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Specially appointed researchers group
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Tomohiro Katsuya Kazuma Iekushi
Tomohiro Katsuya
  1. Popov S, Silveira A, Wågsäter D, Takemori H, Oguro R, Matsumoto S, Sugimoto K, Kamide K, Hirose T, Satoh M, Metoki H, Kikuya M, Ohkubo T, Katsuya T, Rakugi H, Imai Y, Sanchez F, Leosdottir M, Syvänen AC, Hamsten A, Melander O, Bertorello AM. Salt-inducible kinase 1 influences Na+,K+-ATPase activity in vascular smooth muscle cells and associates with variations in blood pressure. J Hypertens. 2011;29:2395-403.
  2. Takeuchi F, Yokota M, Yamamoto K, Nakashima E, Katsuya T, Asano H, Isono M, Nabika T, Sugiyama T, Fujioka A, Awata N, Ohnaka K, Nakatochi M, Kitajima H, Rakugi H, Nakamura J, Ohkubo T, Imai Y, Shimamoto K, Yamori Y, Yamaguchi S, Kobayashi S, Takayanagi R, Ogihara T, Kato N. Genome-wide association study of coronary artery disease in the Japanese. Eur J Hum Genet. 2011 (in press)
  3. Nakagami H, Shimamura M, Miyake T, Shimosato T, Minobe N, Moritani T, Kiomy Osako M, Nakagami F, Koriyama H, Kyutoku M, Shimizu H, Katsuya T, Morishita R. Nifedipine prevents hepatic fibrosis in a non-alcoholic steatohepatitis. Mol Med Report. 2011 (in press)
  4. Hirose T, Totsune K, Nakashige Y, Metoki H, Kikuya M, Ohkubo T, Hara A, Satoh M, Inoue R, Asayama K, Kondo T, Kamide K, Katsuya T, Ogihara T, Izumi SI, Rakugi H, Takahashi K, Imai Y. Influence of adrenomedullin 2/intermedin gene polymorphism on blood pressure, renal function and silent cerebrovascular lesions in Japanese: the Ohasama study. Hypertens Res. 2011 (in press)
  5. Nakayama H, Nagai H, Matsumoto K, Oguro R, Sugimoto K, Kamide K, Ohishi M, Katsuya T, Okamoto H, Maeda M, Komamura K, Azuma J, Rakugi H, Fujio Y. Association between osteopontin promoter variants and diastolic dysfunction in hypertensive heart in the Japanese population. Hypertens Res. 2011 (in press)
  6. Kato N, Takeuchi F, Tabara Y, Kelly TN, Go MJ, Sim X, Tay WT, Chen CH, Zhang Y, Yamamoto K, Katsuya T, Yokota M, Kim YJ, Ong RT, Nabika T, Gu D, Chang LC, Kokubo Y, Huang W, Ohnaka K, Yamori Y, Nakashima E, Jaquish CE, Lee JY, Seielstad M, Isono M, Hixson JE, Chen YT, Miki T, Zhou X, Sugiyama T, Jeon JP, Liu JJ, Takayanagi R, Kim SS, Aung T, Sung YJ, Zhang X, Wong TY, Han BG, Kobayashi S, Ogihara T, Zhu D, Iwai N, Wu JY, Teo YY, Tai ES, Cho YS, He J. Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. Nat Genet. 2011;43:531-8.
  7. Takeuchi F, Yamamoto K, Katsuya T, Nabika T, Sugiyama T, Fujioka A, Isono M, Ohnaka K, Fujisawa T, Nakashima E, Ikegami H, Nakamura J, Yamori Y, Yamaguchi S, Kobayashi S, Ogihara T, Takayanagi R, Kato N. Association of genetic variants for susceptibility to obesity with type 2 diabetes in Japanese individuals. Diabetologia. 2011;54:1350-9.
  8. Hirose T, Hashimoto M, Totsune K, Metoki H, Hara A, Satoh M, Kikuya M, Ohkubo T, Asayama K, Kondo T, Kamide K, Katsuya T, Ogihara T, Izumi S, Rakugi H, Takahashi K, Imai Y. Association of (pro)renin receptor gene polymorphisms with lacunar infarction and left ventricular hypertrophy in Japanese women: the Ohasama study. Hypertens Res. 2011;34:530-535.
  9. Katsuya T, Harrap SB, Ogihara T Genetics of hypertension and cardiovascular disease. Int J Hypertens. 2011: 951254.
  10. Takeuchi F, Isono M, Nabika T, Katsuya T, Sugiyama T, Yamaguchi S, Kobayashi S, Ogihara T, Yamori Y, Fujioka A, Kato N. Confirmation of ALDH2 as a Major locus of drinking behavior and of its variants regulating multiple metabolic phenotypes in a Japanese population. Circ J. 2011;75:911-918.
  11. Sugimoto K, Katsuya T, Kamide K, Fujisawa T, Shimaoka I, Ohishi M, Morishita R, Ogihara T, Rakugi H. Promoter Polymorphism of RGS2 Gene Is Associated with Change of Blood Pressure in Subjects with Antihypertensive Treatment: The Azelnidipine and Temocapril in Hypertensive Patients with Type 2 Diabetes Study. Int J Hypertens, 2010:196307.
  12. Tabara Y, Kohara K, Kita Y, Hirawa N, Katsuya T, Ohkubo T, Hiura Y, Tajima A, Morisaki T, Miyata T, Nakayama T, Takashima N, Nakura J, Kawamoto R, Takahashi N, Hata A, Soma M, Imai Y, Kokubo Y, Okamura T, Tomoike H, Iwai N, Ogihara T, Inoue I, Tokunaga K, Johnson T, Caulfield M, Munroe P, Umemura S, Ueshima H, Miki T. Common Variants in the ATP2B1 Gene Are Associated With Susceptibility to Hypertension. The Japanese Millennium Genome Project. Hypertension, 2010;56:973-80.
