba S, Ishikawa K, Mannami T, Fu Y, Inamoto N, Asai T, Fukuda M, Higaki J, Ogata J, Ogihara T. Epsilon 4 allele of apolipoprotein E gene associates with lower blood pressure in young Japanese subjects: the Suita Study. J Hypertens. 2002;20:2017-21.
  186. Iwai N, Katsuya T, Mannami T, Higaki J, Ogihara T, Kokame K, Ogata J, Baba S. Association between SAH, an acyl-CoA synthetase gene, and hypertriglyceridemia, obesity, and hypertension. Circulation. 2002;105:41-7.
  187. Fukuda M, Ohkubo T, Katsuya T, Hozawa A, Asai T, Matsubara M, Kitaoka H, Tsuji I, Araki T, Satoh H, Higaki J, Hisamichi S, Imai Y, Ogihara T. Association of a mast cell chymase gene variant with HDL cholesterol, but not with blood pressure in the Ohasama study. Hypertens Res. 2002;25:179-84.
  188. Fujiwara T, Katsuya T, Matsubara M, Mikami T, Ishikawa K, Kikuya M, Ohkubo T, Hozawa A, Michimata M, Suzuki M, Metoki H, Asayama K, Araki T, Tsuji I, Higaki J, Satoh H, Hisamichi S, Ogihara T, Imai Y. T+31C polymorphism of angiotensinogen gene and nocturnal blood pressure decline: the Ohasama study. Am J Hypertens. 2002;15:628-32.
  189. Tsujita Y, Iwai N, Katsuya T, Higaki J, Ogihara T, Tamaki S, Kinoshita M, Mannami T, Ogata J, Baba S. Lack of association between genetic polymorphism of CYP11B2 and hypertension in Japanese: the Suita Study. Hypertens Res. 2001;24:105-9.
  190. Tsujita Y, Baba S, Yamauchi R, Mannami T, Kinoshita M, Yamamoto R, Katsuya T, Higaki J, Ogihara T, Ogata J, Iwai N. Association analyses between genetic polymorphisms of endothelial nitric oxide synthase gene and hypertension in Japanese: The Suita Study. J Hypertens. 2001;19:1941-8.
  191. Takagi S, Baba S, Iwai N, Fukuda M, Katsuya T, Higaki J, Mannami T, Ogata J, Goto Y, Ogihara T. The aldehyde dehydrogenase 2 gene is a risk factor for hypertension in Japanese but does not alter the sensitivity to pressor effects of alcohol: the Suita study. Hypertens Res. 2001;24:365-70.
  192. Matsubara M, Kikuya M, Ohkubo T, Metoki H, Omori F, Fujiwara T, Suzuki M, Michimata M, Hozawa A, Katsuya T, Higaki J, Tsuji I, Araki T, Ogihara T, Satoh H, Hisamichi S, Nagai K, Kitaoka H, Imai Y. Aldosterone synthase gene (CYP11B2) C-334T polymorphism, ambulatory blood pressure and nocturnal decline in blood pressure in the general Japanese population: the Ohasama Study. J Hypertens. 2001;19:2179-84.
  193. Mannami T, Katsuya T, Baba S, Inamoto N, Ishikawa K, Higaki J, Ogihara T, Ogata J. Low potentiality of angiotensin-converting enzyme gene insertion/deletion polymorphism as a useful predictive marker for carotid atherogenesis in a large general population of a Japanese city: the Suita study. Stroke. 2001;32:1250-6.
  194. Katsuya T, Ogihara T. Current genetics of essential hypertension. Curr Hypertens Rep. 2001;3:1-2.
  195. Katsuya T, Iwashima Y, Sugimoto K, Motone M, Asai T, Fukuda M, Fu Y, Hatanaka Y, Ohishi M, Rakugi H, Higaki J, Ogihara T. Effects of antihypertensive drugs and gene variants in the renin-angiotensin system. Hypertens Res. 2001;24:463-7.
  196. Iwai N, Baba S, Mannami T, Katsuya T, Higaki J, Ogihara T, Ogata J. Association of sodium channel gamma-subunit promoter variant with blood pressure. Hypertension. 2001;38:86-9.
  197. Ishikawa K, Baba S, Katsuya T, Iwai N, Asai T, Fukuda M, Takiuchi S, Fu Y, Mannami T, Ogata J, Higaki J, Ogihara T. T+31C polymorphism of angiotensinogen gene and essential hypertension. Hypertension. 2001;37:281-5.
