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Bibliography (Original articles)

  1. Higaki J, Ogihara T, Nakamaru M, Morishita R, Kumahara Y. Effects of carvedilol on plasma hormonal and biochemical factors and renal function in Japanese patients with essential hypertension. Drugs 1988,36:64-68.
  2. Higaki J; Okuno M; Nakamaru M; Morishita R; Himeno S; Ogihara T. Changes in plasma active renin and prorenin after endoscopic retrograde pancreatography. Methods and Findings in Experimental and Clinical Pharmacology 1989;11:703-705.
  3. Morishita R; Higaki J; Ogihara T. Endothelin stimulates aldosterone biosynthesis by dispersed rabbit adreno-capsular cells. Biochemical and Biophysical Research Communications 1989;160:628-632.
  4. Higaki J; Morishita R; Ogihara T. Measurements of enzyme activity and immunoreactivity of plasma renin. Limitations of the conventional method for assay of plasma renin catalytic activity. Journal of Clinical Chemistry and Clinical Biochemistry, 1989;27:201-204.
  5. Higaki J; Morishita R; Ogihara T; Nishiura M. Effects of aging on human plasma renin: simultaneous multiple assays of enzyme activity and immunoactivity of plasma renin. Acta Endocrinologica, 1989;120:81-86.
  6. Higaki J, Morishita R, Nakamaru M, Mikami H, Ogihara T. Thiazide-induced cerebral infarction in an elderly hypertensive patients with carotid artery stenosis. Advances in Therapy. 1989;6:180-185.
  7. Morishita R; Higaki J; Mikami H; Ogihara T. Effect of cyclosporin A on aldosterone production by dispersed rabbit adreno-capsular cells. Life Sciences, 1990, 46:1985-1989.
  8. Higaki J, Mikami H, Otsuka A, Iwatsubo H, Katahira K, Moriguchi A, Morishita R, Hata T, Ogihara T. Effect of two years of enalapril treatment on the quality of ligfe of elderly patients with essential hypertension complicated by other diseases. Current Therapeutic Research 1990;47:620-626.
  9. Nakamura F; Nagano M; Higaki J; Higashimori K; Katahira K; Morishita R; Mikami H; Ogihara T. Regression of left ventricular hypertrophy by angiotensin converting enzyme inhibitor in reduced renal mass hypertensive rats. Journal of Hypertension. 1991;9:S398-399.
  10. Morishita R; Higaki J; Nagano M; Mikami H; Ogihara T; Tanaka T; Ishii K; Okunishi H; Miyazaki M. Consistent activation of prorenin mRNA in renal hypertensive rats. Canadian Journal of Physiology and Pharmacology, 1991;69:1364-1366.
  11. Higaki J; Miya A; Miki T; Morishita R; Mikami H; Takai S; Ogihara T. Contribution of the activation of the ras oncogene to the evolution of aldosterone- and renin-secreting tumors. Journal of Hypertension 1991;9:135-137.
  12. Morishita R; Higaki J; Okunishi H; Tanaka T; Ishii K; Nagano M; Mikami H; Ogihara T; Murakami K; Miyazaki M. Changes in gene expression of the renin-angiotensin system in two-kidney, one clip hypertensive rats. Journal of Hypertension, 1991;9:187-192.
  13. Morishita R, Higaki J, Okunishi H, Kawamoto T, Ishii K, Nakamura F, Katahira K, Nagano M, Mikami H, Miyazaki M, Ogihara T. Effect of long term treatment with an angiotensin converting enzyme inhibitor on the renin angiotensin system in spontaneously hypertensive rats. Clinical and Experimental Pharmacology and Physiology 1991;18:685-690.
  14. Morishita R. Higaki J. Nakamura F. Tomita N. Yu H, Nagano M, Mikami H, Ogihara T. Role of vascular angiotensin II in hypertension induced vascular hypertrophy of spontaneously hypertensive rats. Blood Pressure 1992;1:41-47.
  15. Morishita R; Higaki J; Katahira K, Nakamura F, Nagano M; Mikami H; Okunishi H, Miyazaki M, Ogihara T. Investigation of the fectors of the renin angiotensin system in renal hypertensive rats. Journal of Physiology 1992;446:370.
  16. Katsuya T, Higaki J, Miki T, Nakura J, Ikegami H, Morishita R, Nagano M, Higashimori K, Nakamura F, Mikami H, Ogihara T. Substrain comparison of genetically hypertensive rats using DNA fingerprinting, and genetic analysis of blood pressure in the inbred rats. The Tohoku Journal of Experimental Medicine 1992;165:253-260.
  17. Ogihara T, Ishikawa H, Mikami H, Nonaka H, Higaki J, Kagoshima T, Otsuka A, Higashimori K, Morishita R, Ishikawa K. Effects of long-term treatment with delapril on quality of life in hypertensive patients. Current Therapeutic Research 1992;51:254-260.
  18. Ogihara T, Mikami H, Otsuka A, Nagano M, Matsuo K, Saeki S, Morishita R, Suzuki T, Naka T, Hata T. Effect of nilvadipine on quality of life in patients with essential hypertension. Current Therapeutic Research 1992;51:154-162.
  19. Ogihara T, Nakagawa M, Ishikawa H, Mikami H, Takeda K, Nonaka H, Higaki J, Saeki S, Kagoshima T, Matsuo K, Morishita R, Ishikawa K. The effects of temocapril,. a new angiotensin converting enzyme inhibitor, on the quality of life in hypertensive patients. Current Therapeutics Research 1992;52:81-88.
  20. Tomita N, Higaki J, Morishita R, Kato K, Mikami H, Kaneda Y, Ogihara T. Direct in vivo gene introduction into rat kidney. Biochemical and Biophysical Research Communications 1992;186:129-34.
  21. Morishita R, Higaki J, Nakamura F, Tomita N, Yu H, Nagano M, Mikami H, Ogihara T. Regression of hypertension-induced vascular hypertrophy by an ACE inhibitor and calcium antagonist in the spontaneously hypertensive rat. Blood Pressure 1992;3:41-47.
  22. Morishita R; Higaki J; Miyazaki M; Ogihara T. Possible role of the vascular renin-angiotensin system in hypertension and vascular hypertrophy. Hypertension, 1992 19(Suppl):II62-7.
  23. Morishita R; Higaki J; Mikami H; Matsukawa N; Ogihara T. Effect of aging on the renin angiotensin system in patients with renovascular hypertension. Methods and Findings in Experimental and Clinical Pharmacology, 1992;14:17-21.
  24. Dzau VJ. Morishita R, Gibbons GH. Gene therapy in the cardiovascular diseases. Trends in Biotechnology 1993;11:205-210.
  25. Morishita R, Gibbons GH, Kaneda Y, Ogihara T, Dzau VJ. Novel in vitro gene transfer method for study of local modulators in vascular smooth muscle cells. Hypertension 1993;21:894-899.
  26. Morishita R; Higaki J; Okunishi H, Nakamura F, Nagano M; Mikami H; Ishii K, Miyazaki M, Ogihara T. Role of tissue renin angiotensin system in two-kidney, one clip hypertensive rats. American Journal of Physiology 1993;264:F510-514.
  27. Nakamura F, Nagano M, Higaki J, Higashimori K, Morishita R, Mikami H, Ogihara T. The angiotensin-converting enzyme inhibitor, perindopril, prevents cardiac hypertrophy in low-renin hypertensive rats. Clinical and Experimental Pharmacology and Physiology 1993;20:135-140.
  28. Morishita R. Higaki J. Nagano M. Nakamura F. Tomita N. Zhao Y. Mikami H, Miyazaki M, Ogihara T. Discrepancy between renin mRNA and plasma renin level in angiotensin-converting enzyme inhibitor-treated rats. Clinical and Experimental Pharmacology and Physiology 1993;20:15-20.
  29. Morishita R, Gibbons GH, Kaneda Y, Ogihara T, Dzau VJ. Novel and effective gene transfer technique for study of vascular renin angiotensin system. Journal of Clinical Investigation 1993;91:2580-2585
  30. Morishita R, Gibbons GH, Ellison KE, Nakajima M, Zhang L, Kaneda Y, Ogihara T, Dzau VJ. Single intraluminal delivery of antisense cdc 2 kinase and PCNA oligonucleotides results in chronic inhibition of neointimal hyperplasia. Proc Natl Acad Sci USA 1993;90:8474-8478.