  13. Koriyama H, Nakagami H, Katsuya T, Sugimoto K, Yamashita H, Takami Y, Maeda S, Kubo M, Takahashi A, Nakamura Y, Ogihara T, Rakugi H, Kaneda Y, Morishita R. Identification of Evidence Suggestive of an Association with Peripheral Arterial Disease at the OSBPL10 Locus by Genome-Wide Investigation in the Japanese Population. J Atheroscler Thromb. 2010;17:1054-62.
  14. Katsuya T, Morishita R. The challenge of stopping the knocking down of metabolic dominos upstream. Hypertens Res. 2010;33:529-530.
  15. Takeuchi F, Isono M, Katsuya T, Yamamoto K, Yokota M, Sugiyama T, Nabika T, Fujioka A, Ohnaka K, Asano H, Yamori Y, Yamaguchi S, Kobayashi S, Takayanagi R, Ogihara T, Kato N. Blood pressure and hypertension are associated with 7 loci in the Japanese population. Circulation 2010;121:2302-2309.
  16. Oguro R, Kamide K, Kokubo Y, Shimaoka I, Congrains A, Horio T, Hanada H, Ohishi M, Katsuya T, Okamura T, Miyata T, Kawano Y, Rakugi H. Association of carotid atherosclerosis with genetic polymorphisms of the klotho gene in patients with hypertension. Geriatr Gerontol Int. 2010;10:311-8.
  17. Michishita T, Kobayashi S, Katsuya T, Ogihara T, Kawabuchi K. Evaluation of the antiobesity effects of an amino acid mixture and conjugated linoleic acid on conjugated overweight humans: a randomized, double-blind, placebo-controlled trial. J Int. Med. Res. 2010;38:844-859.
  18. Koriyama H, Nakagami H, Katsuya T, Akasaka H, Saitoh S, Shimamoto K, Ogihara T, Kaneda Y, Morishita R, Rakugi H. Variation in OSBPL10 is associated with dyslipidemia. Hypertens Res. 2010;33:511-514.
  19. Shimaoka I, Kamide K, Ohishi M, Katsuya T, Akasaka H, Saitoh S, Sugimoto K, Oguro R, Congrains A, Fujisawa T, Shimamoto K, Ogihara T, Rakugi H. Association of gene polymorphism of the fat-mass and obesity-associated gene with insulin resistance in Japanese. Hypertens Res. 2010;33:214-218.
  20. Takeuchi F, Katsuya T, Chakrewarthy S, Yamamoto K, Fujioka A, Serizawa M, Fujisawa T, Nakashima E, Ohnaka K, Ikegami H, Sugiyama T, Nabika T, Kasturiratne A, Yamaguchi S, Kono S, Takayanagi R, Yamori Y, Kobayashi S, Ogihara T, de Silva A, Wickremasinghe R, Kato N. Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations. Diabetologia. 2010;53:299-308.
  21. Watanabe Y, Metoki H, Ohkubo T, Katsuya T, Tabara Y, Kikuya M, Hirose T, Sugimoto K, Asayama K, Inoue R, Hara A, Obara T, Nakura J, Kohara K, Totsune K, Ogihara T, Rakugi H, Miki T, Imai Y. Accumulation of common polymorphisms is associated with development of hypertension: a 12-year follow-up from the Ohasama study. Hypertens Res. 2010;33:129-134.
  22. Takeuchi F, Nabika T, Isono M, Katsuya T, Sugiyama T, Yamaguchi S, Kobayashi S, Yamori Y, Ogihara T, Kato N. Evaluation of genetic loci influencing adult height in the Japanese population. J Hum Genet. 2009;54:749-752.
  23. Akasaka H, Katsuya T, Saitoh S, Sugimoto K, Ohnishi H, Congrains A, Ohnishi M, Ohishi M, Rakugi H, Ogihara T, Shimamoto K. A Promoter Polymorphism of Lamin A/C Gene is an Independent Genetic Predisposition to Arterial Stiffness in a Japanese General Population (The Tanno and Sobetsu Study). J Atheroscler Thromb. 2009;16:404-409.
  24. Miyanaga K, Fukuo K, Akasaka H, Katsuya T, Fukada R, Rakugi H, Kazumi T. C allele of angiotensin II type 1 receptor gene A1166C polymorphism affects plasma adiponectin concentrations in healthy young Japanese women. Hypertens Res. 2009;32:901-905.
  25. Tomiyama-Hanayama M, Rakugi H, Kohara M, Mima T, Adachi Y, Ohishi M, Katsuya T, Hoshida Y, Aozasa K, Ogihara T, Nishimoto N. Effect of Interleukin-6 Receptor Blockage on Renal Injury in Apolipoprotein E-Deficient Mice. Am J Physiol Renal Physiol. 2009;297:F679-684.
  26. Katsuya T, Morishita R, Rakugi H, Ogihrara T. Genetic basis of hypertension for the development of tailored medicine. Hypertens Res. 2009;32:643-648.
  27. Hanasaki H, Takemura Y, Fukuo K, Ohishi M, Onishi M, Yasuda O, Katsuya T, Awata N, Kato N, Ogihara T, Rakugi H. Fas promoter region gene polymorphism is associated with an increased risk for myocardial infarction. Hypertens Res. 2009;32:261-264.
  28. Ueno T, Tabara Y, Fukuda N, Tahira K, Matsumoto T, Kosuge K, Haketa A, Matsumoto K, Sato Y, Nakayama T, Katsuya T, Ogihara T, Makita Y, Hata A, Yamada M, Takahashi N, Hirawa N, Umemura S, Miki T, Soma M. Association of SLC6A9 gene variants with human essential hypertension. J Atheroscler Thromb. 2009;16:201-206.
  29. Takeuchi F, Serizawa M, Yamamoto K, Fujisawa T, Nakashima E, Ohnaka K, Ikegami H, Sugiyama T, Katsuya T, Miyagishi M, Nakashima N, Nawata H, Nakamura J, Kono S, Takayanagi R, Kato N. Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. Diabetes. 2009;58:1690-1699.
