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Vascular medicine and epigenetics group
(Division of Vascular Medicine and Epigenetics)

Group leader

Hironori Nakagami
Hironori Nakagami, MD, Ph.D
[Professor (Division of Vascular Medicine and Epigenetics)]

Carrier

4/1988-3/1994
MD(3/1994)
Nara Medical University, Nara, Japan
4/1994-3/1996
Resident
Jichi Medical School, Tochigi, Japan
4/1996-5/1997
Senior Associate
Jichi Medical School, Tochigi, Japan
Department of Cardiology (K. Shimada)
6/1997-1/2000
Research fellow
Osaka University Medical School, Japan
Department of Geriatric Medicine (T. Ogihara)
10/1998-1/2000
Research fellow
Osaka University Medical School, Japan
Division of Gene Therapy Science (Y. Kaneda)
2/2000-6/2001
Assistant Professor
Ehime University School of Medicine, Japan
Department of Medical Biochemistry (M. Horiuchi)
7/2001-3/2003
Research fellow
Brigham & Women’s Hospital, Harvard Medical School
Vascular Medicine Research (James K. Liao)
4/2003-9/2003
Senior Research Associate
Osaka University Hospital
Medical Center for translational research
10/2003-3/2010
Assistant Professor
Osaka University Graduate School of Medicine, Osaka, Japan
Division of Gene Therapy Science (Y. Kaneda)
4/2010-
Professor
Osaka University, United Graduate School of Child Development, Osaka University, Kanazawa University and Hamamatsu University School of Medicine, Department of Child Development, Division of Vascular Medicine and Epigenetics
Honors
7/2001-3/2003 Merck-Banyu Fellowship Awards in cardiovascular medicine
11/2003 Young Investigator Award in Japanese Society of cardiovascular endocrinology
10/2005 Young Inverstigator Award in Japanese Society of vascular medicine
2/2006 Young Investigator Awards in Japanese Society for Circulation Research
3/2006 Yagi Award in Japanese Society of Circulation
3/2007 Young Investigator Awards in Japanese Society of Circulation
4/2008 Okamoto Awards in Japanese SHR meeting.
4/2008 Biobusiness compe Japan Awards

Editorial board

THE OPEN GENE THERAPY(2007~), THE OPEN NANOMEDICINE JOURNAL(2008~), THE OPEN HYPERTENSION(2008~), Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry(2009~)

Professional Societies

Fellow: Japanese Society of Vascular Biology, Japanese society of Gene Therapy, Japansese Society of Anti-Aging
Member: Japanese Society of Internal Medicine, Japanese Society of Circulation, Japanese Society of Hypertension, Japanese Society of Geriatric Medicine, Japanese Society of Cardiovascular Endocrinology, Japanese Society of Cancer

On going project

  1. DNA vaccine for hypertension, diabetes and dyslipidemia
  2. Translational research of novel antimicrobial peptides
  3. Vascular Biology (anti-angiogenesis and vascular calcification)

BIBLIOGRAPHY (Selected 5 recent papers from 84 original articles)

  1. Shimizu H, Nakagami H, Osako MK, Hanayama R, Kunugiza Y, Kizawa T, Tomita T, Yoshikawa H, Ogihara T, Morishita R. Angiotensin II accelerates osteoporosis by activating osteoclasts. FASEB J. 2008 Jul;22(7):2465-75.
  2. Mori M, Nakagami H, Koibuchi N, Miura K, Takami Y, Koriyama H, Hayashi H, Sabe H, Mochizuki N, Morishita R, Kaneda Y. Zyxin Mediates Actin Fiber Reorganization in Epithelial-Mesenchymal Transition and Contributes to Endocardial Morphogenesis. Mol Biol Cell 2009 Jul;20(13):3115-24.
  3. Kim MS, Lee CS, Hur J, Cho HJ, Jun SI, Kim TY, Lee SW, Suh JW, Park KW, Lee HY, Kang HJ, Lee DS, Koh GY, Nakagami H, Morishita R, Park YB, Kim HS. Priming With Angiopoietin-1 Augments the Vasculogenic Potential of the Peripheral Blood Stem Cells Mobilized With Granulocyte Colony-Stimulating Factor Through a Novel Tie2/Ets-1 Pathway. Circulation. 2009 Dec 1;120(22):2240-50.
  4. Osako MK, Nakagami H, Koibuchi N, Shimizu H, Nakagami F, Koriyama H, Shimamura M, Miyake T, Rakugi H, Morishita R. Estrogen Inhibits Vascular Calcification via Vascular RANKL System. Common Mechanism of Osteoporosis and Vascular Calcification. Circ Res. 2010 Aug 20;107(4):466-75.
  5. Nakagami H, Nishikawa T, Tamura N, Maeda A, Hibino H, Mochizuki M, Shimosato T, Moriya T, Morishita R, Tamai K, Tomono K, Kaneda Y. Modification of a Novel Angiogenic Peptide, AG30, for the Development of Novel Therapeutic Agents. J Cell Mel Med 2011.
[Vascular medicine and epigenetics group]
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