  31. Morishita R, Gibbons GH, Ellison KE, Nakajima M, Leyen HVL, Zhang L, Kaneda Y, Ogihara T, Dzau VJ. Antisense oligonucleotides directed at cell cycle regulatory genes as a target for restenosis therapy. Transactions of Association of American Physicians 1993;106:54-61.
  32. Tomita N, Higaki J, Kaneda Y, Yu H, Morishita R, Mikami H, Ogihara T. Hypertensive rats produced by in vivo introduction of the human renin gene. Circulation Research 1993;73:898-905.
  33. Yu H, Rakugi H, Higaki J, Morishita R, Mikami H, Ogihara T. The role of activated vascular angiotensin II generation in vascular hypertrophy in one-kidney, one clip hypertensive rats. Journal of Hypertension 1993;11:1347-1355.
  34. Morishita R, Gibbons GH, Ellison KE, Nakajima M, Leyen HVL, Zhang L, Kaneda Y, Ogihara T, Dzau VJ. Intimal hyperplasia after vascular injury is inhibited by antisense cdk 2 kinase oligonucleotides. Journal of Clinical Investigation 1994;93:1458-1464.
  35. Morishita R, Rakugi H, Higaki J, Tomita N, Nakamura F, Yu H, Katsuya T, Mikami H, Ogihara T. Differential regulation of brain angiotensin II in genetically hypertensive and normotensive rats after nephrectomy. Blood Pressure 1994:3;265-269.
  36. Morishita R, Gibbons GH, Pratt E, Tomita N, Kaneda Y, Ogihara T- Dzau VJ. Autocrine and paracrine effects of atrial natriuretic peptide gene transfer on vascular smooth muscle and endothelial cellular growth. Journal of Clinical Investigation 1994;94:824-829.
  37. Morishita R, Gibbons GH, Ellison KE, Lee W, Zhang L, Kaneda Y, Ogihara T, Dzau VJ. Evidence for direct local effect of angiotensin in vascular hypertrophy: in vivo gene transfer of angiotensin converting enzyme. Journal of Clinical Investigation 94:978-984,1994.
  38. Morishita R, Higaki J, Yu H, Tomita N, Nakamura F, Mikami H, Ogihara T. Effect of antihypertensive drugs on vascular hypertrophy and vascular angiotensin II in two-kidney, one clip hypertensive rats. Journal of Vascular Medicine and Biology 1994;5:38-45.
  39. Morishita R., Gibbons GH, Kaneda Y, Ogihara T, Dzau VJ. Pharmacokinetics of antisense oligonucleotides (cyclin B1 and cdc 2 kinase) in the vessel wall: enhanced therapeutic utility for restenosis by HVJ-liposome method. Gene 1994;149:13-19.
  40. Katahira K, Mikami H, Otuka A, Moriguchi A, Kohara K, Higashimori K, Okuda N, Nagano M, Morishita R, Ogihara T. Differential control of vascular tone and heart rate by different amino acid neurotransmitters in the rostral ventrolateral medulla of the rat. Clinical and Experimental Physiology and Pharamcology. 1994;21:545-556.
  41. Tomita N, Higaki J, Morishita R, Kaneda Y, Ogihara T. A novel gene transfer technique mediated by HVJ (Sendai virus), nuclear protein and liposomes. Cancer Detection and Prevention. 1994;18:485-491.
  42. Morishita R, Higaki J, Rakugi H, Tomita N, Yu H, Nakamura F, Mikami H, Ogihara T. Effect of antihypertensive drug on brain angiotensin II level in renal and spontaneously hypertensive rats. Clinical and Experimental Physiology and Pharmacology 1995;22;665-669.
  43. Leyen H.V.L., Gibbons G.H., Morishita R., Lewis N.P., Zhang L., Nakajima M., Kaneda Y., Cooke J.P., Dzau V.J. Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of ec-nitric oxide synthase gene. Proc Natl Acad Sci USA 1995;92:1137-1141.
  44. Morishita R, Gibbons GH, Horiuchi M, Ellison KE, Nakajima M, Zhang L, Kaneda Y, Ogihara T, Dzau VJ. A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo. Proceeding of National Academy of Sciences USA 1995;92:5855-5859.
  45. Tomita N, Morishita R, Higaki J, Aoki M, Nakamura Y, Mikami H, Fukamizu A, Murakami K, Kaneda Y, Ogihara T. Transient decrease in high blood pressure by in vivo transfer of antisense oligodeoxynucleotides against rat angiotensinogen. Hypertension 1995;26:131-136.
  46. Yamada T, Horiuchi M, Morishita R, Zhang L, Pratt RE, Dzau VJ. In vivo identification of a negative regulatory element in the mouse renin gene using direct gene transfer. Journal of Clinical Investigation 1995;96:1230-1237.
  47. Tomita N, Morishita R, Higaki J, Tomita S, Aoki M, Kaneda Y, Ogihara T. Role of angiotensinogen in blood pressure regulation in normotensive rats: application of a “loss of function” approach. Journal of Hypertension 1995;13;1767-1774.
  48. Yamada K, Moriguchi A, Mikami H, Higaki J, Morishita R, Aoki M, Okuda N, Ogihara T. Importance of central amino acid neurotransmitter in the blood pressure regulation in the spontaneously hypertensive rat. Journal of Hypertension 1995;13;1624-1630.
  49. Nakamura Y, Morishita R, Higaki J, Kida I, Aoki M, Moriguchi A, Yamada K, Hayashi S, Yo Y, Matsumoto K, Nakamura T. Expression of local hepatocyte growth factor system in vascular tissues. Biochemical Biophysics Research Communication 1995;215:483-488.
  50. Nakajima M, Hutchinson H, Fujinaga M, Hayashida W, Morishita R, Zhang L, Horiuchi M, Pratt RE, Dzau VJ. The AT2 receptor antagonizes the growth effects of the AT1 receptor: gain of function study using gene transfer. Proceeding of National Academy of Sciences USA 1995;92:10663-10667.
  51. Hara S, Morishita R, Tone Y, Yokoyama C, Inoue H, Kaneda Y, Ogihara T, Tanabe T. Overexpression of prostacyclin synthase inhibits growth of vascular smooth muscle cells. Biochemical Biophysics Research Communication 1995;216:862-867.
  52. Sawa Y, Suzuki K, Bai HZ, Shirakura R, Morishita R, Kaneda Y, Matsuda H. Efficiency of in vivo gene transfection into transplanted rat heart by coronary infusion of HVJ-liposome. Circulation 1995;92:II-479-482.
  53. Ellison KE, Bishopric NH, Webster KA, Morishita R, Gibbson GH, Kaneda Y, Sato B, Dzau VJ, Fusigenic liposome-mediated DNA transfer into cardiac myocytes. Journal of Molecular and Cellular Cardiology 1995;28:1385-1399.
  54. Morishita R, Higaki J, Tomita N, Aoki M, Moriguchi A, Tamura K, Murakami K, Kaneda Y, Ogihara T. Role of transcriptional cis-elements, angiotensinogen gene-activating element, of angiotensinogen gene in blood pressure regulation. Hypertension 1996;27:502-507.
  55. Hayashi S, Morishita R, Higaki J, Aoki M, Moriguchi A, Kida I, Sawa Y, Matsumoto K, Nakamura T, Kaneda Y, Ogihara T. Autocrine-paracrine effects of over-expression of hepatocyte growth factor gene on growth of endothelial cells. Biochemical Biophysics Research Communication 1996;220:539-545.
  56. Tomita N, Morishita R, Higaki J, Tomita S, Aoki M, Ogihara T, Kaneda Y. In vivo gene transfer of insulin gene into neonatal rats by HVJ-liposome method resulted in sustained transgene expression. Gene Therapy 1996:3;477-482.
  57. Tomita N, Morishita R, Higaki J, Tomita S, Aoki M, Kaneda Y, Ogihara T. Transfection of renin gene into neonates results in sustained gene expression, but fails to produce sustained hypertension. Biochemical Biophysics Research Communication 1996;224:43-49.
  58. Nakamura Y, Morishita R, Higaki J, Kida I, Aoki M, Moriguchi A, Yamada K, Hayashi S, Yo Y, Nakano H, Matsumoto K, Nakamura T, Ogihara T. Hepatocyte growth factor (HGF) ia a novel member of endothelium-specific growth factors: additive stimulatory effect of HGF with basic fibroblast growth factor, but not vascular endothelial growth factor. Journal of Hypertension 1996;14:1067-1072.
