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Alzheimer disease research group
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Publications

Original Articles

  1. Naoyuki Sato. Abeta is prerequisite, but insufficient to cause tau phosphorylation in vivo: tau phosphorylation in APP mice by diabetes. Molecular Neurodegeneration. 2013, 8(Suppl 1):P35 (13 September 2013)
  2. Shimamura, M., Sato, N., Nakagami, H., Osako, M.K., Kyutoku, M., Wakayama, K., Morishita, R. Chronic deposition of Aβ influences microcirculation in the chronic stage of cerebral Ischemia. Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry, 13(1), pp.77-80
  3. Shuko Takeda,Naoyuki Sato, Kazuko Ikimura, Hirohito Nishino, Hiromi Rakugi and Ryuichi Morishita. Increased Blood-Brain Barrier Vulnerability to Systemic Inflammation in Alzheimer Disease Mouse Model. Neurobiology of Aging, 2013, in press
  4. Naoyuki Sato, Ryuichi Morishita. Plasma Abeta: A Possible Missing Link Between Alzheimer Disease and Diabetes. DIABETES, 62, 1005-1006, 2013
  5. Naoyuki Sato, Masayasu Okochi, Mitsuru Shinohara, Gopal Thinakaran, Shuko Takeda, Akio Fukumori, Motoko Shinohara-Noma, Mari Mori-Ueda, Hizuki Hamada, Masatoshi Takeda, Hiromi Rakugi, Ryuichi Morishita. Differential Regulation of Amyloid Precursor Protein /Presenilin 1 Interaction during Aβ40/42 Production Detected Using Fusion Constructs. PLoS ONE 2012;7(11): e48551. doi:10.1371/journal.pone.0048551
  6. Shuko Takeda, Naoyuki Sato, Kozue Uchio-Yamada, Hisahiro Yu, Atsushi Moriguchi, Hiromi Rakugi, and Ryuichi Morishita. Oral Glucose Loading Modulates Plasma β-Amyloid Level in Alzheimer's Disease Patients: Potential Diagnostic Method for Alzheimer's Disease. Dementia and Geriatric Cognitive Disorders, 2012;34(1):25-30.
  7. Shimamura M, Sato N, Nakagami H, Taniyama Y, Morishita R. Development of nucleic Acid drugs for neurological disorders. Curr Top Med Chem. 2012 Aug 1;12(15):1621-9.
  8. Hayashi H, Nakagami H, Takeichi M, Shimamura M, Koibuchi N, Oiki E, Sato N, Koriyama H, Mori M, Gerardo Araujo R, Maeda A, Morishita R, Tamai K, Kaneda Y. HIG1, a novel regulator of mitochondrial γ-secretase, maintains normal mitochondrial function. FASEB J. 2012 Jun;26(6):2306-17.
  9. Shimamura M, Taniyama Y, Katsuragi N, Koibuchi N, Kyutoku M, Sato N, Allahtavakoli M, Wakayama K, Nakagami H, Morishita R. Role of Central Nervous System Periostin in Cerebral Ischemia. Stroke. 2012 Apr;43(4):1108-14.
  10. Naoyuki Sato, Mitsuru Shinohara, Hiromi Rakugi, Ryuichi Morishita. Dual effects of statins on Abeta metabolism: Up-regulation of degradation of APP-CTF and Abeta clearance. Neurodegenerative diseases, 2012;10(1-4):305-8.
  11. Shimamura M, Sato N, Morishita R. Experimental and clinical application of plasmid DNA in the field of central nervous diseases. Curr Gene Ther., 2011 Dec;11(6):491-500.
  12. Shuko Takeda, Naoyuki Sato, Kazuko Ikimura, Hirohito Nishino, Hiromi Rakugi and Ryuichi Morishita. Novel microdialysis method to assess neuropeptides and large molecules in free-moving mouse. Neuroscience, 2011 Jul 14;186:110-9.
  13. Takeda S, Sato N, Rakugi H, Morishita R. Molecular mechanisms linking diabetes mellitus and Alzheimer disease: beta-amyloid peptide, insulin signaling, and neuronal function. Mol Biosyst. 2011 Jun;7(6):1822-7.
  14. Sato N, Takeda S, Uchio-Yamada K, Ueda H, Fujisawa T, Rakugi H, Morishita R. Role of Insulin Signaling in the Interaction Between Alzheimer Disease and Diabetes Mellitus: A Missing Link to Therapeutic Potential. Curr Aging Sci. 2011 Jul;4(2):118-27.