  30. Maekawa Y, Ishikawa K, Yasuda O, Oguro R, Hanasaki H, Kida I, Takemura Y, Ohishi M, Katsuya T, Rakugi H. Klotho suppresses TNF-alpha-induced expression of adhesion molecules in the endothelium and attenuates NF-kappaB activation. Endocrine. 2009;35:341-346.
  31. Tatara Y, Ohishi M, Yamamoto K, Shiota A, Hayashi N, Iwamoto Y, Takeda M, Takagi T, Katsuya T, Ogihara T, Rakugi H. Macrophage inflammatory protein-1beta induced cell adhesion with increased intracellular reactive oxygen species. J Mol Cell Cardiol. 2009;47:104-111.
  32. Tsuchihashi-Makaya M, Serizawa M, Yanai K, Katsuya T, Takeuchi F, Fujioka A, Yamori Y, Ogihara T, Kato N. Gene-environmental interaction regarding alcohol-metabolizing enzymes in the Japanese general population. Hypertens Res. 2009;32:207-213.
  33. Hirose T, Hashimoto M, Totsune K, Metoki H, Asayama K, Kikuya M, Sugimoto K, Katsuya T, Ohkubo T, Hashimoto J, Rakugi H, Takahashi K, Imai Y. Association of (pro)renin receptor gene polymorphism with blood pressure in Japanese men: the Ohasama study. Am J Hypertens. 2009;22:294-299.
  34. Sugimoto K, Akasaka H, Katsuya T, Node K, Fujisawa T, Shimaoka I, Yasuda O, Ohishi M, Ogihara T, Shimamoto K, Rakugi H. A Polymorphism Regulates CYP4A11 transcriptional activity and is associated with hypertension in a Japanese population. Hypertension. 2008;52:1142-8.
  35. Katsuya T, Ogihara T. Hypertension and risk stratification. Hypertens Res 2008;31:1271-3.
  36. Masuo K, Straznicky NE, Lambert GW, Katsuya T, Sugimoto K, Rakugi H, Socratous F, Hastings J, Lambert EA, Ogihara T, Esler MD. Leptin-receptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic nerve activation in a Caucasian male population. Hypertens Res 2008;31:1093-1100.
  37. Takami Y, Nakagami H, Morishita R, Katsuya T, Hayashi H, Mori M, Koriyama H, Baba Y, Yasuda O, Rakugi H, Ogihara T, Kaneda Y. Potential Role of CYLD (Cylindromatosis) as a Deubiquitinating Enzyme in Vascular Cells. Am J Pathol. 2008;172:818-29.
  38. Sun X, Yasuda O, Takemura Y, Kawamoto H, Higuchi M, Baba Y, Katsuya T, Fukuo K, Ogihara T, Rakugi H. Akt activation prevents Apop-1-induced death of cells. Biochem Biophys Res Commun. 2008;377:1097-101.
  39. Kohara K, Tabara Y, Nakura J, Imai Y, Ohkubo T, Hata A, Soma M, Nakayama T, Umemura S, Hirawa N, Ueshima H, Kita Y, Ogihara T, Katsuya T, Takahashi N, Tokunaga K, Miki T. Identification of hypertension-susceptibility genes and pathways by a systemic multiple candidate gene approach: the millennium genome project for hypertension. Hypertens Res. 2008;31:203-12.
  40. Ueno T, Soma M, Tabara Y, Tokunaga K, Tahira K, Fukuda N, Matsumoto K, Nakayama T, Katsuya T, Ogihara T, Makita Y, Hata A, Yamada M, Takahashi N, Hirawa N, Umemura S, Miki T. Association between Fatty Acid binding protein 3 gene variants and essential hypertension in humans. Am J Hypertens. 2008;21:691-695.
  41. Mashimo Y, Suzuki Y, Hatori K, Tabara Y, Miki T, Tokunaga K, Katsuya T, Ogihara T, Yamada M, Takahashi N, Makita Y, Nakayama T, Soma M, Hirawa N, Umemura S, Ohkubo T, Imai Y, Hata A. Association of TNFRSF4 gene polymorphisms with essential hypertension. J Hypertens. 2008;26:902-13.
  42. Kato N, Miyata T, Tabara Y, Katsuya T, Yanai K, Hanada H, Kamide K, Nakura J, Kohara K, Takeuchi F, Mano H, Yasunami M, Kimura A, Kita Y, Ueshima H, Nakayama T, Soma M, Hata A, Fujioka A, Kawano Y, Nakao K, Sekine A, Yoshida T, Nakamura Y, Saruta T, Ogihara T, Sugano S, Miki T, Tomoike H. High-density association study and nomination of susceptibility genes for hypertension in the Japanese National Project. Hum Mol Genet. 2008;17:617-27
  43. Nakagami H, Kikuchi Y, Katsuya T, Morishita R, Akasaka H, Saitoh S, Rakugi H, Kaneda Y, Shimamoto K, Ogihara T. Gene polymorphism of myospryn (cardiomyopathy-associated 5) is associated with left ventricular wall thickness in patients with hypertension. Hypertens Res. 2007;30:1239-46.
  44. Ohishi M, Takagi T, Ito N, Tatara Y, Hayashi N, Shiota A, Iwamoto Y, Katsuya T, Rakugi H, Ogihara T. Renal protective effect in hypertensive patients -high doses of angiotensin II receptor blocker (HARB) study-. Hypertens Res 2007;30:1187-92.
  45. Ohishi M, Takagi T, Ito N, Terai M, Tatara Y, Hayashi N, Shiota A, Katsuya T, Rakugi H, Ogihara T. Renal-protective effect of T-and L-type calcium channel blockers in hypertensive patients: an Amlodipine-to-Benidipine Changeover (ABC) study. Hypertens Res. 2007;30:797-806.
  46. Nakano N, Hori H, Abe M, Shibata H, Arimura T, Sasaoka T, Sawabe M, Chida K, Arai T, Nakahara KI, Kubo T, Sugimoto K, Katsuya T, Ogihara T, Doi Y, Izumi T, Kimura A. Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 2007;293:H3396-403.