  59. Yamada K, Moriguchi A, Morishita R, Aoki M, Nakamura Y, Mikami H, Oshima T, Ninomiya M, Kaneda Y, Higaki J, Ogihara T. Efficient oligonucleotides delivery using HVJ-liposome method in the central nervous system. American Journal of Physiology 1996;40:R1212-1220.
  60. Nakamura Y, Morishita R, Nakamura S, Aoki M, Moriguchi A, Matsumoto K, Nakamura T, Higaki J, Ogihara T. A vascular modulator, hepatocyte growth factor, is associated with systolic pressure. Hypertension 1996;28:409-413
  61. Hayashi S, Morishita R, Aoki M, Moriguchi A, Kida I, Nakajima M, Kaneda Y, Higaki J, Ogihara T. In vivo transfer of gene and oligodeoxynucleotides into skin of fetal rats by incubation in amniotic fluid. Gene Therapy 1996;3:878-885.
  62. Yonemitsu Y, Kaneda Y, Morishita R, Nakagawa K, Nakashima Y, Sueishi K. Characterization of in vivo gene transfer into the arterial wall mediated by the Sendai virus (Hemagglutinating Virus of Japan) liposomes: an effective tool for the in vivo study of arterial diseases. Laboratory Investigation 1996;75:313-323.
  63. Morishita R, Gibbons GH, Horiuchi M, Nakajima M, Ellison KE, Lee W, Kaneda Y, Ogihara T, Dzau VJ, Molecular delivery system for antisense olgonucleotides: enhanced effectiveness of antisense oligonucleotides by HVJ-liposome mediated transfer. Journal of Cardiovascular Pharmacology & Therapeutics 1996;2:213-222.
  64. Morishita R, Nakamura S, Nakamura Y, Aoki M, Moriguchi A, Kida I, Yo Y, Matsumoto K, Nakamura T, Higaki J, Ogihara T. Potential role of endothelium-specific growth factor, hepatocyte growth factor, on endothelial damage in diabetes mellitus. Diabetes 1997;46:138-142.
  65. Aoki M, Morishita R, Higaki J, Moriguchi A, Hayashi S, Matsushita H, Kida I, Tomita N, Sawa Y, Kaneda Y, Ogihara T. Survival of grafts of genetically modified cardiac myocytes transfected with FITC-labeled oligodeoxynucleotides and β-galactosidase gene in non-infarcted area, but not myocardial infarcted area. Gene Therapy 1997;4:120-127.
  66. Aoki M, Morishita R, Higaki J, Moriguchi A, Kida I, Hayashi S, Matsushita H, Kaneda Y, Ogihara T. In vivo transfer efficiency of antisense oligonucleotides into the myocardium using HVJ-liposome method. Biochemical Biophysics Research Communications 1997;231:540-545.
  67. Aoki M, Morishita R, Muraishi A, Moriguchi A, Sugimoto T, Maeda K, Dzau VJ, Kaneda Y, Higaki J, Ogihara T. Efficient in vivo gene transfer into heart in rat myocardial infarction model using HVJ (Hemagglutinating Virus of Japan)-liposome method. Journal of Molecular and Cellular Cardiology 1997;29:949-959.
  68. Rakugi H, Okamura A, Kamide K, Ohishi M, Sasamura H, Morishita R, Higaki J, Ogihara T. Recognition of tissue- and subtype-specific modulation of angiotensin II receptors using antibodies against AT1 and AT2 receptors. Hypertension Research 1997;20:51-55.
  69. Morishita R, Higaki J, Hayashi S, Yo Y, Aoki M, Nakamura S, Moriguchi A, Matsushita H, Matsumoto K, Nakamura T, Ogihara T. Role of hepatocyte growth factor in endothelial regulation: Prevention of high D-glucose-induced endothelial cell death by prostaglandins and phosphodiesterase type 3 inhibitor. Diabetologia 1997;40:1053-1061.
  70. Tomita T, Hashimoto H, Tomita N, Morishita R, Bak Lee S, Hayashida K, Nakamura N, Yonenobu K, Kaneda Y, Ochi T. In vivo eirect gene transfer into articular cartilage by intraarticular injection mediated by HVJ (Sendai virus) and liposomes. Arthritis & Rheumatism 1997;40:901-906.
  71. Morishita R, Sugimoto T, Aoki M, Kida I, Tomita N, Moriguchi A, Maeda K, Sawa Y, Kaneda Y, Higaki J, Ogihara T. In Vivo Transfection of cis element "decoy" against NFkB binding site prevented myocardial infarction as gene therapy. Nature Medicine 1997;3:894-899.
  72. Suzuki J, Isobe M,Morishita R, Aoki M, Horie S, Okubo Y, Kaneda Y, Sawa Y, Matsuda H, Ogihara T, Sekiguchi M. Prevention of graft coronary arteriosclerosis by antisense cdk 2 kinase oligonucleotide. Nature Medicine 1997;3:900-903.
  73. Aoki M, Morishita R, Matsushita H, Nakano N, Hayashi S, Tomita N, Yamamoto K, Moriguchi A, Higaki J, Ogihara T. Serum deprivation induced apoptosis accompanied by up-regulation of p53 and bax in human aortic vascular smooth muscle cells. Heart & Vessels 1997;S12:71-75.
  74. Sawa Y, Morishita R, Suzuki K, Kagisaki K, Kaneda Y, Maeda K, Kadoba K, Matsuda H. A novel strategy for myocardial protection using in vivo transfection of cis element “decoy” against NFkB binding site: evidence for a role of NFkB in ischemic-reperfusion injury. Circulation 1997;96:II-280-285.
  75. Nakano N, Moriguchi A, Morishita R, Kida I, Tomita N, Matsumoto K, Nakamura T, Higaki J, Ogihara T. Role of angiotensin II in the regulation of a novel vascular modulator, hepatocyte growth factor, in experimental hypertensive rats. Hypertension 1997;30:1448-1454.
  76. Yo Y, Morishita R, Yamamoto K, Tomita N, Kida I, Hayashi S, Moriguchi A, Kato S, Matsumoto K, Nakamura T, Higaki J, Ogihara T. Actions of Hepatocyte Growth Factor as a Local Modulator in the Kidney: Potential Role in Pathogenesis of Renal Disease. Kidney International 1998;53:50-58.
  77. Matsushita H, Morishita R, Kida I, Aoki M, Hayashi S, Tomita N, Yamamoto K, Moriguchi A, Noda A, Kaneda Y, Higaki J, Ogihara T. Inhibition of growth of human vascular smooth muscle cells by over-expression of p21 gene through induction of apoptosis. Hypertension 1998;31:493-498.
  78. Matsumoto T, Komori K, Yonemitsu Y, Morishita R, Sueishi K, Kaneda Y, Sugimachi K. Hemagglutinating virus of Japan-liposome mediated gene transfer of endothelial cell nitric oxide synthase inhibits intimal hyperplasia of canine vein grafts under conditions of poor runoff. Journal of Vascular Surgery 1998;27:125-144.
  79. Nakamura S, Moriguchi A, Morishita R, Aoki M, Yo Y, Hayashi S, Nakano N, Katsuya T, Nakata S, Takami S, Matsumoto K, Nakamura T, Higaki J, Ogihara T. A novel vascular modulator, hepatocyte growth factor (HGF), as a potential index of the severity of hypertension. Biochemical Biophysics Research Communication 1998;242:238-243
  80. Morishita R, Gibbons GH, Horiuchi M, Kaneda Y, Ogihara T, Dzau VJ. Role of AP-1 complex in angiotensin II-mediated transforming growth factor-β expression and growth of smooth muscle cells:using decoy approach against AP-1 binding site. Biochemical Biophysics Research Communication 1998;243:361-367.
  81. Hirano T, Fujimoto J, Ueki T, Yamamoto H, Iwasaki T, Morishita R, Sawa Y, Kaneda Y, Takahashi H, Okamoto E. Persistent gene expression in rat liver in vivo by repetitive transfections using HVJ-liposome. Gene Therapy 1998;5:459-464.
  82. Ono S, Date I, Onoda K, Shiota T, Ohmoto T, Ninomiya Y, Asari S, Morishita R. Decoy administration of NFkB into the subarachnoid space for cerebral angiopathy. Human Gene Therapy 1998;9:1003-1011.