  15. Mitsuru Shinohara, Naoyuki Sato, Hitomi Kurinami, Daisuke Takeuchi, Shuko Takeda, Munehisa Shimamura, Toshihide Yamashita, Yasuo Uchiyama, Hiromi Rakugi, and Ryuichi Morishita. Reduction of brain Aβ by fluvastatin, an HMG-CoA reductase inhibitor, through increase in degradation of APP-CTFs and Aβ clearance. The Journal of Biological Chemistry 2010 Jul 16;285(29):22091-102.
  16. Shuko Takeda, Naoyuki Sato, Hiromi Rakugi, and Ryuichi Morishita. Plasma Beta-Amyloid as Potential Biomarker of Alzheimer Disease: Possibility of Diagnostic Tool of Alzheimer Disease. Molecular BioSystems, 2010 Oct;6(10):1760-6.
  17. Shuko Takeda, Naoyuki Sato, Kozue Uchio-Yamada, Kyoko Sawada, Takanori Kunieda, Daisuke Takeuchi, Hitomi Kurinami, Mitsuru Shinohara, Hiromi Rakugi, and Ryuichi Morishita. Diabetes accelerated memory dysfunction via cerebrovascular inflammation and Aβ deposition in an Alzheimer mouse model with diabetes. Proc Natl Acad Sci U S A (PNAS), 2010 Apr 13;107(15):7036-41.
  18. Shuko Takeda, Naoyuki Sato, Daisuke Takeuchi, Hitomi Kurinami, Mitsuru Shinohara, Kazue Niisato, Masanobu Kano, Toshio Ogihara, Hiromi Rakugi, and Ryuichi Morishita. Angiotensin Receptor Blocker Prevented β-Amyloid-Induced Cognitive Impairment Associated with Recovery of Neurovascular Coupling. Hypertension, 2009, 54, 1345-52.
  19. Hayashi S, Sato N, Yamamoto A, Ikegame Y, Nakashima S, Ogihara T, Morishita R. Alzheimer disease-associated peptide, amyloid beta40, inhibits vascular regeneration with induction of endothelial autophagy. Arterioscler Thromb Vasc Biol. 2009, 29, 1909-15.
  20. Fournier A, Oprisiu-Fournier R, Serot JM, Godefroy O, Achard JM, Faure S, Mazouz H, Temmar M, Albu A, Bordet R, Hanon O, Gueyffier F, Wang J, Black S, Sato N. Prevention of dementia by antihypertensive drugs: how AT1-receptor-blockers and dihydropyridines better prevent dementia in hypertensive patients than thiazides and ACE-inhibitors. Expert Rev Neurother. 2009, Sep;9(9):1413-31.
  21. Shuko Takeda, Naoyuki Sato, Kazue Niisato, Daisuke Takeuchi, Hitomi Kurinami, Mituru Shinohara, Hiromi Rakugi, Masanobu Kano, and Ryuichi Morishita. Validation of Aβ1-40 Administration into Mouse Cerebroventricles as an Animal Model for Alzheimer Disease. Brain Research, 1280, pp137-147, 2009.
  22. Shuko Takeda, Naoyuki Sato, Kozue Uchio-Yamada, Kyoko Sawada, Takanori Kunieda, Daisuke Takeuchi, Hitomi Kurinami, Mitsuru Shinohara, Hiromi Rakugi, and Ryuichi Morishita. Elevation of Plasma β-amyloid Level by Glucose Loading in Alzheimer Mouse Models. Biochemical and Biophysical Research Communications, 385, pp193-197, 2009.
  23. Wakayama K, Shimamura M, Sata M, Koibuchi N, Sato N, Ogihara T, Morishita R. A model of cerebrovascular injury in rats. J Neurosci Methods. 2008, 175, 187-95.
  24. Kurinami H, Sato N, Shinohara M ,Takeuchi D, Takeda S, Shimamura M, Ogihara T and Morishita R. Prevention of amyloid beta-induced memory impairment by fluvastatin, associated with the decrease in amyloid beta accumulation and oxidative stress in amyloid beta injection mouse model. International Journal of Molecular Medicine 2008, 21, 531-7.