  47. Ch'ng ES, Hoshida Y, Iizuka N, Morii E, Ikeda JI, Yamamoto A, Tomita Y, Hanasaki H, Katsuya T, Maeda K, Ohishi M, Rakugi H, Ogihara T, Aozasa K. Composite malignant pheochromocytoma with malignant peripheral nerve sheath tumour: a case with 28 years of tumour-bearing history. Histopathology. 2007;51:420-2.
  48. Masuo K, Katsuya T, Sugimoto K, Kawaguchi H, Rakugi H, Ogihara T, Tuck ML. High plasma norepinephrine levels associated with beta2-adrenoceptor polymorphisms predict future renal damage in nonobese normotensive individuals. Hypertens Res. 2007;30:503-11.
  49. Takami Y, Nakagami H, Morishita R, Katsuya T, Cui TX, Ichikawa T, Saito Y, Hayashi H, Kikuchi Y, Nishikawa T, Baba Y, Yasuda O, Rakugi H, Ogihara T, Kaneda Y. Ubiquitin carboxyl-terminal hydrolase L1, a novel deubiquitinating enzyme in the vasculature, attenuates NF-kappaB activation. Arterioscler Thromb Vasc Biol. 2007;27:2184-90.
  50. Katsuya T, Rakugi H, Ogihara T. Inflammation and salt sensitivity in the early state of hypertension. Hypertens Res 2007;30:105-7.
  51. Akasaka H, Katsuya T, Saitoh S, Sugimoto K, Fu Y, Takagi T, Ohnishi H, Rakugi H, Ura N, Shimamoto K, Ogihara T. Effects of angiotensin II type 1 receptor gene polymorphisms on insulin resistance in Japanese general population: the Tannno-Sobetsu Study. Hypertens Res 2006;29:961-7.
  52. Kawaguchi H, Masuo K, Katsuya T, Sugimoto K, Rakugi H, Ogihara T, Tuck ML. β2-and β3-Adrenoceptor polymorphisms relate to subsequent weight gain and blood pressure elevation in obese normotensive individuals. Hypertens Res 2006;29:951-9.
  53. Yuan M, Ohishi M, Ito N, Sugimoto K, Takagi T, Terai M, Katsuya T, Rakugi H, Wu Z, Ogihara T. Genetic influences of β-adrenoceptor polymorphisms on arterial functional changes and cardiac remodeling in hypertensive patients. Hypertens Res 2006;29:875-81
  54. Masuo K, Katsuya T, Kawaguchi H, Fu Y, Rakugi H, Ogihara T, Tuck ML. Beta2-adrenoceptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic activation. Am J Hypertens. 2006;19:1084-91.
  55. Nakayama T, Kuroi N, Sano M, Tabara Y, Katsuya T, Ogihara T, Makita Y, Hata A, Yamada M, Takahashi N, Hirawa N, Umemura S, Miki T, Soma M. Mutation of the follicle-stimulating hormone receptor gene 5'-untranslated region associated with female hypertension. Hypertension. 2006;48:512-8.
  56. Yamamoto K, Ohishi M, Katsuya T, Ito N, Ikushima M, Kaibe M, Tatara Y, Shiota A, Sugano S, Takeda S, Rakugi H, Ogihara T. Deletion of angiotensin-converting enzyme 2 accelerates pressure overload-induced cardiac dysfunction by increasing local angiotensin II. Hypertension. 2006;47:718-26.
  57. Xu R, Ishikawa K, Katsuya T, Fu Y, Akasaka H, Ikushima M, Chihara Y, Ura N, Shimamoto K, Rakugi H, Ogihara T. Association between senescence-related uncoupling protein 2 gene polymorphisms and abdominal obesity in Japanese subjects: the Tanno and Sobetsu Study. Geriatr Gerontol Int. 2006;6:15-9.
  58. Masuo K, Katsuya T, Kawaguchi H, Fu Y, Rakugi H, Ogihara T, Tuck ML. Rebound weight gain as associated with high plasma norepinephrine levels that are mediated through polymorphisms in the beta2-adrenoceptor. Am J Hypertens. 2005;18:1508-1516
  59. Masuo K, Katsuya T, Fu Y, et al. β2- and β3-adrenergic receptor polymorphisms are related to the onset of weight gain and blood pressure elevation over 5 Years. Circulation. 2005;111:3429-4.
  60. Masuo K, Katsuya T, Fu Y, Rakugi H, Ogihara T, Tuck ML. Beta2-adrenoceptor polymorphisms relate to insulin resistance and sympathetic overactivity as early markers of metabolic disease in nonobese, normotensive individuals. Am J Hypertens. 2005;18:1009-1014.
  61. Iwashima Y, Katsuya T, Ishikawa K, et al. Association of hypoadiponectinemia with smoking habit in men. Hypertension. 2005;45:1094-1100.
  62. Masuo K, Katsuya T, Fu Y, et al. Lys418Asn polymorphism of the α2-adrenoceptor gene relates to serum uric acid levels but not to insulin sensitivity. Hypertension 2005;46:144-150.
  63. Masuo K, Katsuya T, Ogihara T, Tuck ML. Acute hyperinsulinemia reduces plasma leptin levels in insulin-sensitive Japanese men. Am J Hypertens. 2005;18:235-43.
  64. Fu Y, Katsuya T, Matsuo A, Yamamoto K, Akasaka H, Takami Y, Iwashima Y, Sugimoto K, Ishikawa K, Ohishi M, Rakugi H, Ogihara T. Relationship of bradykinin B2 receptor gene polymorphism with essential hypertension and left ventricular hypertrophy. Hypertens Res. 2004:27:933-8
  65. Matsuo A, Katsuya T, Ishikawa K, Sugimoto K, Iwashima Y, Yamamoto K, Ohishi M, Rakugi H, Ogihara T. G2736A polymorphism of thiazide-sensitive Na-Cl cotransporter gene predisposes to hypertension in young women. J Hypertens. 2004;22:2123-7.