  83. Suzuki J, Isobe M, Morishita R; Aoki M, Yamazaki S, Kaneda Y, Sawa Y, Matsuda H, Ogihara T, Horie S, Okubo Y, Sekiguchi M. Antisense Cdk2 kinase oligodeoxynucleotide inhibits ICAM-1 expression in murine cardiac allograft arteriopathy. Transplant Proc 1998;30:89-90.
  84. Tomita N, Morishita R, Tomita S, Yamamoto K, Aoki M, Matsushita H, Hayashi S, Higaki J, Ogihara T. Transcription factor decoy for NFkB inhibits TNF-α-induced IL-6 and ICAM-1 expression in endothelial cells. Journal of Hypertension 1998;16:993-1000.
  85. Isobe M, Suzuki J, Morishita R, Aoki M, Amano J, Kaneda Y, Sawa Y, Matsuda H, Ogihara T, Horie S, Okubo Y, Sekiguchi M. Downregulation of endothelin-1 expression in allograft coronary arteries after gene therapy targeting cdk2 kinase. Transplantation Proceedings 1998;30:1007-1008
  86. Bai HZ, Morishita R, Kida I, Yamakawa T, Zhang WD, Aoki M, Matsushita H, Noda A, Nagai R, Kaneda Y, Higaki J, Ogihara T, Sawa Y, Matsuda H. Inhibition of intimal hyperplasia after vein grafting by in vivo transfer of human senescent cell-derived inhibitor-1 gene. Gene Therapy 1998;5:761-769.
  87. Morishita R, Yamada S, Higaki J, Tomita N, Kida I, Aoki M, Moriguchi A, Hayashi S, Sakurabayashi I, Kaneda Y, Ogihara T. Conditioned medium from HepG2 cells transfected with human apolipoprotein (a) gene stimulates growth of human vascular smooth muscle cells: effects of over-expression of human apolipoprotein (a) gene. Hypertension 1998;32:215-222.
  88. Morishita R, Yamamoto K, Yamada S, Matsushita H, Tomita N, Sakurabayashi I, Kaneda Y, Moriguchi A, Higaki J, Ogihara T. Stimulatory effect of lipoprotein (a) on proliferation of human mesangial cells: role of lipoprotein (a) in renal disease. Biochemical Biophysics Research Communication 1998;249:313-320
  89. Nakano N, Morishita R, Moriguchi A, Nakamura Y, Hayashi S, Aoki M, Kida I, Matsumoto K, Nakamura T, Higaki J, Ogihara T. Negative regulation of local hepatocyte growth factor (HGF) expression by angiotensin II and transforming growth factor-β in blood vessels: potential role of HGF in cardiovascular disease. Hypertension 1998;32:444-451
  90. Yo Y, Morishita R, Nakamura S, Tomita N, Yamamoto K, Moriguchi A, Matsumoto K, Nakamura T, Higaki J, Ogihara T. Potential role of hepatocyte growth factor in the maintenance of renal structure: anti-apoptotic action of HGF on epithelial cells. Kidney International 1998:54:1128-1138
  91. Morishita R, Yamada S, Yamamoto K, Tomita N, Kida I, Sakurabayashi I, Kikuchi A, Kaneda Y, Lawn R, Higaki J, Ogihara T. Novel therapeutic strategy for atherosclerosis: ribozyme oligonucleotides against apolipoprotein (a) selectively inhibit apolipoprotein (a), but not plasminogen, gene expression. Circulation 1998;98:1898-1904
  92. Sawa Y, Kaneda Y, Bai HZ, Suzuki K, Fujimoto J, Morishita R, Matsuda H. Efficient transfer of oligonucleotides and plasmid DNA into the whole heart through the coronary artery. Gene Therapy 1998;5;1472-1480.
  93. Nakamura S, Morishita R, Moriguchi A, Yo Y, Nakamura Y, Hayashi S, Matsumoto K, Nakamura T, Higaki J, Ogihara T. Hepatocyte growth factor as a potential index of complication in diabetes mellitus. Journal of Hypertension 1998;16:2019-2026.
  94. Kawamura I, Morishita R, Tomita N, Elizabeth L, Aketa M, Tsujimoto S, Manda T, Tomoi M, Kida I, Higakai J, Kaneda Y, Shimomura K, Ogihara T. Intratumoral injection of oligonucleotides to the NFkB binding site inhibits cachexia in a mouse tumor model. Gene Therapy 1999;6;91-97
  95. Ueki T, Kaneda Y, Tsutsui H, Nakanishi K, Sawa Y, Morishita R, Matsumoto K, Nakamura T, Takahashi H, Oakamoto E, Fujimoto J. Curative gene therapy of liver cirrhosis by hepatocyte growth factor in rats. Nature Medicine 1999;5:226-230
  96. Todaka T, Yokoyama C, Yanamoto H, Hashimoto N, Nagata I, Tsukahara T, Hara S, Hatae T, Morishita R, Aoki M, Ogihara T, Kaneda Y, Tanabe T. Gene transfer of human prostacyclin synthase prevents neointimal formation after carotid balloon injury in rats. Stroke 1999;30:419-426.
  97. Tomita S, Tomita N, Yamada T, Xhang L, Kaneda Y, Morishita R, Ogihara T, Dzau VJ, Horiuchi M. Transcription factor decoy to syudy the molecular mechanism of negative regulation of renin gene expression in the liver in vivo. Circulation Research 1999;84:1059-1066.
  98. Morishita R, Nakamura S, Hayashi S, Taniyama Y, Moriguchi A, Nagano T, Taiji M, Noguchi H, Takeshita S, Matsumoto K, Nakamura T, Higaki J, Ogihara T. Therapeutic angiogenesis induced by human recombinant hepatocyte growth factor in rabbit hind limb ischemia model as “cytokine supplement therapy” Hypertension 1999;33:1379-1384
  99. Nishii T, Moriguchi A, Morishita R, Yamada K, Nakamura S, Tomita N, Kaneda Y, Fukamizu A, Mikami H, Higaki J, Ogihara T. Angiotensinogen gene activating elements regulate blood pressure in the brain. Circulation Research 1999;85:257-263.
  100. Aoki M, Morishita R, Matsushita H, Hayashi S, Nakagami H, Yamamoto K, Moriguchi A, Kaneda Y, Higaki J, Ogihara T. Inhibition of the p53 tumor suppressor gene resulted in growth of human aortic vascular smooth muscle cells (VSMC): potential role of p53 in regulation of VSMC growth. Hypertension 1999;34:192-200
  101. Matsumoto K, Morishita R, Moriguchi A, Tomita N, Yo Y, Nishii T, Matsumoto K, Nakamura T, Higaki J, Ogihara T. Prevention of renal damage by angiotensin II blockade, accompanied by increased renal hepatocyte growth factor in experimental hypertensive rats. Hypertension 1999;34:279-284
  102. Nakamura S, Moriguchi A, Morishita R, Yamada K, Nishii T, Tomita N, Oishi M, Kaneda Y, Higaki J, Ogihara T. Activation of the brain angiotensin system by in vivo human angiotensin converting enzyme gene transfer in rats. Hypertension 1999;34:302-308.
  103. Zhou WZ, Kaneda Y, Huang SKS, Morishita R, Hoon DSB. Protective immunization against melanoma by gp100 DNA HVJ-liposome vaccine. Gene Therapy 1999;6:1768-1773
  104. Yamada S, Inoue K, Morishita R, Ogihara T, Kubono K, Kubo N, Abe A, Sakurabayashi I. A new Lp(a) assay that is unaffected by apo(a) size polymorphism. Clinica Chimica Acta 1999;287:29-43.
  105. Suzuki J, Isobe M, Morishita R, Izawa A, Yamazaki S, Okubo Y, Kaneda Y, Sekiguchi M. E2F decoy suppresses E-selectin expression in murine cardiac allograft arteriopathy. Transplant Proc 1999;31:2018-2019
  106. Suzuki J, Izawa A, Morishita R, Kaneda Y, Sawa Y, Okubo Y, Ogihara T, Sekiguchi M, Isobe M. Antisense Cdc2 kinase oligonucleotide inhibits adhesion molecule expression in cardiac allograft arteriopathy. Transplant Proc 1999;31:955-956
  107. Suzuki J, Izawa A, Morishita R, Kaneda Y, Sawa Y, Okubo Y, Ogihara T, Sekiguchi M, Isobe M. Prevention of cardiac allograft arteriopathy by antisense Cdc2 kinase oligonucleotide. Transplant Proc 1999;31:867-868
  108. Hayashi S, Morishita R, Nakamura S, Yamamoto K, Moriguchi A, Nagano T, Taizi M, Noguchi H, Matsumoto K, Nakamura T, Higaki J, Ogihara T. Potential role of hepatocyte growth factor, a novel angiogenic growth factor, in peripheral arterial disease: down-regulation of HGF in response to hypoxia in vascular cells. Circulation 1999;100:II301-II308.
