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Groups

Specially appointed researchers group

Leader

Publications

Group leader

Motokuni
Aoki

Tomohiro
Katsuya

Naoyuki
Sato

Yoshiaki
Taniyama

Naotaka
Hashiya

Sawako
Hibino

Shin-ichiro
Hayashi

Naoyuki Sato, M.D., Ph.D.

Professional Carrier

1992: Osaka University Hospital, redident
1993-1995: Osaka Medical Center for Cancer and Cardiovascular Diseases, redident
1995-1999: Osaka University, Graduate School of Medicine, graduate student
1999: Japan Society for Promotion of Science, postdoctral fellow
1999-2001: University of Chicago, Visitting Scientist
2001: University of Chicago, Research Associate
2002: Osaka University, Graduate School of Medicine, Assisitant Professor
2007: Osaka University, Graduate School of Medicine, Associate Professor

Education

1992	Osaka University, Medical School
1999	Osaka University, Graduate School of Medicine

License

1992	Medical doctor
2008	Board Certified Member of the Japanese Society of Internal Medicine

Society

The Japanese society of internal medicine, The Japanese society of geriatric medicine, The Japanese society of dementia, The Japanese circulation Society, Japan Diabetes Society, The Society of cardiovascular endocrinology and metabolism, Society for Neuroscience, The Alzheimer's Association International Society to Advance Alzheimer Research and Treatment

Awards and Honors

2002	Novartis foundation for gerontological research award
2002	Chiyoda foundation for medical research award
2003	Kanae foundation for the promotion of medical science award
2011	Takeda Science Foundation "Role of insulin signaling in the interaction between diabetes mellitus and Alzheimer disease"