  66. Sugimoto K, Katsuya T, Ohkubo T, Hozawa A, Yamamoto K, Matsuo A, Rakugi H, Tsuji I, Imai Y, Ogihara T. Association between angiotensin II type 1 receptor gene polymorphism and essential hypertension: the Ohasama Study. Hypertens Res. 2004;27:551-6.
  67. Iwashima Y, Katsuya T, Ishikawa K, Ouchi N, Ohishi M, Sugimoto K, Fu Y, Motone M, Yamamoto K, Matsuo A, Ohashi K, Kihara S, Funahashi T, Rakugi H, Matsuzawa Y, Ogihara T. Hypoadiponectinemia is an independent risk factor for hypertension. Hypertension. 2004;43:1318-23.
  68. Motone M, Katsuya T, Ishikawa K, Iwashima Y, Sugimoto K, Yamamoto K, Fu Y, Matsuo A, Ohishi M, Rakugi H, Ogihara T. Association between hepatocyte growth factor gene polymorphism and essential hypertension. Hypertens Res. 2004;27:247-51.
  69. Fukuchi K, Katsuya T, Sugimoto K, Kuremura M, Kim HD, Li L, Ogihara T. LMNA mutation in a 45 year old Japanese subject with Hutchinson-Gilford progeria syndrome. J Med Genet. 2004;41:e67.
  70. Ji Q, Ikegami H, Fujisawa T, Kawabata Y, Ono M, Nishino M, Ohishi M, Katsuya T, Rakugi H, Ogihara T. A common polymorphism of uncoupling protein 2 gene is associated with hypertension. J Hypertens. 2004;22:97-102.
  71. Ogihara T, Katsuya T, Ishikawa K, Matsuo A, Rakugi H, Shoji M, Yasujima M. Hypertension in a patient with Gitelman's syndrome. J Hum Hypertens. 2004;8:677-9.
  72. Ohashi K, Ouchi N, Kihara S, Funahashi T, Nakamura T, Sumitsuji S, Kawamoto T, Matsumoto S, Nagaretani H, Kumada M, Okamoto Y, Nishizawa H, Kishida K, Maeda N, Hiraoka H, Iwashima Y, Ishikawa K, Ohishi M, Katsuya T, Rakugi H, Ogihara T, Matsuzawa Y. Adiponectin I164T mutation is associated with the metabolic syndrome and coronary artery disease. J Am Coll Cardiol. 2004;43:1195-200.
  73. Takiuchi S, Mannami T, Miyata T, Kamide K, Tanaka C, Kokubo Y, Koyama Y, Inamoto N, Katsuya T, Iwai N, Kawano Y, Ogihara T, Tomoike H. Identification of 21 single nucleotide polymorphisms in human hepatocyte growth factor gene and association with blood pressure and carotid atherosclerosis in the Japanese population. Atherosclerosis. 2004;173:301-7.
  74. Katsuya T, Sugimoto K, Hozawa A, Ohkubo T, Yamamoto K, Matsuo A, Ishikawa K, Matsubara M, Rakugi H, Tsuji I, Imai Y, Ogihara T. Genetic risk factors for cerebral infarction using data from a large scale genetic epidemiological study: the Ohasama Study. Geriat Gerontol Int. 2003;3:150-3.
  75. Katsuya T, Ogihara T. Future medicine in the post-genome age -Targeting tailoed medicine for hypertension-. JMAJ. 2003;46:327-32.
  76. Katsuya T, Ishikawa K, Sugimoto K, Rakugi H, Ogihara T. Salt sensitivity of Japanese from the viewpoint of gene polymorphism. Hypertens Res. 2003;26:521-5.
  77. Inamoto N, Katsuya T, Kokubo Y, Mannami T, Asai T, Baba S, Ogata J, Tomoike H, Ogihara T. Association of methylenetetrahydrofolate reductase gene polymorphism with carotid atherosclerosis depending on smoking status in a Japanese general population. Stroke. 2003;34:1628-33.
  78. Matsubara M, Metoki H, Katsuya T, Kikuya M, Suzuki M, Michimata M, Araki T, Hozawa A, Tsuji I, Ogihara T, Imai Y. T+31C polymorphism (M235T) of the angiotensinogen gene and home blood pressure in the Japanese general population: the Ohasama Study. Hypertens Res. 2003;26:47-52.
  79. Kikuya M, Sugimoto K, Katsuya T, Suzuki M, Sato T, Funahashi J, Katoh R, Kazama I, Michimata M, Araki T, Hozawa A, Tsuji I, Ogihara T, Yanagisawa T, Imai Y, Matsubara M. A/C1166 gene polymorphism of the angiotensin II type 1 receptor (AT1) and ambulatory blood pressure: the Ohasama Study. Hypertens Res. 2003;26:141-5.
  80. Sugimoto K, Hozawa A, Katsuya T, Matsubara M, Ohkubo T, Tsuji I, Motone M, Higaki J, Hisamachi S, Imai Y, Ogihara T. alpha-Adducin Gly460Trp polymorphism is associated with low renin hypertension in younger subjects in the Ohasama study. J Hypertens. 2002;20:1779-84.
  81. Shintani M, Ikegami H, Fujisawa T, Kawaguchi Y, Ohishi M, Katsuya T, Higaki J, Shimamoto K, Ogihara T. Leptin gene polymorphism is associated with hypertension independent of obesity. J Clin Endocrinol Metab. 2002;87:2909-12.
  82. Okuda T, Sumiya T, Mizutani K, Tago N, Miyata T, Tanabe T, Kato H, Katsuya T, Higaki J, Ogihara T, Tsujita Y, Iwai N, Muzutani K. Analyses of differential gene expression in genetic hypertensive rats by microarray. Hypertens Res. 2002;25:249-55.
  83. Morimoto S, Okaishi K, Onishi M, Katsuya T, Yang J, Okuro M, Sakurai S, Onishi T, Ogihara T. Deletion allele of the angiotensin-converting enzyme gene as a risk factor for pneumonia in elderly patients. Am J Med. 2002;112:89-94.