  198. Higaki J, Katsuya T, Morishita R, Ogihara T. Symposium on the etiology of hypertension--summarizing studies in 20th century. 1. Hypertension and genes. Intern Med. 2001;40:144-7.
  199. Fu Y, Katsuya T, Higaki J, Asai T, Fukuda M, Takiuchi S, Hatanaka Y, Rakugi H, Ogihara T. A common mutation of low-density lipoprotein receptor gene is associated with essential hypertension among Japanese. J Hum Hypertens. 2001;15:125-30.
  200. Fu Y, Katsuya T, Asai T, Fukuda M, Inamoto N, Iwashima Y, Sugimoto K, Rakugi H, Higaki J, Ogihara T. Lack of correlation between Mbo I restriction fragment length polymorphism of renin gene and essential hypertension in Japanese. Hypertens Res. 2001;24:295-8.
  201. Asai T, Ohkubo T, Katsuya T, Higaki J, Fu Y, Fukuda M, Hozawa A, Matsubara M, Kitaoka H, Tsuji I, Araki T, Satoh H, Hisamichi S, Imai Y, Ogihara T. Endothelin-1 gene variant associates with blood pressure in obese Japanese subjects: the Ohasama Study. Hypertension. 2001;38:1321-4.
  202. Takami S, Imai Y, Katsuya T, Ohkubo T, Tsuji I, Nagai K, Satoh H, Hisamichi S, Higaki J, Ogihara T. Gene polymorphism of the renin-angiotensin system associates with risk for lacunar infarction. The Ohasama study. Am J Hypertens. 2000;13:121-7.
  203. Sato N, Katsuya T, Nakagawa T, Ishikawa K, Fu Y, Asai T, Fukuda M, Suzuki F, Nakamura Y, Higaki J, Ogihara T. Nine polymorphisms of angiotensinogen gene in the susceptibility to essential hypertension. Life Sci. 2000;68:259-72.
  204. Ohishi M, Rakugi H, Miki T, Katsuya T, Okamura A, Kamide K, Nakata Y, Takami S, Ikegami H, Yanagitani Y, Tabuchi Y, Kumahara Y, Higaki J, Ogihara T. Deletion polymorphism of angiotensin-converting enzyme gene is associated with postprandial hyperglycaemia in individuals undergoing general check-up. Clin Exp Pharmacol Physiol. 2000;27:483-7.
  205. Ogihara T, Katsuya T, Higaki J. Genetic analysis of essential hypertension in Japanese populations. Ann N Y Acad Sci. 2000;902:8-16.
  206. Matsubara M, Ohkubo T, Michimata M, Hozawa A, Ishikawa K, Katsuya T, Nagai K, Tsuji I, Higaki J, Araki T, Satoh H, Hisamichi S, Ito S, Ogihara T, Imai Y. Japanese individuals do not harbor the T594M mutation but do have the P592S mutation in the C-terminus of the beta-subunit of the epithelial sodium channel: the Ohasama study. J Hypertens. 2000;18:861-6.
  207. Katsuya T, Sato N, Asai T, Fukuda M, Takiuchi S, Fu Y, Hanayama R, Moriguchi A, Rakugi H, Higaki J, Ogihara T. Association of polymorphism in the promoter region of the apolipoprotein E gene with diastolic blood pressure in normotensive Japanese. Hypertens Res. 2000;23:271-5.
  208. Ishikawa K, Imai Y, Katsuya T, Ohkubo T, Tsuji I, Nagai K, Takami S, Nakata Y, Satoh H, Hisamichi S, Higaki J, Ogihara T. Human G-protein beta3 subunit variant is associated with serum potassium and total cholesterol levels but not with blood pressure. Am J Hypertens. 2000;13:140-5.
  209. Higaki J, Baba S, Katsuya T, Sato N, Ishikawa K, Mannami T, Ogata J, Ogihara T. Deletion allele of angiotensin-converting enzyme gene increases risk of essential hypertension in Japanese men : the Suita Study. Circulation. 2000;101:2060-5.