  109. Zhou WZ, Hoon DSB, Huang SKS, Fujii S, Hashimoto K, Morishita R, Kaneda Y. RNA melanoma vaccine: induction of anti-tumor immunity by human gp100 mRNA immunization. Human Gene Therapy 1999;10:2719-2724
  110. Tomita T, Takeuchi E, Tomita N, Morishita R, Kaneko M, Yamamoto K, Nakase T, Seki H, Kato K, Kaneda Y, Ochi T. Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor kappaB decoy oligodeoxynucleotides as a gene therapy. Arthritis Rheum 1999;42:2532-2542
  111. Hayashi Si, Morishita R, Matsushita H, Nakagami H, Taniyama Y, Nakamura T, Aoki M, Yamamoto K, Higaki J, Ogihara T. Cyclic AMP Inhibited Proliferation of Human Aortic Vascular Smooth Muscle Cells, Accompanied by Induction of p53 and p21. Hypertension 2000;35:237-243
  112. Higaki J, Aoki M, Morishita R, Kida I, Taniyama Y, Tomita N, Yamamoto K, Moriguchi A, Kaneda Y, Ogihara T. In vivo evidence of importance of cardiac angiotensin converting enzyme in the pathogenesis of cardiac hypertrophy. Arteriosclerosis, Thrombosis & Vascular Biology 2000;20:428-434.
  113. Suzuki J, Isobe M, Morishita R, Nishikawa T, Amano J, Kaneda Y. Antisense bcl-x oligonucleotide induces apoptosis and prevents arterial neointimal formation in murine cardiac allografts. Cardiovascular Research 2000;45:783-787.
  114. Kaneda Y, Saeki Y, Nakabayashi M, Zhou WZ, Wataya-Kaneda M, Morishita R. Enhancement of transgene expression by cotransfection of oriP plasmid with EBNA-1 expression vector. Human Gene Therapy 2000;11:471-479.
  115. Aoki M, Morishita R, Taniyama Y, Kida I, Moriguchi A, Matsumoto K, Nakamura T, Kaneda Y, Higaki J, Ogihara T. Angiogenesis induced by hepatocyte growth factor in non-infarcted myocardium and infarcted myocardium: up-regulation of essential transcription factor for angiogenesis, ets. Gene Therapy 2000;7:417-427
  116. Suzuki K, Nakashima H, Sawa Y, Morishita R, Matsuda H, Kaneda Y. Reconstituted fusion liposomes for gene transfer in vitro and in vivo. Gene Therapy & Regulation. 2000;1:65-77.
  117. Morishita R, Gibbons GH, Tomita N, Zhang L, Kaneda Y, Ogihara T, Dzau VJ. Antisense oligodeoxynucleotide inhibition of vascular angiotensin converting enzyme expression attenuates neointimal formation: evidence for tissue ACE function. Arteriosclerosis, Thrombosis & Vascular Biology 2000;20:915-922.
  118. Matsushita H, Morishita R, Aoki M, Tomita N, Taniyama Y, Nakagami H, Shimozato T, Higaki J, Kaneda Y, Ogihara T. Transfection of antisense p53 tumor suppressor gene oligodeoxynucleotides into rat carotid artery resulted in abnormal growth of vascular smooth muscle cells. Circulation 2000;101:1447-1452
  119. Matsushita H, Morishita R, Nata T, Aoki M, Nakagami H, Taniyama Y, Yamamoto K, Higaki J, Kaneda Y, Ogihara T. Hypoxia induced endothelial apoptosis through NFkB-mediated bcl-2 suppression: in vivo evidence of importance of NFkB in endothelial cell regulation. Circulation Research 2000;86:974-981
  120. Yamano H, Ura K, Morishita R, Nakajima H, Monden M, Kaneda Y. Amplification of transgene expression in vitro and in vivo using a novel inhibitor of histone deacteylase. Molecular Therapy 2000;1:574-580.
  121. Taniyama Y, Morishita R, Nakagami H, Moriguchi A, Sakonjo H, Kim S, Matsumoto K, Nakamura T, Higaki J, Ogihara T. Potential contribution of a novel anti-fibrotic factor, hepatocyte growth factor, to prevention of myocardial fibrosis by angiotensin II blockade in cardiomyopathic hamster. Circulation 2000;102:246-252
  122. Tomita N, Morishita R, Lan HY, Yamamoto K, Hashizume M, Notakae M, Toyosawa K, Fujitani B, Mu W, Nikolic-Paterson DJ, Atkins RC, Kaneda Y, Higaki J, Ogihara T. In vivo administration of a nlear transcription factor-kappaB decoy suppresses experimental crescentic glomerulonephritis. Journal of American Society of Nephrology 2000;11:1244-1252
  123. Morishita R, Gibbons GH, Kaneda Y, Ogihara T, Dzau VJ. Systemic administration of HVJ viral coat-liposome complex containing human insulin vector decreases glucose level in diabetic mouse: a model of gene therapy. Biochemical Biophysics Research Communication 2000;273:666-674
  124. Tomita T, Takano H, Tomita N, Morishita R, Kaneko M, Shi K, Takahi K, Nakase T, Kaneda Y, Yoshikawa H, Ochi T. Transcription factor decoy for nuclear factor kappaB inhibits cytokine and adhesion molecule expressions in synovial cells derived from rheumatoid arthritis. Rheumatology 2000;39:749-757
  125. Tomita N, Morishita R, Tomita S, Gibbons GH, Zhang L, Horiuchi M, Kaneda Y, Higaki J, Ogihara T, Dzau VJ. Transcription factor decoy for NFkB inhibits TNF-α-induced cytokine and adhesion molecule expression in vivo. Gene Therapy 2000;7:1326-1332
  126. Yamamoto K, Morishita R, Tomita N, Shimozato T, Nakagami H, Kikuchi A, Aoki M, Higaki J, Kaneda Y, Ogihara T. Ribozyme oligonucleotides against transforming growth factor-β inhibited neointimal formation after vascular injury in rat model: potential application of ribozyme strategy to treat cardiovascular disease. Circulation 2000;102:1308-1314
  127. Kitamoto S, Egashira K, Kataoka C, Koyanagi M, Katoh M, Shimokawa H, Morishita R, Kaneda Y, Sueishi K, Takeshita A. Increased activity of nuclear factor-kappaB participates in cardiovascular remodeling induced by chronic inhibition of nitric oxide synthesis in rats. Circulation. 2000;102:806-812.
  128. Egashira K, Koyanagi M, Kitamoto S, Ni W, Kataoka C, Morishita R, Kaneda Y, Akiyama C, Nishida K, Takeshita A. Anti-monocyte chemoattractant protein-1 gene therapy inhibits vascular remodeling in rats. FASEB Journal 2000;14:1974-1978
  129. Suzuki J, Isobe M, Morishita R, Nishikawa T, Amano J, Kaneda Y. Prevention of cardiac allograft arteriosclerosis using antisense proliferating-cell nuclear antigen oligonucleotide. Transplantation 2000;70:398-400
  130. Morishita R. Adventure of gene therapy into the brain: a new era for cardiovascular gene therapy (Editorial). Circulation research 2000;87:719-721.
  131. Nakagami H, Morishita R, Yamamoto K, Taniyama Y, Aoki M, Kim S, Matsumoto K, Nakamura T, Higaki J, Ogihara T. Anti-apoptotic action of hepatocyte growth factor (HGF) through mitogen-activated protein kinase on human aortic endothelial cells. Journal of Hypertension 2000;18:1411-1420
  132. Hayashi K, Nakamura S, Morishita R, Moriguchi A, Aoki M, Matsumoto K, Nakamura T, Kaneda Y, Sakai N, Ogihara T. In vivo transfer of human hepatocyte growth factor gene accelerates re-endothelialization and inhibits neointimal formation after balloon injury in rat model. Gene Therapy 2000;7:1664-1671
  133. Suzuki J, Morishita R, Amano J, Kaneda Y, Isobe M. Decoy against nuclear factor-kappa B attenuates myocardial cell infiltration and arterial neointimal formation in murine cardiac allografts. Gene Therapy 2000;7:1847-1852.