Pubications

Original Articles

Fujio Y, Yamada-Honda Y, Sato N, Funai H, Wada A, Awata N, Shibata N. Disruption of cell-cell adhesion in an inbred strain of hereditary cardiomyopathic hamster (Bio 14.6). Cardiovascular Research, 30, 899-904, 1995.
Sato N, Fujio Y, Yamada-Honda Y, Funai H, Wada A, Kawashima S, Awata N, Shibata N. Elevated calcium level induces calcium-dependent proteolysis of A-CAM (N-cadherin) in heart - analysis by detergent-treated model. Biochem. Biophys. Res. Commun., 217, 649-653, 1995.
Yoshiiwa A, Kamino K, Yamamoto H, Kobayashi T, Imagawa M, Nonomura Y, Yoneda H, Sakai T, Nishiwaki Y, Sato N, Rakugi H, Miki T, Ogihara T. α1- Antichymotrypsin as a risk modifier for late-onset Alzheimer's disease in Japanese Apolipoprotein Eε4 allele carriers. Annals of Neurology, 42, 115-117, 1997.
Nishiwaki Y, Kamino K, Yoshiiwa A, Sato N, Tateishi K, Takeda M, Kobayashi T, Yamamoto H, Nonomura Y, Yoneda H, Sakai T, Imagawa M, Miki T, Ogihara T. T/G polymorphism at intron 9 of presenilin 1 gene is associated with, but not responsible for sporadic late-onset Alzheimer's disease in Japanese population. Neurosci Lett., 227, 123-6, 1997.
Sato N, Kamino K, Tateishi K, Satoh T, Nishiwaki Y, Yoshiiwa A, Miki T, Ogihara T. Elevated Amyloid β Protein(1-40) Level Induces CREB Phosphorylation at serine-133 via p44/p42 MAP Kinase(ERK1/2)-dependent Pathway in Rat Pheochromocytoma PC12 Cells. Biochem. Biophys. Res. Commun. 232, 637-642, 1997.
Mitsuda N, Ohkubo N, Tamatani M, Lee YD, Taniguchi M, Namikawa K, Kiyama H, Yamaguchi A, Sato N, Sakata K, Ogihara T, Vitek MP, Tohyama M. Activated cyclic AMP- response element-binding protein regulates neuronal expression of presenilin-1. J Biol Chem. 276:9688-98, 2001.
Hatanaka Y, Kamino K, Fukuo K, Mitsuda N, Nishiwaki-Ueda Y, Sato N, Satoh T, Yamamoto H, Yoneda H, Imagawa M, Miki T, Ohta S, Ogihara T. Low density lipoprotein receptor-related protein gene polymorphisms and risk for late-onset Alzheimer's disease in a Japanese population. Clin Genet. 58：319-23, 2000.
Sato N, Urano F, Yoon Leem J, Kim SH, Li M, Donoviel D, Bernstein A, Lee AS, Ron D, Veselits ML, Sisodia SS, Thinakaran G. Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression. Nat Cell Biol. 2, 863-70, 2000.
Mori M, Nakagami H, Morishita R, Mitsuda N, Yamamoto K, Yoshimura S, Ohkubo N, Sato N, Ogihara T, Kaneda Y. N141I mutant presenilin-2 gene enhances neuronal cell death and decreases bcl-2 expression. Life Sci. 70:2567-80, 2002.
Fukuo K, Yang J, Yasuda O, Mogi M, Suhara T, Sato N, Suzuki T, Morimoto S, Ogihara T. Nifedipine Indirectly Upregulates Superoxide Dismutase Expression in Endothelial Cells via Vascular Smooth Muscle Cell-Dependent Pathways. Circulation. 106, 356-61, 2002.
Fukuo K, Yang J, Suzuki T, Kaimoto T, Takemura Y, Yasuda O, Suhara T, Sato N, Ogihara T. Nifedipine upregulates manganese superoxide dismutase expression in vascular smooth muscle cells via endothelial cell-dependent pathways. Hypertens Res. 26, 503-8, 2003.
Suzuki T, Fukuo K, Suhara T, Yasuda O, Sato N, Takemura Y, Tsubakimoto M, Ogihara T. Eicosapentaenoic acid protects endothelial cells against anoikis through restoration of cFLIP. Hypertension. 42, 342-8, 2003.
Shimamura M, Sato N, Oshima K, Aoki M, Kurinami H, Waguri S, Uchiyama Y, Ogihara T, Kaneda Y, Morishita R. A novel therapeutic strategy to treat brain ischemia: Over-expression of hepatocyte growth factor gene reduced ischemic injury without cerebral edema in rat model. Circulation, 109:424-31, 2004.
Shimamura M, Sato N, Taniyama Y, Yamamoto S, Endoh M, Kurinami H, Aoki M, Ogihara T, Kaneda Y, Morishita R. Development of efficient plasmid DNA transfer into adult rat central nervous system using microbubble-enhanced ultrasound. Gene Ther. 11:1532-9, 2004.
Shimamura, M., Sato, N., Taniyama, Y., Kurinami, H., Tanaka, H., Takami, T., Ogihara, T., Tohyama, M., Kaneda, Y. & Morishita, R. Gene transfer into adult rat spinal cord using naked plasmid DNA and ultrasound microbubbles. J. Gene Med. (2005).
Sato N, Okochi M, Taniyama Y, Kurinami H, Shimamura M, Takeuchi D, Hamada H, Fukumori A, Kiyosue K, Taguchi T, Tanaka T, Miyasaka M, Takeda M, Ogihara T, Morishita R. Development of new screening system for Alzheimer Disease, in vitro Aβ sink assay, to identify the dissociation of soluble Aβ from fibrils. Neuobiology of Disease 22, 487-495, 2006.
Shimamura M, Sato N, Waguri S, Uchiyama Y, Hayashi T, Iida H, Nakamura T, Ogihara T, Kaneda Y, Morishita R. Gene Transfer of Hepatocyte Growth Factor Gene Improves Learning and Memory in the Chronic Stage of Cerebral Infarction. Hypertension. 47, 742-51 ,2006.
Wakayama K, Shimamura M, Sata M, Sato N, Kawakami K, Fukuda H, Tomimatsu T, Ogihara T, Morishita R. Quantitative measurement of neurological deficit after mild (30 min) transient middle cerebral artery occlusion in rats. Brain Res. 1130, 181-7, 2007.