  84. Mizutani K, Sugimoto K, Okuda T, Katsuya T, Miyata T, Tanabe T, Higaki J, Ogihara T, Yamori Y, Tsujita Y, Tago N, Iwai N. Kynureninase is a novel candidate gene for hypertension in spontaneously hypertensive rats. Hypertens Res. 2002;25:135-40.
  85. Matsubara M, Suzuki M, Fujiwara T, Kikuya M, Metoki H, Michimata M, Araki T, Kazama I, Satoh T, Hashimoto J, Hozawa A, Ohkubo T, Tsuji I, Katsuya T, Higaki J, Ogihara T, Satoh H, Imai Y. Angiotensin-converting enzyme I/D polymorphism and hypertension: the Ohasama study. J Hypertens. 2002;20:1121-6.
  86. Komai N, Ohishi M, Moriguchi A, Yanagitani Y, Jinno T, Matsumoto K, Katsuya T, Rakugi H, Higaki J, Ogihara T. Low-dose doxazosin improved aortic stiffness and endothelial dysfunction as measured by noninvasive evaluation. Hypertens Res. 2002;25:5-10.
  87. Katsuya T, Baba S, Ishikawa K, Mannami T, Fu Y, Inamoto N, Asai T, Fukuda M, Higaki J, Ogata J, Ogihara T. Epsilon 4 allele of apolipoprotein E gene associates with lower blood pressure in young Japanese subjects: the Suita Study. J Hypertens. 2002;20:2017-21.
  88. Iwai N, Katsuya T, Mannami T, Higaki J, Ogihara T, Kokame K, Ogata J, Baba S. Association between SAH, an acyl-CoA synthetase gene, and hypertriglyceridemia, obesity, and hypertension. Circulation. 2002;105:41-7.
  89. Fukuda M, Ohkubo T, Katsuya T, Hozawa A, Asai T, Matsubara M, Kitaoka H, Tsuji I, Araki T, Satoh H, Higaki J, Hisamichi S, Imai Y, Ogihara T. Association of a mast cell chymase gene variant with HDL cholesterol, but not with blood pressure in the Ohasama study. Hypertens Res. 2002;25:179-84.
  90. Fujiwara T, Katsuya T, Matsubara M, Mikami T, Ishikawa K, Kikuya M, Ohkubo T, Hozawa A, Michimata M, Suzuki M, Metoki H, Asayama K, Araki T, Tsuji I, Higaki J, Satoh H, Hisamichi S, Ogihara T, Imai Y. T+31C polymorphism of angiotensinogen gene and nocturnal blood pressure decline: the Ohasama study. Am J Hypertens. 2002;15:628-32.
  91. Tsujita Y, Iwai N, Katsuya T, Higaki J, Ogihara T, Tamaki S, Kinoshita M, Mannami T, Ogata J, Baba S. Lack of association between genetic polymorphism of CYP11B2 and hypertension in Japanese: the Suita Study. Hypertens Res. 2001;24:105-9.
  92. Tsujita Y, Baba S, Yamauchi R, Mannami T, Kinoshita M, Yamamoto R, Katsuya T, Higaki J, Ogihara T, Ogata J, Iwai N. Association analyses between genetic polymorphisms of endothelial nitric oxide synthase gene and hypertension in Japanese: The Suita Study. J Hypertens. 2001;19:1941-8.
  93. Takagi S, Baba S, Iwai N, Fukuda M, Katsuya T, Higaki J, Mannami T, Ogata J, Goto Y, Ogihara T. The aldehyde dehydrogenase 2 gene is a risk factor for hypertension in Japanese but does not alter the sensitivity to pressor effects of alcohol: the Suita study. Hypertens Res. 2001;24:365-70.
  94. Matsubara M, Kikuya M, Ohkubo T, Metoki H, Omori F, Fujiwara T, Suzuki M, Michimata M, Hozawa A, Katsuya T, Higaki J, Tsuji I, Araki T, Ogihara T, Satoh H, Hisamichi S, Nagai K, Kitaoka H, Imai Y. Aldosterone synthase gene (CYP11B2) C-334T polymorphism, ambulatory blood pressure and nocturnal decline in blood pressure in the general Japanese population: the Ohasama Study. J Hypertens. 2001;19:2179-84.
  95. Mannami T, Katsuya T, Baba S, Inamoto N, Ishikawa K, Higaki J, Ogihara T, Ogata J. Low potentiality of angiotensin-converting enzyme gene insertion/deletion polymorphism as a useful predictive marker for carotid atherogenesis in a large general population of a Japanese city: the Suita study. Stroke. 2001;32:1250-6.
  96. Katsuya T, Ogihara T. Current genetics of essential hypertension. Curr Hypertens Rep. 2001;3:1-2.
  97. Katsuya T, Iwashima Y, Sugimoto K, Motone M, Asai T, Fukuda M, Fu Y, Hatanaka Y, Ohishi M, Rakugi H, Higaki J, Ogihara T. Effects of antihypertensive drugs and gene variants in the renin-angiotensin system. Hypertens Res. 2001;24:463-7.
  98. Iwai N, Baba S, Mannami T, Katsuya T, Higaki J, Ogihara T, Ogata J. Association of sodium channel gamma-subunit promoter variant with blood pressure. Hypertension. 2001;38:86-9.
  99. Ishikawa K, Baba S, Katsuya T, Iwai N, Asai T, Fukuda M, Takiuchi S, Fu Y, Mannami T, Ogata J, Higaki J, Ogihara T. T+31C polymorphism of angiotensinogen gene and essential hypertension. Hypertension. 2001;37:281-5.
  100. Higaki J, Katsuya T, Morishita R, Ogihara T. Symposium on the etiology of hypertension--summarizing studies in 20th century. 1. Hypertension and genes. Intern Med. 2001;40:144-7.
  101. Fu Y, Katsuya T, Higaki J, Asai T, Fukuda M, Takiuchi S, Hatanaka Y, Rakugi H, Ogihara T. A common mutation of low-density lipoprotein receptor gene is associated with essential hypertension among Japanese. J Hum Hypertens. 2001;15:125-30.