  134. Yamada S, Morishita R, Nakamura S, Ogihara T, Kusumi Y, Sakurai I, Kubo N, Sakurabayashi I. Development of antibody against epitope of lipoprotein (a) modified by oxidation: evaluation of new enzyme-linked immunoassay for oxidized Lp (a). Circulation 2000;102:1639-1644.
  135. Nagaya N, Yokoyama C, Kyotani S, Shimonishi M, Morishita R, Uematsu M, Nishikimi T, Nakanishi N, Ogihara T, Yamagishi M, Miyatake K, Kaneda Y, Tanabe T. Gene transfer of human prostacyclin synthase ameliorates monocrotaline-induced pulmonary hypertension in rats. Circulation 2000;102:2005-2010.
  136. Hayashi I, Majima M, Fujita T, Okumura T, Kumagai Y, Tomita N, Morishita R, Higaki J, Ogihara T. In vivo transfer of antisense oligonucleotide against urinary kininase blunts deoxycorticosterone acetate-salt hypertension in rats. Br J Pharmacol. 2000;131:820-826.
  137. Kawauchi M, Suzuki J, Morishita R, Wada Y, Izawa A, Tomita N, Amano J, Kaneda Y, Ogihara T, Takamoto S, Isobe M. Gene Therapy for attenuating cardiac allograft arteriopathy using ex vivo E2F decoy transfection by HVJ-AVE-liposome method in mice and nonhuman primates. Circulation Research 2000;87:1063-1068
  138. Okada M, Hojo Y, Ikeda U, Takahashi M, Takizawa T, Morishita R, Shimada K. Interaction between monocytes and vascular smooth muscle cells induces expression of hepatocyte growth factor. J Hypertens. 2000;18:1825-1831.
  139. Shinmura K, Morishita R, Aoki M, Higaki J, Ogihara T, Kaneda Y, Tani M. Catheter-delivered in vivo gene transfer into rat myocardium using the fusigenic liposomal mediated method. Jpn Heart J. 2000;41:633-647.
  140. Sugimoto T, Mine H, Horii Y, Takahashi K, Nagai R, Morishita R, Komada M, Asada Y, Sawada T. Neuroblastoma cell lines showing smooth muscle cell phenotypes. Diagn Mol Pathol. 2000;9:221-228.
  141. Higaki J, Katsuya T, Morishita R, Ogihara T. Hypertension and Genes. Internal Medicine. 2001;40:144-147.
  142. Nakagami H, Morishita R, Yamamoto K, Taniyama Y, Aoki M, Matsumoto K, Nakamura T, Kaneda Y, Horiuchi M, Ogihara T. Mitogenic and anti-apoptotic actions of HGF through ERK, STAT3 and Akt in endothelial cells. Hypertension 2001;37:581-586
  143. Matsumoto K, Morishita R, Moriguchi A, Tomita N, Aoki M, Sakonjo H, Matsumoto K, Nakamura T, Higaki J, Ogihara T. Inhibition of neointima by ACE inhibitor in porcine coronary artery balloon injury model. Hypertension 2001;37:270-274
  144. Tomita N, Morishita R, Higaki J, Ogihara T. Novel molecular therapeutic approach to cardiovascular disease based on hepatocyte growth factor. Journal of Atherosclerosis and Thrombosis. 2001;7:1-7.
  145. Aoki M, Morishita R, Taniyama Y, Kaneda Y, Ogihara T. Therapeutic angiogenesis induced by hepatocyte growth factor: potential gene therapy for ischemic diseases. Journal of Atherosclerosis and Thrombosis. 2001;7:71-76.
  146. Taniyama Y, Morishita R, Aoki M, Nakagami H, Yamamoto K, Yamazaki K, Matsumoto K, Nakamura T, Kaneda Y, Ogihara T. Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat and rabbit hind limb ischemia models: preclinical study for treatment of peripheral arterial disease. Gene Therapy 2001;8:181-189
  147. Tsuboniwa N, Morishita R, Hirano T, Fujimoto J, Furukawa S, Kikumori M, Okuyama A, Kaneda Y. Safety evaluation of hemagglutinating virus of japan-artificial viral envelope liposomes in nonhuman primates. Hum Gene Ther. 2001;12:469-487.
  148. Kawauchi M, Suzuki J, Wada Y, Morishita R, Kaneda Y, Isobe M, Amano J, Takamoto S. Downregulation of nuclear factor kappa B expression in primate cardiac allograft arteries after E2F decoy transfection. Transplant Proc. 2001;33:451.
  149. Tomita N, Morishita R, Tomita S, Kaneda Y, Higaki J, Ogihara T, Horiuchi M. Inhibition of TNF-alpha, induced cytokine and adhesion molecule. expression in glomerular cells in vitro and in vivo by transcription factor decoy for NFkappaB. Experimental Nephrology. 2001;9:181-190
  150. Yamamoto K, Morishita R, Hayashi S, Matsushita H, Nakagami H, Moriguchi A, Matsumoto K, Nakamura T, Kaneda Y, Ogihara T. Contribution of Bcl-2. but not Bcl-xL and Bax, to anti-apoptotic actions of hepatocyte growth factor in hypoxic conditioned human endothelial cells. Hypertension 2001;37:1341-1348.
  151. Nakagami H, Morishita R, Yamamoto K, Yoshimura S, Taniyama Y, Aoki M, Matsubara H, Kim S, Kaneda Y, Ogihara T. Phosphorylation of p38MAP kinase downstream of bax-caspase-3 pathway leads to cell death induced by high D-glucose in human endothelial cells. Diabetes 2001;50:1472-1481.
  152. Kawamura I, Morishita R (equal first author), Tsujimoto S, Manda T, Tomoi M, Tomita N, Goto T, Ogihara T, Kaneda Y. Intravenous injection of oligodeoxynucleotides to the NF-kappaB binding site inhibits hepatic metastasis of M5076 reticulosarcoma in mice. Gene Therapy 2001;8:905-912.
  153. Sakaue G, Shimaoka M, Fukuoka T, Hiroi T, Inoue T, Hashimoto N, Sakaguchi T, Sawa Y, Morishita R, Kiyono H, Noguchi K, Mashimo T. NF-kappaB decoy suppresses cytokine expression and thermal hyperalgesia in a rat neuropathic pain model. Neuroreport. 2001;12:2079-2084.
  154. Ahn JD, Morishita R, Kaneda Y, Lee KU, Park JY, Jeon YJ, Song HS, Lee IK, Transcription factor decoy DON for activator protein-1 (AP-1 inhibits expression of type 1 plasminogen activator inhibitor (PAI-1) gene induced by high glucose and angiotensin II in cultured human vascular smooth muscle cells. Diabetologia 2001;44:713-720.
  155. Izumi Y, Kim S, Namba M, Yasumoto H, Miyazaki H, Hoshiga M, Kaneda Y, Morishita R, Zhan Y, Iwao H. Gene transfer of dominant-negative mutants of extracellular signal-regulated kinase and c-Jun NH2-terminal kinase prevents neointimal formation in balloon-injured rat artery. Circ Res. 2001;88:1120-1126.
  156. Taniyama Y, Ito H, Morishita R, Ogihara T. Potential of microvascular reperfusion with adjunctive pharmacological intervention: its impact on myocardial perfusion and functional outcomes in patients with acute myocardial infarction. Drugs. 2001;61:437-441.