Shimamura M, Sato N, Sata M, Wakayama K, Ogihara T, Morishita R. Expression of hepatocyte growth factor and c-Met after spinal cord injury in rats. Brain Res. 2007, 1151, 188-94.
Shimamura M, Sato N, Sata, M, Kurinami, H, Takeuchi, D, Wakayama, K, Hayashi, T, Iida, H, Morishita R. Delayed Post-ischemic Treatment with Fluvastatin Improved Learning and Memory Deficit After Stroke in Rats. Stroke 38, 3251-8, 2007.
Hayashi H, Nakagami H, Takami Y, Sato N, Saitoh Y, Nishikawa T, Mori M, Koriyama H, Tamai K, Morishita R, Kaneda Y. Involvement of gamma-secretase in postnatal angiogenesis. Biochem. Biophys. Res. Commun. 363, 584-90, 2007.
Takeuchi D, Sato N, Shimamura M, Kurinami H, Takeda S , Shinohara M , Suzuki S , Kojima M, Ogihara T and Morishita R. Alleviation of Aβ-induced cognitive impairment by ultrasound-mediated gene transfer of HGF in a mouse model. Gene Therapy, 15, 561-71, 2008.
Kurinami H, Sato N, Shinohara M ,Takeuchi D, Takeda S, Shimamura M, Ogihara T and Morishita R. Prevention of amyloid β-induced memory impairment by fluvastatin, associated with the decrease in amyloid β accumulation and oxidative stress in amyloid β injection mouse model. International Journal of Molecular Medicine 21, 531-7, 2008.
Wakayama K, Shimamura M, Sata M, Koibuchi N, Sato N, Ogihara T, Morishita R. A model of cerebrovascular injury in rats. J Neurosci Methods. 175, 187-95, 2008.
Shuko Takeda, Naoyuki Sato, Kozue Uchio-Yamada, Kyoko Sawada, Takanori Kunieda, Daisuke Takeuchi, Hitomi Kurinami, Mitsuru Shinohara, Hiromi Rakugi, and Ryuichi Morishita. Elevation of Plasma β-amyloid Level by Glucose Loading in Alzheimer Mouse Models. Biochemical and Biophysical Research Communications, 385, 193-197, 2009.
Shuko Takeda, Naoyuki Sato, Kazue Niisato, Daisuke Takeuchi, Hitomi Kurinami, Mituru Shinohara, Hiromi Rakugi, Masanobu Kano, and Ryuichi Morishita. Validation of Aβ1-40 Administration into Mouse Cerebroventricles as an Animal Model for Alzheimer Disease. Brain Research, 1280, pp137-147, 2009.
Hayashi S, Sato N, Yamamoto A, Ikegame Y, Nakashima S, Ogihara T, Morishita R. Alzheimer disease-associated peptide, amyloid beta40, inhibits vascular regeneration with induction of endothelial autophagy. Arterioscler Thromb Vasc Biol. 29, 1909-15, 2009.
Shuko Takeda, Naoyuki Sato, Daisuke Takeuchi, Hitomi Kurinami, Mitsuru Shinohara, Kazue Niisato, Masanobu Kano, Toshio Ogihara, Hiromi Rakugi, and Ryuichi Morishita. Angiotensin Receptor Blocker Prevented β-Amyloid-Induced Cognitive Impairment Associated with Recovery of Neurovascular Coupling. Hypertension, 54, 1345-52, 2009.
Shuko Takeda, Naoyuki Sato, Kozue Uchio-Yamada, Kyoko Sawada, Takanori Kunieda, Daisuke Takeuchi, Hitomi Kurinami, Mitsuru Shinohara, Hiromi Rakugi, and Ryuichi Morishita. Diabetes accelerated memory dysfunction via cerebrovascular inflammation and Aβ deposition in an Alzheimer mouse model with diabetes. Proc Natl Acad Sci U S A, 13, 107, 7036-41, 2010.
Mitsuru Shinohara, Naoyuki Sato, Hitomi Kurinami, Daisuke Takeuchi, Shuko Takeda, Munehisa Shimamura, Toshihide Yamashita, Yasuo Uchiyama, Hiromi Rakugi, and Ryuichi Morishita. Reduction of brain Aβ by fluvastatin, an HMG-CoA reductase inhibitor, through increase in degradation of APP-CTFs and Aβ clearance. The Journal of Biological Chemistry 285, 22091-22102, 2010.
Naoyuki Sato, Shuko Takeda, Kozue Uchio-Yamada, Hironori Ueda, Tomomi Fujisawa, Hiromi Rakugi, Ryuichi Morishita. Role of insulin signaling in the interaction between Alzheimer disease and diabetes mellitus: a missing link to therapeutic potential. Current Aging Science, 2011 Jul;4(2):118-27.
Shuko Takeda, Naoyuki Sato, Kazuko Ikimura, Hirohito Nishino, Hiromi Rakugi and Ryuichi Morishita. Novel microdialysis method to assess neuropeptides and large molecules in free-moving mouse. Neuroscience, 2011 Jul 14;186:110-9.
Shuko Takeda, Naoyuki Sato, Kozue Uchio-Yamada, Hisahiro Yu, Atsushi Moriguchi, Hiromi Rakugi, and Ryuichi Morishita. Oral Glucose Loading Modulates Plasma β-Amyloid Level in Alzheimer's Disease Patients: Potential Diagnostic Method for Alzheimer's Disease. Dementia and Geriatric Cognitive Disorders, 2012;34(1):25-30.
Naoyuki Sato, Masayasu Okochi, Mitsuru Shinohara, Gopal Thinakaran, Shuko Takeda, Akio Fukumori, Motoko Shinohara-Noma, Mari Mori-Ueda, Hizuki Hamada, Masatoshi Takeda, Hiromi Rakugi, Ryuichi Morishita. Differential Regulation of Amyloid Precursor Protein /Presenilin 1 Interaction during Aβ40/42 Production Detected Using Fusion Constructs. PLoS ONE 2012;7(11): e48551. doi:10.1371/journal.pone.0048551
Naoyuki Sato, Ryuichi Morishita. Plasma Abeta: A Possible Missing Link Between Alzheimer Disease and Diabetes. DIABETES, 62, 1005-1006, 2013
Shuko Takeda,Naoyuki Sato, Kazuko Ikimura, Hirohito Nishino, Hiromi Rakugi and Ryuichi Morishita. Increased Blood-Brain Barrier Vulnerability to Systemic Inflammation in Alzheimer Disease Mouse Model. Neurobiology of Aging, 2013, in press