  210. Okamura A, Ohishi M, Rakugi H, Katsuya T, Yanagitani Y, Takiuchi S, Taniyama Y, Moriguchi K, Ito H, Higashino Y, Fujii K, Higaki J, Ogihara T. Pharmacogenetic analysis of the effect of angiotensin-converting enzyme inhibitor on restenosis after percutaneous transluminal coronary angioplasty. Angiology. 1999;50:811-22.
  211. Iwai N, Katsuya T, Ishikawa K, Mannami T, Ogata J, Higaki J, Ogihara T, Tanabe T, Baba S. Human prostacyclin synthase gene and hypertension : the Suita Study. Circulation. 1999;100:2231-6.
  212. Takemoto Y, Sakatani M, Takami S, Tachibana T, Higaki J, Ogihara T, Miki T, Katsuya T, Tsuchiyama T, Yoshida A, Yu H, Tanio Y, Ueda E. Association between angiotensin II receptor gene polymorphism and serum angiotensin converting enzyme (SACE) activity in patients with sarcoidosis. Thorax. 1998;53:459-62.
  213. Takami S, Katsuya T, Rakugi H, Sato N, Nakata Y, Kamitani A, Miki T, Higaki J, Ogihara T. Angiotensin II type 1 receptor gene polymorphism is associated with increase of left ventricular mass but not with hypertension. Am J Hypertens. 1998;11:316-21.
  214. Nakata Y, Katsuya T, Takami S, Sato N, Fu Y, Ishikawa K, Takiuchi S, Rakugi H, Miki T, Higaki J, Ogihara T. Methylenetetrahydrofolate reductase gene polymorphism: relation to blood pressure and cerebrovascular disease. Am J Hypertens. 1998;11:1019-23.
  215. Nakamura S, Moriguchi A, Morishita R, Aoki M, Yo Y, Hayashi S, Nakano N, Katsuya T, Nakata S, Takami S, Matsumoto K, Nakamura T, Higaki J, Ogihara T. A novel vascular modulator, hepatocyte growth factor (HGF), as a potential index of the severity of hypertension. Biochem Biophys Res Commun. 1998;242:238-43.
  216. Ishikawa K, Katsuya T, Sato N, Nakata Y, Takami S, Takiuchi S, Fu Y, Higaki J, Ogihara T. No association between alpha-adducin 460 polymorphism and essential hypertension in a Japanese population. Am J Hypertens. 1998;11:502-6.
  217. Sato N, Katsuya T, Rakugi H, Takami S, Nakata Y, Miki T, Higaki J, Ogihara T. Association of variants in critical core promoter element of angiotensinogen gene with increased risk of essential hypertension in Japanese. Hypertension. 1997;30:321-5.
  218. Nakata Y, Katsuya T, Rakugi H, Takami S, Sato N, Kamide K, Ohishi M, Miki T, Higaki J, Ogihara T. Polymorphism of angiotensin converting enzyme, angiotensinogen, and apolipoprotein E genes in a Japanese population with cerebrovascular disease. Am J Hypertens. 1997;10:1391-5.
  219. Katsuya T, Horiuchi M, Minami S, Koike G, Santoro NF, Hsueh AJ, Dzau VJ. Genomic organization and polymorphism of human angiotensin II type 2 receptor: no evidence for its gene mutation in two families of human premature ovarian failure syndrome. Mol Cell Endocrinol. 1997;127:221-8.
  220. Kamide K, Rakugi H, Nakano N, Ohishi M, Nakata Y, Takami S, Katsuya T, Higaki J, Ogihara T. Insulin resistance is related to silent cerebral infarction in patients with essential hypertension. Am J Hypertens. 1997;10:1245-9.
  221. Haywood GA, Gullestad L, Katsuya T, Hutchinson HG, Pratt RE, Horiuchi M, Fowler MB. AT1 and AT2 angiotensin receptor gene expression in human heart failure. Circulation. 1997;95:1201-6.
  222. Wu DA, Bu X, Warden CH, Shen DD, Jeng CY, Sheu WH, Fuh MM, Katsuya T, Dzau VJ, Reaven GM, Lusis AJ, Rotter JI, Chen YD. Quantitative trait locus mapping of human blood pressure to a genetic region at or near the lipoprotein lipase gene locus on chromosome 8p22. J Clin Invest. 1996;97:2111-8.
  223. Takami S, Higaki J, Miki T, Katsuya T, Nakata Y, Rakugi H, Serikawa T, Ogihara T. Analysis and comparison of new candidate loci for hypertension between genetic hypertensive rat strains. Hypertens Res. 1996;19:51-6.