  102. Fu Y, Katsuya T, Asai T, Fukuda M, Inamoto N, Iwashima Y, Sugimoto K, Rakugi H, Higaki J, Ogihara T. Lack of correlation between Mbo I restriction fragment length polymorphism of renin gene and essential hypertension in Japanese. Hypertens Res. 2001;24:295-8.
  103. Asai T, Ohkubo T, Katsuya T, Higaki J, Fu Y, Fukuda M, Hozawa A, Matsubara M, Kitaoka H, Tsuji I, Araki T, Satoh H, Hisamichi S, Imai Y, Ogihara T. Endothelin-1 gene variant associates with blood pressure in obese Japanese subjects: the Ohasama Study. Hypertension. 2001;38:1321-4.
  104. Takami S, Imai Y, Katsuya T, Ohkubo T, Tsuji I, Nagai K, Satoh H, Hisamichi S, Higaki J, Ogihara T. Gene polymorphism of the renin-angiotensin system associates with risk for lacunar infarction. The Ohasama study. Am J Hypertens. 2000;13:121-7.
  105. Sato N, Katsuya T, Nakagawa T, Ishikawa K, Fu Y, Asai T, Fukuda M, Suzuki F, Nakamura Y, Higaki J, Ogihara T. Nine polymorphisms of angiotensinogen gene in the susceptibility to essential hypertension. Life Sci. 2000;68:259-72.
  106. Ohishi M, Rakugi H, Miki T, Katsuya T, Okamura A, Kamide K, Nakata Y, Takami S, Ikegami H, Yanagitani Y, Tabuchi Y, Kumahara Y, Higaki J, Ogihara T. Deletion polymorphism of angiotensin-converting enzyme gene is associated with postprandial hyperglycaemia in individuals undergoing general check-up. Clin Exp Pharmacol Physiol. 2000;27:483-7.
  107. Ogihara T, Katsuya T, Higaki J. Genetic analysis of essential hypertension in Japanese populations. Ann N Y Acad Sci. 2000;902:8-16.
  108. Matsubara M, Ohkubo T, Michimata M, Hozawa A, Ishikawa K, Katsuya T, Nagai K, Tsuji I, Higaki J, Araki T, Satoh H, Hisamichi S, Ito S, Ogihara T, Imai Y. Japanese individuals do not harbor the T594M mutation but do have the P592S mutation in the C-terminus of the beta-subunit of the epithelial sodium channel: the Ohasama study. J Hypertens. 2000;18:861-6.
  109. Katsuya T, Sato N, Asai T, Fukuda M, Takiuchi S, Fu Y, Hanayama R, Moriguchi A, Rakugi H, Higaki J, Ogihara T. Association of polymorphism in the promoter region of the apolipoprotein E gene with diastolic blood pressure in normotensive Japanese. Hypertens Res. 2000;23:271-5.
  110. Ishikawa K, Imai Y, Katsuya T, Ohkubo T, Tsuji I, Nagai K, Takami S, Nakata Y, Satoh H, Hisamichi S, Higaki J, Ogihara T. Human G-protein beta3 subunit variant is associated with serum potassium and total cholesterol levels but not with blood pressure. Am J Hypertens. 2000;13:140-5.
  111. Higaki J, Baba S, Katsuya T, Sato N, Ishikawa K, Mannami T, Ogata J, Ogihara T. Deletion allele of angiotensin-converting enzyme gene increases risk of essential hypertension in Japanese men : the Suita Study. Circulation. 2000;101:2060-5.
  112. Okamura A, Ohishi M, Rakugi H, Katsuya T, Yanagitani Y, Takiuchi S, Taniyama Y, Moriguchi K, Ito H, Higashino Y, Fujii K, Higaki J, Ogihara T. Pharmacogenetic analysis of the effect of angiotensin-converting enzyme inhibitor on restenosis after percutaneous transluminal coronary angioplasty. Angiology. 1999;50:811-22.
  113. Iwai N, Katsuya T, Ishikawa K, Mannami T, Ogata J, Higaki J, Ogihara T, Tanabe T, Baba S. Human prostacyclin synthase gene and hypertension : the Suita Study. Circulation. 1999;100:2231-6.
  114. Takemoto Y, Sakatani M, Takami S, Tachibana T, Higaki J, Ogihara T, Miki T, Katsuya T, Tsuchiyama T, Yoshida A, Yu H, Tanio Y, Ueda E. Association between angiotensin II receptor gene polymorphism and serum angiotensin converting enzyme (SACE) activity in patients with sarcoidosis. Thorax. 1998;53:459-62.
  115. Takami S, Katsuya T, Rakugi H, Sato N, Nakata Y, Kamitani A, Miki T, Higaki J, Ogihara T. Angiotensin II type 1 receptor gene polymorphism is associated with increase of left ventricular mass but not with hypertension. Am J Hypertens. 1998;11:316-21.
  116. Nakata Y, Katsuya T, Takami S, Sato N, Fu Y, Ishikawa K, Takiuchi S, Rakugi H, Miki T, Higaki J, Ogihara T. Methylenetetrahydrofolate reductase gene polymorphism: relation to blood pressure and cerebrovascular disease. Am J Hypertens. 1998;11:1019-23.
  117. Nakamura S, Moriguchi A, Morishita R, Aoki M, Yo Y, Hayashi S, Nakano N, Katsuya T, Nakata S, Takami S, Matsumoto K, Nakamura T, Higaki J, Ogihara T. A novel vascular modulator, hepatocyte growth factor (HGF), as a potential index of the severity of hypertension. Biochem Biophys Res Commun. 1998;242:238-43.
  118. Ishikawa K, Katsuya T, Sato N, Nakata Y, Takami S, Takiuchi S, Fu Y, Higaki J, Ogihara T. No association between alpha-adducin 460 polymorphism and essential hypertension in a Japanese population. Am J Hypertens. 1998;11:502-6.
