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Nucleic acid medicine group

Publications

Original articles

  1. Nakashima H, Aoki M, Miyake T, Kawasaki T, Iwai M, Jo N, Oishi M, Kataoka K, Ohgi S, Ogihara T, Kaneda Y, Morishita R. Inhibition of experimental abdominal aortic aneurysm in the rat by use of decoy oligodeoxynucleotides suppressing activity of nuclear factor kappaB and ets transcription factors. Circulation. 2004;109:132-138.
  2. Kanazawa S, Miyake T, Kakinuma T, Tanemoto K, Tsunoda T, Kikuchi K. The expression of platelet-derived growth factor and connective tissue growth factor in different types of abdominal aortic aneurysms. J Cardiovasc Surg (Torino). 2005;46:271-278.
  3. Miwa K, Nakashima H, Aoki M, Miyake T, Kawasaki T, Iwai M, Oishi M, Kataoka K, Ohgi S, Ogihara T, Kaneda Y, Morishita R.Inhibition of ets, an essential transcription factor for angiogenesis, to prevent the development of abdominal aortic aneurysm in a rat model. Gene Ther. 2005;12:1109-1118.
  4. Miyake T, Aoki M, Nakashima H, Kawasaki T, Oishi M, Kataoka K, Tanemoto K, Ogihara T, Kaneda Y, Morishita R. Prevention of abdominal aortic aneurysms by simultaneous inhibition of NFkappaB and ets using chimeric decoy oligonucleotides in a rabbit model. Gene Ther. 2006;13:695-704.
  5. Miyake T, Aoki M, Shiraya S, Tanemoto K, Ogihara T, Kaneda Y, Morishita R. Inhibitory effects of NFkappaB decoy oligodeoxynucleotides on neointimal hyperplasia in a rabbit vein graft model. J Mol Cell Cardiol. 2006;41:431-440.
  6. Shiraya S, Miwa K, Aoki M, Miyake T, Oishi M, Kataoka K, Ohgi S, Ogihara T, Kaneda Y, Morishita R. Hypertension accelerated experimental abdominal aortic aneurysm through upregulation of nuclear factor kappaB and Ets. Hypertension. 2006;48:628-636.
  7. Miyake T, Aoki M, Masaki H, Kawasaki T, Oishi M, Kataoka K, Ogihara T, Kaneda Y, Morishita R. Regression of Abdominal Aortic Aneurysms by Simultaneous Inhibition of Nuclear Factor {kappa}B and Ets in a Rabbit Model. Circ Res. 2007;101,1175-1184.
  8. Nakagawa A, Makino H, Aoki M, Miyake T, Shiraya S, Nakamura T, Ogihara T, Kimata Y, Morishita R. Improvement of survival of skin flaps by combined gene transfer of hepatocyte growth factor and prostacyclin synthase. J Gene Med. 2007;9:1087-1094.
  9. Shiraya S, Miyake T, Aoki M, Yoshikazu F, Ohgi S, Nishimura M, Ogihara T, Morishita R. Inhibition of development of experimental aortic abdominal aneurysm in rat model by atorvastatin through inhibition of macrophage migration. Atherosclerosis. 2009;202:34-40.
  10. Miyake T, Aoki M, Morishita R. Inhibition of Anastomotic Intimal Hyperplasia Using a Chimeric Decoy Strategy Against NF{kappa}B and E2F in a Rabbit Model. Cardiovasc Res. 2008;79:706-714.
  11. Fujiwara Y, Shiraya S, Miyake T, Yamakawa S, Aoki M, Makino H, Nishimura M, Morishita R. Inhibition of experimental abdominal aortic aneurysm in a rat model by the angiotensin receptor blocker valsartan. Int J Mol Med. 2008;22:703-708.
  12. Aoki T, Nishimura M, Kataoka H, Ishibashi R, Miyake T, Takagi Y, Morishita R, Hashimoto N. Role of angiotensin II type 1 receptor in cerebral aneurysm formation in rats. Int J Mol Med. 2009;24:353-359.
  13. Osako MK, Nakagami H, Koibuchi N, Shimizu H, Nakagami F, Koriyama H, Shimamura M, Miyake T, Rakugi H, Morishita R. Estrogen inhibits vascular calcification via vascular RANKL system: common mechanism of osteoporosis and vascular calcification. Circ Res. 2010;107:466-475.
  14. Nakagami H, Kiomy Osako M, Nakagami F, Shimosato T, Minobe N, Moritani T, Shimamura M, Miyake T, Shimizu H, Takeya Y, Morishita R. Prevention and regression of non-alcoholic steatohepatitis (NASH) in a rat model by metabosartan, telmisartan. Int J Mol Med. 2010;26:477-481.
  15. Miyake T, Aoki M, Osako MK, Shimamura M, Nakagami H, Morishita R. Systemic Administration of Ribbon-type Decoy Oligodeoxynucleotide Against Nuclear Factor κB and Ets Prevents Abdominal Aortic Aneurysm in Rat Model. Mol Ther. 2011;19:181-187.
  16. Miyake T, Aoki M, Osako MK, Shimamura M, Nakagami H, Morishita R. Systemic Administration of Ribbon-type Decoy Oligodeoxynucleotide Against Nuclear Factor κB and Ets Prevents Abdominal Aortic Aneurysm in Rat Model. Mol Ther. 2011;19:181-187.
  17. Nakagami H, Shimamura M, Miyake T, Shimosato T, Minobe N, Moritani T, Kiomy Osako M, Nakagami F, Koriyama H, Kyutoku M, Shimizu H, Katsuya T, Morishita R. Nifedipine prevents hepatic fibrosis in a non-alcoholic steatohepatitis model induced by an L-methionine-and choline-deficient diet. Mol Med Report. 2012;5:37-40.

Reviews

  1. Miyake T, Morishita R. Pharmacological treatment of abdominal aortic aneurysm. Cardiovasc Res. 2009;83:436-443.

Book

  1. Miyake T, Morishita R. Gene therapy for angiogenesis and restenosis. Coronary stent restenosis. Edited by Tintoiu IC et.al. The publishing House of the Romanian academy. Romania, 2011.755-767.
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