Review Articles

Miki T, Nakura J, Ye L, Mitsuda N, Morishima A, Sato N, Kamino K, Ogihara T. Molecular and epidemiological studies of Werner syndrome in the Japanese population. Mech Ageing Dev. 98, 255-65, 1997.
Thinakaran G, Bowen JW, Ito D, Leem JY, Veselits ML, Sato N. Investigation of unfolded-protein response in cells expressing familial Alzheimer's disease-linked presenilin variants. Methods Mol Biol. 232, 203-16, 2003.
Sato N, Shimamura M, Morishita R. Recent Progress in Cerebrovascular Gene Therapy. Current Neurovascular Research. 2, 235-247, 2005.
Shimamura, M., Sato, N., Yoshimura S, Kaneda, Y., Morishita, R. HVJ-based non-viral gene transfer method: successful gene therapy using HGF and VEGF genes in experimental ischemia Frontiers in Bioscience. 11, 753-759, 2006.
Sato N, Shimamura M, Takeuchi D, Kurinami H, Ogihara T, Morishita R. Gene Therapy for Ischemic Brain Disease with special reference to Vascular Dementia. Geriatrics and Gerontology International. 2006.
Takeda S, Sato N, Ogihara T, Morishita R. The Renin-Angiotensin System, Hypertension and cognitive dysfunction in Alzheimer's Disease: New Therapeutic Potential. Frontiers in Bioscience. 13, 2253-65, 2008.
Fournier A, Oprisiu-Fournier R, Serot JM, Godefroy O, Achard JM, Faure S, Mazouz H, Temmar M, Albu A, Bordet R, Hanon O, Gueyffier F, Wang J, Black S, Sato N. Prevention of dementia by antihypertensive drugs: how AT1-receptor-blockers and dihydropyridines better prevent dementia in hypertensive patients than thiazides and ACE-inhibitors. Expert Rev Neurother. 9(9):1413-31, 2009.
Shuko Takeda, Naoyuki Sato, Hiromi Rakugi, and Ryuichi Morishita. Plasma Beta-Amyloid as Potential Biomarker of Alzheimer Disease: Possibility of Diagnostic Tool of Alzheimer Disease. Molecular BioSystems, 2010, 6, 1760-1766
Naoyuki Sato, Shuko Takeda, Kozue Uchio-Yamada, Hironori Ueda, Tomomi Fujisawa, Hiromi Rakugi, Ryuichi Morishita. Role of insulin signaling in the interaction between Alzheimer disease and diabetes mellitus: a missing link to therapeutic potential. Current Aging Science, 2011 Jul;4(2):118-27.
Sato N and Morishita R. Roles of Vascular and Metabolic Components in Cognitive Dysfunction of Alzheimer disease: Short- and Long-term Modification by Non-genetic Risk Factors. Front. Aging Neurosci. 5:64. doi: 10.3389/fnagi.2013.00064, 2013.
Naoyuki Sato and Ryuichi Morishita. Brain alterations and clinical symptoms of dementia in diabetes: Aβ/tau-dependent and independent mechanisms. Frontiers in Endocrinology. Front. Endocrinol. | doi: 10.3389/fendo.2014.00143