  119. Sato N, Katsuya T, Rakugi H, Takami S, Nakata Y, Miki T, Higaki J, Ogihara T. Association of variants in critical core promoter element of angiotensinogen gene with increased risk of essential hypertension in Japanese. Hypertension. 1997;30:321-5.
  120. Nakata Y, Katsuya T, Rakugi H, Takami S, Sato N, Kamide K, Ohishi M, Miki T, Higaki J, Ogihara T. Polymorphism of angiotensin converting enzyme, angiotensinogen, and apolipoprotein E genes in a Japanese population with cerebrovascular disease. Am J Hypertens. 1997;10:1391-5.
  121. Katsuya T, Horiuchi M, Minami S, Koike G, Santoro NF, Hsueh AJ, Dzau VJ. Genomic organization and polymorphism of human angiotensin II type 2 receptor: no evidence for its gene mutation in two families of human premature ovarian failure syndrome. Mol Cell Endocrinol. 1997;127:221-8.
  122. Kamide K, Rakugi H, Nakano N, Ohishi M, Nakata Y, Takami S, Katsuya T, Higaki J, Ogihara T. Insulin resistance is related to silent cerebral infarction in patients with essential hypertension. Am J Hypertens. 1997;10:1245-9.
  123. Haywood GA, Gullestad L, Katsuya T, Hutchinson HG, Pratt RE, Horiuchi M, Fowler MB. AT1 and AT2 angiotensin receptor gene expression in human heart failure. Circulation. 1997;95:1201-6.
  124. Wu DA, Bu X, Warden CH, Shen DD, Jeng CY, Sheu WH, Fuh MM, Katsuya T, Dzau VJ, Reaven GM, Lusis AJ, Rotter JI, Chen YD. Quantitative trait locus mapping of human blood pressure to a genetic region at or near the lipoprotein lipase gene locus on chromosome 8p22. J Clin Invest. 1996;97:2111-8.
  125. Takami S, Higaki J, Miki T, Katsuya T, Nakata Y, Rakugi H, Serikawa T, Ogihara T. Analysis and comparison of new candidate loci for hypertension between genetic hypertensive rat strains. Hypertens Res. 1996;19:51-6.
  126. Nakata Y, Katsuya T, Rakugi H, Takami S, Ohishi M, Kamino K, Higaki J, Tabuchi Y, Kumahara Y, Miki T, Ogihara T. Polymorphism of the apolipoprotein E and angiotensin-converting enzyme genes in Japanese subjects with silent myocardial ischemia. Hypertension. 1996;27:1205-9.
  127. Katsuya T, Takami S, Higaki J, Serikawa T, Mikami H, Miki T, Ogihara T. Gap junction protein locus on chromosome 18 cosegregates with body weight in the spontaneously hypertensive rat. Hypertens Res. 1995;18:63-7.
  128. Katsuya T, Horiuchi M, Chen YD, Koike G, Pratt RE, Dzau VJ, Reaven GM. Relations between deletion polymorphism of the angiotensin-converting enzyme gene and insulin resistance, glucose intolerance, hyperinsulinemia, and dyslipidemia. Arterioscler Thromb Vasc Biol. 1995;15:779-82.
  129. Katsuya T, Koike G, Yee TW, Sharpe N, Jackson R, Norton R, Horiuchi M, Pratt RE, Dzau VJ, MacMahon S. Association of angiotensinogen gene T235 variant with increased risk of coronary heart disease. Lancet. 1995;345:1600-3.
  130. Kamino K, Nagano K, Katsuya T, Nishiwaki Y, Takeda M, Tanabe H, Nishimura T, Ii K, Fujimoto K, Tsujimura R, et al. Linkage and haplotype analysis of familial early-onset Alzheimer disease in Japanese population. Jpn J Hum Genet. 1995;40:229-41.
  131. Morishita R, Rakugi H, Higaki J, Tomita N, Nakamura F, Yu H, Katsuya T, Mikami H, Ogihara T. Differential regulation of brain angiotensin II in genetically hypertensive and normotensive rats after nephrectomy. Blood Press. 1994;3:265-9.
  132. Mullan M, Tsuji S, Miki T, Katsuya T, Naruse S, Kaneko K, Shimizu T, Kojima T, Nakano I, Ogihara T, et al. Clinical comparison of Alzheimer's disease in pedigrees with the codon 717 Val-->Ile mutation in the amyloid precursor protein gene. Neurobiol Aging. 1993;14:407-19.
  133. Katsuya T, Higaki J, Zhao Y, Miki T, Mikami H, Serikawa T, Ogihara T. A neuropeptide Y locus on chromosome 4 cosegregates with blood pressure in the spontaneously hypertensive rat. Biochem Biophys Res Commun. 1993;192:261-7.
  134. Higashimori K, Zhao Y, Higaki J, Kamitani A, Katsuya T, Nakura J, Miki T, Mikami H, Ogihara T. Association analysis of a polymorphism of the angiotensin converting enzyme gene with essential hypertension in the Japanese population. Biochem Biophys Res Commun. 1993;191:399-404.
  135. Katsuya T, Higaki J, Miki T, Kohara K, Yagisawa H, Tanase H, Mikami H, Serikawa T, Nojima H, Ogihara T. Hypotensive effect associated with a phospholipase C-delta 1 gene mutation in the spontaneously hypertensive rat. Biochem Biophys Res Commun. 1992;187:1359-66.
  136. Yoshioka K, Miki T, Katsuya T, Ogihara T, Sakaki Y. The 717Val----Ile substitution in amyloid precursor protein is associated with familial Alzheimer's disease regardless of ethnic groups. Biochem Biophys Res Commun. 1991;178:1141-6.
  137. Katsuya T, Higaki J, Miki T, Nakura J, Ikegami H, Morishita R, Nagano M, Higashimori K, Nakamura F, Mikami H, et al. Substrain comparison of genetically hypertensive rats using DNA fingerprinting, and genetic analysis of blood pressure in the inbred rats. Tohoku J Exp Med. 1991;165:253-60.
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