  157. Aoki M, Nata T, Morishita R, Matsushita H, Nakagami H, Yamamoto K, Yamazaki K, Nakabayashi M, Ogihara T, Kaneda Y. Endothelial apoptosis induced by oxidative stress through activation of NFkB: anti-apoptotic effect of antioxidant agents on endothelial cells. Hypertension 2001;38:48-55
  158. Hayashi K, Morishita R, Nakagami H, Yoshimura S, Hara A, Matsumoto K, Nakamura T, Kaneda Y, Ogihara T, Sakai N. Gene therapy for preventing neuronal death using hepatocyte growth factor: in vivo gene transfer of HGF to subarachnoid space prevents delayed neuronal death in gerbil hippocampal CA1 neurons. Gene Therapy 2001;8:1167-1173
  159. Otomo T. Yamamoto S, Morishita R, Kaneda Y. EBV replicon vector system enhances transgene expression in vivo: applications to gene therapy for cancer. The Journal of Gene Medicine. 2001;3:345-352
  160. Sakaue G, Shimaoka M, Fukuoka T, Hiroi T, Inoue T, Hashimoto N, Sakaguchi T, Sawa Y, Morishita R, Kiyono H, Noguchi K, Mashimo T. NFkB decoy suppresses cytokine expression and thermal hyperalgesia in a rat neuropathic model. Somatosensory Systems, Pain. 2001;12:2079-2084
  161. Aoki M, Morishita R, Hayashi SI, Jo N, Matsumoto K, Nakamaura T, Kaneda Y, Ogihara T. Inhibition of neointimal formation after balloon injury by cilostazol, accompanied by improvement of endothelial dysfunction and induction of hepatocyte growth factor in rat diabetes model. Diabetologia 2001;44:1034-1042
  162. Taniyama Y, Morishita R, Hiraoka K, Aoki M, Nakagami H, Yamasaki K, Matsumoto K, Nakamura T, Kaneda Y, Ogihara T. Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat diabetic hind limb ischemia model: molecular mechanisms of delayed angiogenesis in diabetes. Circulation 2001;104:2344-2350.
  163. Yokoseki O, Suzuki Ji J, Kitabayashi H, Watanabe N, Wada Y, Aoki M, Morishita R, Kaneda Y, Ogihara T, Futamatsu H, Kobayashi Y, Isobe M. cis Element Decoy Against Nuclear Factor-kappaB Attenuates Development of Experimental Autoimmune Myocarditis in Rats. Circ Res. 2001;89:899-906.
  164. Ueno T, Sawa Y, Kitagawa-Sakakida S, Nishimura M, Morishita R, Kaneda Y, Kohmura E, Yoshimine T, Matsuda H. Nuclear factor-kappaB decoy attenuates neuronal damage after global brain ischemia: A future strategy for brain protection during circulatory arrest. J Thorac Cardiovasc Surg. 2001;122:720-727.
  165. Yoshimura S, Morishita R, Hayashi K, Yamamoto K, Nakagami H, Kaneda Y, Sakai N, Ogihara T. Inhibition of intimal hyperplasia after balloon injury in rat carotid artery model using cis-element "decoy" of nuclear factor-kB binding site as a novel molecular strategy. Gene Therapy 2001;8:1635-1642
  166. Miyata T, Yamamoto S, Sakamoto K, Morishita R, Kaneda Y. Novel immunotherapy for peritoneal dissemination of murine colon cancer with macrophage inflammatory protein-1b mediated by a tumor-specific vector, HVJ catinonic liposomes. Cancer Gene Therapy 2001;8:852-860
  167. Tsuchikane E, Nakamura T, Yamasaki K, Kobayashi T, Ptsuji S, Kobayashi T, Morishita R, Awata N. Correlation between serum hepatocyte growth factor level and percutaneous coronary balloon angioplasty: an alternative mechanisms of reduction in restenosis with cilostazol. International Journal of Angiology. 2001;10:270-274.
  168. Namiki M, Kawashima S, Yamashita T, Ozaki M, Hirase T, Ishida T, Inoue N, Hirata Ki K, Matsukawa A, Morishita R, Kaneda Y, Yokoyama M. Local overexpression of monocyte chemoattractant protein-1 at vessel wall induces infiltration of macrophages and formation of atherosclerotic lesion: synergism with hypercholesterolemia. Arterioscler Thromb Vasc Biol. 2002;22:115-120.
  169. Yasumoto H, Kim S, Zhan Y, Miyazaki H, Hoshiga M, Kaneda Y, Morishita R, Iwao H. Dominant negative c-Jun gene transfer inhibits vascular smooth muscle cell proliferation and neointimal hyperplasia in rats. Gene Therapy 2002;8:1682-1689.
  170. Taniyama Y, Tachibana K, Hiraoka K, Namba T, Yamasaki K, Hashiya N, Aoki M, Ogihara T, Kaneda Y, Morishita R. Local delivery of plasmid DNA into rat carotid artery using ultrasound. Circulation 2002;105:1233-1239.
  171. Morishita R, Sakaki M, Yamamoto K, Iguchi S, Aoki M, Yamasaki K, Matsumoto K, Nakamura T, Lawn R, Ogihara T, Kaneda Y. Impairment of collateral formation in Lp(a) transgenic mice: therapeutic angiogenesis induced by human hepatocyte growth factor gene. Circulation 2002;105:1491-1496
  172. Taniyama Y, Tachibana K, Hiraoka K, Aoki M, Yamamoto S, Matsumoto K, Nakamura T, Ogihara T, Kaneda Y, Morishita R. Development of safe and efficient novel non-viral gene transfer using ultrasound: enhancement of transfection efficiency of naked plasmid DNA in skeletal muscle. Gene Therapy 2002;9:372-380.
  173. Nakamura T, Morishita R, Asai T, Tsuboniwa N, Aoki M, Sakonjo H, Yamasaki K, Hashiya N, Kaneda Y, Ogihara T. Molecular strategy using cis-element “decoy” of E2F binding site inhibits neointimal formation in porcine balloon-injured coronary artery model. Gene Therapy 2002;9:488-494
  174. Endoh M, Koibuchi N, Sato M, Morishita R, Kanzaki T, Murata Y, Kaneda Y. Fetal gene transfer by intrauterine injection with microbubble-enhanced ultrasound. Molecular Therapy 2002;5:501-508
  175. Mori M, Nakagami H, Morishita R, Mitsuda N, Yamamoto K, Yoshimura S, Ohkubo N, Sato N, Ogihara T, Kaneda Y. N1411 mutant presenilin-2 gene enhances neuronal cell death and decreases bcl-2 expression. Life Sciences 2002;70:2567-2580.
  176. Yoshimura S, Morishita R, Hayashi K, Kokuzawa J, Aoki M, Matsumoto K, Nakamura T, Ogihara T, Kaneda Y, Sakai N. Gene transfer of hepatocyte growth factor to subarachnoid space in cerebral hypoperfusion model. Hypertension 2002;39:1028-1034
  177. Komai N, Ohishi M, Morishita R, Moriguchi A, Kaibe M, Matsumoto K, Rakugi H, Higaki J, Ogihara T. Serum hepatocyte growth factor concentration is correlated with the forearm vasodilator response in hypertensive patients. American Journal of Hypertension 2002;15:499-506
  178. Ahn JD, Morishita R, Kaneda Y, Lee SJ, Kwon KY, Choi SY, Lee KU, Park JY, Moon IJ, Park JG, Yoshizumi M, Ouchi Y, Lee IK. Inhibitory Effects of Novel AP-1 Decoy Oligodeoxynucleotides on Vascular Smooth Muscle Cell Proliferation In Vitro and Neointimal Formation In Vivo. Circ Res. 2002;90:1325-1332.
  179. Tomita N, Morishita R, Koike H, Hashizume M, Notake M, Fujitani B, Kaneda Y, Horiuchi M, Ogihara T. Therapeutic approach to familial hypercholesterolemia by HVJ-liposomes in LDL receptor knockout mouse. International Journal of Molecular Medicine 2002;10:137-143
  180. Taniyama Y, Morishita R, Aoki M, Hiraoka K, Yamasaki K, Hashiya N, Matasumoto K, Nakamura T, Kaneda Y, Ogihara T. Angiogensis and anti-fibrotic action by hepatocyte growth factor in cardiomyopathic hamster. Hypertension 2002;40:47-53
  181. Nakagami H, Morishita R, Yamamoto K, Taniyama Y, Aoki M, Yamasaki K, Matasumoto K, Nakamura T, Kaneda Y, Ogihara T. Hepatocyte growth factor (HGF) prevents endothelial cell death through inhibition of bax translocation from cytosol to mitochondrial membrane. Diabetes 2002;51:2604-2611.
  182. Kaneda Y, Nakajima T, Nishikawa T, Yamamoto S, Ikegami H, Suzuki N, Nakamura H, Morishita R, Kotani T. Hemagglutinating Virus of Japan (HVJ) envelope vector as a versatile gene delivery system Molecular Therapy 2002;6:219-226.