  25. Takeuchi D, Sato N, Shimamura M, Kurinami H, Takeda S , Shinohara M , Suzuki S , Kojima M, Ogihara T and Morishita R. Alleviation of Abeta-induced cognitive impairment by ultrasound-mediated gene transfer of HGF in a mouse model. Gene Therapy, 2008, 15, 561-71.
  26. Takeda S, Sato N, Ogihara T, Morishita R. The Renin-Angiotensin System, Hypertension and cognitive dysfunction in Alzheimer's Disease: New Therapeutic Potential. Frontiers in Bioscience. 2008, 13, 2253-65.
  27. Hayashi H, Nakagami H, Takami Y, Sato N, Saitoh Y, Nishikawa T, Mori M, Koriyama H, Tamai K, Morishita R, Kaneda Y. Involvement of gamma-secretase in postnatal angiogenesis. Biochem. Biophys. Res. Commun. 2007, 363, 584-90.
  28. Shimamura M, Sato N, Sata, M, Kurinami H, Takeuchi D, Wakayama K, Hayashi T, Iida H, Morishita R. Delayed Post-ischemic Treatment with Fluvastatin Improved Learning and Memory Deficit After Stroke in Rats. Stroke 2007, 38, 3251-8.
  29. Shimamura M, Sato N, Sata M, Wakayama K, Ogihara T, Morishita R. Expression of hepatocyte growth factor and c-Met after spinal cord injury in rats. Brain Res. 2007.
  30. Wakayama K, Shimamura M, Sata M, Sato N, Kawakami K, Fukuda H, Tomimatsu T, Ogihara T, Morishita R. Quantitative measurement of neurological deficit after mild (30 min) transient middle cerebral artery occlusion in rats. Brain Res. 2007, 1130, 181-7.
  31. Shimamura, M., Sato, N., Yoshimura S, Kaneda, Y., Morishita, R. HVJ-based non-viral gene transfer method: successful gene therapy using HGF and VEGF genes in experimental ischemia Frontiers in Bioscience. (2006)11, 753-759.
  32. Sato N, Shimamura M, Takeuchi D, Kurinami H, Ogihara T, Morishita R. Gene Therapy for Ischemic Brain Disease with special reference to Vascular Dementia. Geriatrics and Gerontology International. (2006).
  33. Shimamura M, Sato N, Waguri S, Uchiyama Y, Hayashi T, Iida H, Nakamura T, Ogihara T, Kaneda Y, Morishita M. Gene Transfer of Hepatocyte Growth Factor Gene Improves Learning and Memory in the Chronic Stage of Cerebral Infarction. Hypertension. 47, 742-51 (2006).
  34. Sato N, Okochi M, Taniyama Y, Kurinami H, Shimamura M, Takeuchi D, Hamada H, Fukumori A, Kiyosue K, Taguchi T, Tanaka T, Miyasaka M, Takeda M, Ogihara T, Morishita R. Development of new screening system for Alzheimer Disease, in vitro Abeta sink assay, to identify the dissociation of soluble Abeta from fibrils. Neuobiology of Disease. (2006).
  35. Sato N, Shimamura M, Morishita R. Recent Progress in Cerebrovascular Gene Therapy. Current Neurovascular Research. 2, 235-247(2005).
  36. Shimamura, M., Sato, N., Taniyama, Y., Kurinami, H., Tanaka, H., Takami, T., Ogihara, T., Tohyama, M., Kaneda, Y. & Morishita, R. Gene transfer into adult rat spinal cord using naked plasmid DNA and ultrasound microbubbles. J. Gene Med. (2005).
  37. Shimamura M, Sato N, Taniyama Y, Yamamoto S, Endoh M, Kurinami H, Aoki M, Ogihara T, Kaneda Y, Morishita R. Development of efficient plasmid DNA transfer into adult rat central nervous system using microbubble-enhanced ultrasound. Gene Ther. 11:1532-9, 2004.
  38. Shimamura M, Sato N, Oshima K, Aoki M, Kurinami H, Waguri S, Uchiyama Y, Ogihara T, Kaneda Y, Morishita R. Novel therapeutic strategy to treat brain ischemia: overexpression of hepatocyte growth factor gene reduced ischemic injury without cerebral edema in rat model. Circulation, 109:424-31, 2004.
  39. Thinakaran G, Bowen JW, Ito D, Leem JY, Veselits ML, Sato N. Investigation of unfolded-protein response in cells expressing familial Alzheimer's disease-linked presenilin variants. Methods Mol Biol. 232, 203-16, 2003.