  224. Nakata Y, Katsuya T, Rakugi H, Takami S, Ohishi M, Kamino K, Higaki J, Tabuchi Y, Kumahara Y, Miki T, Ogihara T. Polymorphism of the apolipoprotein E and angiotensin-converting enzyme genes in Japanese subjects with silent myocardial ischemia. Hypertension. 1996;27:1205-9.
  225. Katsuya T, Takami S, Higaki J, Serikawa T, Mikami H, Miki T, Ogihara T. Gap junction protein locus on chromosome 18 cosegregates with body weight in the spontaneously hypertensive rat. Hypertens Res. 1995;18:63-7.
  226. Katsuya T, Horiuchi M, Chen YD, Koike G, Pratt RE, Dzau VJ, Reaven GM. Relations between deletion polymorphism of the angiotensin-converting enzyme gene and insulin resistance, glucose intolerance, hyperinsulinemia, and dyslipidemia. Arterioscler Thromb Vasc Biol. 1995;15:779-82.
  227. Katsuya T, Koike G, Yee TW, Sharpe N, Jackson R, Norton R, Horiuchi M, Pratt RE, Dzau VJ, MacMahon S. Association of angiotensinogen gene T235 variant with increased risk of coronary heart disease. Lancet. 1995;345:1600-3.
  228. Kamino K, Nagano K, Katsuya T, Nishiwaki Y, Takeda M, Tanabe H, Nishimura T, Ii K, Fujimoto K, Tsujimura R, et al. Linkage and haplotype analysis of familial early-onset Alzheimer disease in Japanese population. Jpn J Hum Genet. 1995;40:229-41.
  229. Morishita R, Rakugi H, Higaki J, Tomita N, Nakamura F, Yu H, Katsuya T, Mikami H, Ogihara T. Differential regulation of brain angiotensin II in genetically hypertensive and normotensive rats after nephrectomy. Blood Press. 1994;3:265-9.
  230. Mullan M, Tsuji S, Miki T, Katsuya T, Naruse S, Kaneko K, Shimizu T, Kojima T, Nakano I, Ogihara T, et al. Clinical comparison of Alzheimer's disease in pedigrees with the codon 717 Val-->Ile mutation in the amyloid precursor protein gene. Neurobiol Aging. 1993;14:407-19.
  231. Katsuya T, Higaki J, Zhao Y, Miki T, Mikami H, Serikawa T, Ogihara T. A neuropeptide Y locus on chromosome 4 cosegregates with blood pressure in the spontaneously hypertensive rat. Biochem Biophys Res Commun. 1993;192:261-7.
  232. Higashimori K, Zhao Y, Higaki J, Kamitani A, Katsuya T, Nakura J, Miki T, Mikami H, Ogihara T. Association analysis of a polymorphism of the angiotensin converting enzyme gene with essential hypertension in the Japanese population. Biochem Biophys Res Commun. 1993;191:399-404.
  233. Katsuya T, Higaki J, Miki T, Kohara K, Yagisawa H, Tanase H, Mikami H, Serikawa T, Nojima H, Ogihara T. Hypotensive effect associated with a phospholipase C-delta 1 gene mutation in the spontaneously hypertensive rat. Biochem Biophys Res Commun. 1992;187:1359-66.
  234. Yoshioka K, Miki T, Katsuya T, Ogihara T, Sakaki Y. The 717Val----Ile substitution in amyloid precursor protein is associated with familial Alzheimer's disease regardless of ethnic groups. Biochem Biophys Res Commun. 1991;178:1141-6.
  235. Katsuya T, Higaki J, Miki T, Nakura J, Ikegami H, Morishita R, Nagano M, Higashimori K, Nakamura F, Mikami H, et al. Substrain comparison of genetically hypertensive rats using DNA fingerprinting, and genetic analysis of blood pressure in the inbred rats. Tohoku J Exp Med. 1991;165:253-60
Motokuni
Aoki		 Tomohiro
Katsuya		 Naoyuki
Sato		 Yoshiaki
Taniyama		 Naotaka
Hashiya		 Junya
Azuma
Hirofumi
Makino		 Hideo
Shimizu		 Kazuma
Iekushi		 Shin-ichiro
Hayashi		 Takashi
Miyake		 Katsutoshi
Tamura
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