  40. Suzuki T, Fukuo K, Suhara T, Yasuda O, Sato N, Takemura Y, Tsubakimoto M, Ogihara T. Eicosapentaenoic acid protects endothelial cells against anoikis through restoration of cFLIP. Hypertension. 2003, 42, 342-8.
  41. Fukuo K, Yang J, Suzuki T, Kaimoto T, Takemura Y, Yasuda O, Suhara T, Sato N, Ogihara T. Nifedipine upregulates manganese superoxide dismutase expression in vascular smooth muscle cells via endothelial cell-dependent pathways. Hypertens Res. 2003, 26, 503-8.
  42. Mori M, Nakagami H, Morishita R, Mitsuda N, Yamamoto K, Yoshimura S, Ohkubo N, Sato N, Ogihara T, Kaneda Y. N141I mutant presenilin-2 gene enhances neuronal cell death and decreases bcl-2 expression. Life Sci. 2002 70:2567-80.
  43. Fukuo K, Yang J, Yasuda O, Mogi M, Suhara T, Sato N, Suzuki T, Morimoto S, Ogihara T. Nifedipine Indirectly Upregulates Superoxide Dismutase Expression in Endothelial Cells via Vascular Smooth Muscle Cell-Dependent Pathways. Circulation. 2002, 106, 356-61.
  44. Mitsuda N, Ohkubo N, Tamatani M, Lee YD, Taniguchi M, Namikawa K, Kiyama H, Yamaguchi A, Sato N, Sakata K, Ogihara T, Vitek MP, Tohyama M. Activated cyclic AMP- response element-binding protein regulates neuronal expression of presenilin-1. J Biol Chem. 2001 276:9688-98.
  45. Sato N, Urano F, Yoon Leem J, Kim SH, Li M, Donoviel D, Bernstein A, Lee AS, Ron D, Veselits ML, Sisodia SS, Thinakaran G. Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression. Nat Cell Biol. 2000, 2, 863-70.
  46. Hatanaka Y, Kamino K, Fukuo K, Mitsuda N, Nishiwaki-Ueda Y, Sato N, Satoh T, Yamamoto H, Yoneda H, Imagawa M, Miki T, Ohta S, Ogihara T. Low density lipoprotein receptor-related protein gene polymorphisms and risk for late-onset Alzheimer's disease in a Japanese population. Clin Genet. 2000 58: 319-23.
  47. Sato N, Kamino K, Tateishi K, Satoh T, Nishiwaki Y, Yoshiiwa A, Miki T, Ogihara T. Elevated Amyloid beta Protein(1-40) Level Induces CREB Phosphorylation at serine-133 via p44/p42 MAP Kinase(ERK1/2)-dependent Pathway in Rat Pheochromocytoma PC12 Cells. Biochem. Biophys. Res. Commun., 1997, 232, 637-642.
  48. Nishiwaki Y, Kamino K, Yoshiiwa A, Sato N, Tateishi K, Takeda M, Kobayashi T, Yamamoto H, Nonomura Y, Yoneda H, Sakai T, Imagawa M, Miki T, Ogihara T. T/G polymorphism at intron 9 of presenilin 1 gene is associated with, but not responsible for sporadic late-onset Alzheimer's disease in Japanese population. Neurosci Lett., 1997, 227, 123-6.
  49. Yoshiiwa A, Kamino K, Yamamoto H, Kobayashi T, Imagawa M, Nonomura Y, Yoneda H, Sakai T, Nishiwaki Y, Sato N, Rakugi H, Miki T, Ogihara T. alpha 1-Antichymotrypsin as a risk modifier for late-onset Alzheimer's disease in Japanese Apolipoprotein E epsilon 4 allele carriers. Annals of Neurology, 1997, 42, 115-117.
  50. Miki T, Nakura J, Ye L, Mitsuda N, Morishima A, Sato N, Kamino K, Ogihara T. Molecular and epidemiological studies of Werner syndrome in the Japanese population. Mech Ageing Dev. 1997, 98, 255-65.
  51. Sato N, Fujio Y, Yamada-Honda Y, Funai H, Wada A, Kawashima S, Awata N, Shibata N. (1995) Elevated calcium level induces calcium-dependent proteolysis of A-CAM (N-cadherin) in heart - analysis by detergent-treated model. Biochem. Biophys. Res. Commun.,217, 649-653.
  52. Fujio Y, Yamada-Honda Y, Sato N, Funai H, Wada A, Awata N, Shibata N. (1995) Disruption of cell-cell adhesion in an inbred strain of hereditary cardiomyopathic hamster (Bio 14.6). Cardiovascular Research, 30, 899-904.

Reviews

  1. Naoyuki Sato and Ryuichi Morishita. The roles of lipid and glucose metabolism in modulation of β-amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer disease.
    Front. Aging Neurosci. Published on 23 Oct 2015, doi:10.3389/fnagi.2015.00199
  2. Naoyuki Sato and Ryuichi Morishita.
    Brain alterations and clinical symptoms of dementia in diabetes: Aβ/tau-dependent and independent mechanisms.
    Frontiers in Endocrinology. Front. Endocrinol. | doi: 10.3389/fendo.2014.00143
  3. Shuko Takeda, Naoyuki Sato and Ryuichi Morishita.
    Systemic inflammation, blood-brain barrier vulnerability and cognitive / non-cognitive symptoms in Alzheimer disease: Relevance to pathogenesis and therapy.
    Front. Aging Neurosci. doi: 10.3389/fnagi.2014.00171.
  4. Mitsuru Shinohara, Naoyuki Sato, Hitomi Kurinami, Munehisa Shimamura, Toshimitsu Hamasaki, Amarnath Chatterjee, Hiromi Rakugi and Ryuichi Morishita.
    Possible modification of Alzheimer's disease by statins in midlife: interactions with genetic and non-genetic risk factors.
    Front. Aging Neurosci. doi: 10.3389/fnagi.2014.00071.
  5. Naoyuki Sato and Ryuichi Morishita.
    Aβ Deposition, Insulin Signaling, and Tau Phosphorylation in Animal Models of Alzheimer Disease and Diabetes.
    Metabolic Syndrome and Neurological Disorders. Eds: Akhlaq A. Farooqui , Tahira Farooqui. John Wiley & Sons, Inc.383-394. 2013.
  6. Sato N and Morishita R.
    Roles of Vascular and Metabolic Components in Cognitive Dysfunction of Alzheimer disease: Short- and Long-term Modification by Non-genetic Risk Factors.
    Front. Aging Neurosci. 5:64. doi: 10.3389/fnagi.2013.00064, 2013.
  7. Naoyuki Sato
    Molecular Mechanisms Linking Alzheimer's Disease And Its Non-Genetic Risk Factors - Towards Novel Therapeutic Strategies.
    Pathological interaction between Alzheimer's disease and diabetes mellitus
    The Journal of Nutrition, Health & Aging. Volume 17, Supplement 1, S136, 2013.
  8. Shuko Takeda, Naoyuki Sato, Hiromi Rakugi, Ryuichi Morishita
    Animal Models of Alzheimer Disease for Translational Research: Current and Future Concepts
    Horizons in Neuroscience Research. Volume 4 (Hardcover), Nova Science Publishers, Inc., ISBN: 978-1-61728-929-3 (Pub. Date: 2010 4th quarter)
  9. Sato N and Thinakaran G.
    The Unfolded Protein Response-mediated Upregulation of BiP and CHOP Is not Affected by Presenilin Expression.
    Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics
    [Edited by Khalid Iqbal, Sangram S. Sisodia and Bengt Winblad](John Wiley & Sons Ltd): pp559-568, 2001
  10. Kamino K, Yoshiiwa A, Nishiwaki Y, Sato N, Tateishi K, Kudo T, Nishimura T, Takeda M, Miki T and Ogihara T.
    Integration of genetic factors into pathogenesis of Alzheimer's disease.
    Research and Practice in Alzheimer's disease.
    [eds. Vellas B. et al](Springer Publishing Company, Paris.) : pp51-70, 1998
  11. Sato N, Kamino K, Tateishi K, Satoh T, Nishiwaki Y, Yoshiiwa A, Miki T, Ogihara T.
    Differential effects on CREB Phosphorylation at serine-133 between Amyloid beta Protein(1-40) and Amyloid beta Protein(1-42) at the concentrations of μM.
    Yakura, H. (Ed.) Kinases and Phosphatases in Lymphocyte and Neuronal Signaling, 1997, 301-302.
  Leader Members Publications
[Alzheimer disease research group]
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