  183. Tomita N, Morishita R, Yamamoto K, Higaki J, Dzau VJ, Ogihara T, Kaneda Y. Targeted gene therapy for rat glomerulonephritis using HVJ-immunoliposomes. Journal of Gene Medicine. 2002;4:527-535
  184. Nakamura H, Aoki M, Tamai K, Oishi M, Ogihara T, Kaneda Y, Morishita R. Prevention and regression of atopic dermatitis by ointment containing NF-kB decoy oligodeoxynucleotides in NC/Nga atopic mouse model. Gene Therapy 2002;9:1221-1229
  185. Komai N, Morishita R, Yamada S, Ohishi M, Iguchi S, Aoki M, Sakaki M, Sakurabayashi I, Higaki J, Ogihara T. Mitogenic activity of oxidized lipoprotein (a) on human vascular smooth muscle cells. Hypertension 2002;40:310-314
  186. Nakanishi K, Uenoyama M, Tomita N, Morishita R, Kaneda Y, Ogihara T, Matsumoto K, Nakamura T, Maruta A, Matsuyama S, Kawai T, Aurues T, Hayashi T, Ikeda T. Gene transfer of human hepatocyte growth factor into rat skin wounds mediated by liposomes coated with the sendai virus (hemagglutinating virus of Japan). American Journal of Pathology. 2002;161:1761-1772.
  187. Matsumoto K, Morishita R, Tomita N, Moriguchi A, Yamasaki K, Aoki M, Matasumoto K, Nakamura T, Higaki J, Ogihara T. Impaired endothelial dysfunction in diabetes mellitus rats was restored by oral administration of prostaglandin I2 analogue, accompanied by increase in vascular hepatocyte growth factor. Journal of Endocrinology 2002;175:217-223
  188. Morishita R, Gibbons GH, Kaneda Y, Zhang L, Ogihara T, Dzau VJ. Apolipoprotein E-deficient mice created by systemic administration of antisense oligodeoxynucleotides: a new model for lipoprotein metabolism studies. Journal of Endocrinology 2002;175:475-485
  189. Ahn JD, Morishita R, Kaneda Y, Kim HS, Chang YC, Lee KU, Park JY, Lee HW, Kim YH, Lee IK. Novel E2F decoy oligodeoxynucleotides inhibit in vitro vascular smooth muscle cell proliferation and in vivo neointimal hyperplasia. Gene Ther. 2002;9:1682-1692.
  190. Tsukioka K, Suzuki J, Fujimori M, Wada Y, Yamaura K, Ito K, Morishita R, Kaneda Y, Isobe M, Amano J. Expression of matrix metalloproteinases in cardiac allograft vasculopathy and its attenuation by anti MMP-2 ribozyme gene transfection. Cardiovasc Res. 2002;56:472-478.
  191. Jo N, Ogata N, Aoki M, Otsuji T, Morishita R, Kaneda Y, Matsumura M. Effective transfection of a cis element "decoy" of the nuclear factor-kappaB binding site into the experimental choroidal neovascularization. Curr Eye Res. 2002;24:465-473.
  192. Shimamura M, Morishita R, Endoh M, Oshima K, Aoki M, Waguri S, Uchiyama Y, Kaneda Y. HVJ-envelope vector for gene transfer into central nervous system. Biochemical Biophysics Research Communications 2003;300:464-471
  193. Azuma H, Tomita N, Kaneda Y, Koike H, Ogihara T, Katsuoka Y, Morishita R. Transfection of NFkB decoy oligodeoxynucleotides using efficient ultrasound-mediated gene transfer into donor kidneys prolonged survival of rat renal allografts. Gene Therapy 2003;10:415-425
  194. Yamasaki K, Asai T, Shimizu M, Aoki M, Hashiya N, Sakonjo H, Makino H, Kaneda Y, Ogihara T, Morishita R. Inhibition of NFkB activation using cis-element "decoy" of NFkB binding site reduces neointimal formation in porcine balloon-injured coronary artery model. Gene Therapy 2003;10:356-364.
  195. Koike H, Morishita R, Iguchi S, Aoki M, Matsumoto K, Nakamura T, Yokoyama C, Tanabe T, Ogihara T, Kaneda Y. Enhanced angiogenesis and improvement of neuropathy by co-transfection of human hepatocyte growth factor and prostacyclin synthase gene. The FASEB Journal 2003;17:779-781
  196. Sekiguchi K, Yasuzumi F, Morishita R. Exogenous expression of hepatocyte growth factor (HGF) in rat striatum by naked plasmid DNA. Neuroscience Research 2003;45:173-180
  197. Nakabayashi M, Morishita R, Nakagami H, Kuba K, Matasumoto K, Nakamura T, Kamei M, Tano Y, Kaneda Y. HGF/NK4 inhibited VEGF-induced angiogenesis in in vitro cultured endothelial cells and in vivo rabbit model. Diabetologia 2003;46:115-123
  198. Matsumoto K, Morishita R, Tomita N, Moriguchi A, Komai N, Aoki M, Matasumoto K, Nakamura T, Higaki J, Ogihara T. Improvement of endothelial dysfunction by angiotensin II blockade, accompanied by induction of vascular hepatocyte growth factor system in diabetic spontaneously hypertensive rats. Heart & Vessels 2003;18:18-25
  199. Yamamoto S, Yamano T, Tanaka M, Hoon D.S.B., Takao S, Morishita R, Aikou T, Kaneda Y. A novel combination of suicide gene therapy and histone deacetylase inhibitor for treatment of malignant melanoma. Cancer Gene Therapy. 2003;10:179-186.
  200. Tomita N, Morishita R, Taniyama Y, Koike H, Aoki M, Shimizu H, Matsumoto K, Nakamura T, Kaneda Y, Ogihara T. Angiogenic property of hepatocyte growth factor is dependent on up-regulation of essential transcription factor for angiogenesis, ets-1. Circulation 2003;107:1411-1417
  201. Kato N, Nakanishi K, Nemoto K, Morishita R, Kaneda Y, Uenoyama M, Ikeda T, Fujikawa K. Efficient gene transfer from innervated muscle into rat peripheral and central nervous systems using a non-viral hemaggultinating virus of Japan (HVJ)-liposome method. Journal of Neurochemistry 2003;85:810-815.
  202. Ogushi I, Iimuro Y, Seki E, Son G, Hirano T, Hada T, Tsutsui H, Nakanishi K, Morishita R, Kaneda Y, Fujimoto J. Nuclear factor kappa B decoy oligodeoxynucleotides prevent endotoxin-induced fatal liver failure in a murine model. Hepatology. 2003;38:335-344
  203. Lan HY, Mu W, Tomita N, Morishita R, Yu XQ, Li JH, Zhu HJ, Huang XR, Johnson RJ. Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model. Journal of American Society of Nephrology 2003;14:1535-1548.
  204. Namba T, Koike H, Murakami K, Aoki M, Makino H, Hashiya N, Ogihara T, Kaneda Y, Kohno M, Morishita R. Angiogenesis induced by endothelial nitric oxide synthase gene through VEGF expression in rat hindlimb ischemia model. Circulation 2003;108:2250-2257
  205. Hiraoka K, Koike H, Yamamoto S, Tomita N, Yokoyama C, Tanabe T, Aikou T, Ogihara T, Kaneda Y, Morishita R. Enhanced therapeutic angiogenesis by co-transfection of prostacyclin synthase gene or optimization of intramuscular injection of naked plasmid DNA. Circulation 2003;108:2689-2696.
  206. Kokuzawa J, Yoshimura S, Kitajima H, Shinoda J, Kaku Y, Iwama T, Morishita R, Shimazaki T, Okano H, Kunisada T, Sakai N. Hepatocyte growth factor promotes proliferation and neuronal differentiation of neural stem cells from mouse embryos. Mol Cell Neurosci. 2003;24:190-197.
  207. Wada Y, Fujimori M, Suzuki J, Tsukioka K, Ito K, Sawa Y, Morishita R, Kaneda Y, Isobe M, Amano J. Egr-1 in vascular smooth muscle cell proliferation in response to allo-antigen. J Surg Res. 2003;115:294-302.
  208. Nakashima H, Aoki M, Miyake T, Kawasaki T, Iwai M, Jo N, Oishi M, Kataoka K, Ohigi S, Ogihara T, Kaneda Y, Morishita R. Inhibition of experimental abdominal aortic aneurysm in the rat by use of decoy oligodeoxynucleotides suppressing activity of NFkB and ets transcription factors. Circulation 2004;109:132-138
  209. Ohtani K, Egashira K, Usui M, Ishibashi M, Hiasa KI, Zhao Q, Aoki M, Kaneda Y, Morishita R, Takashita A. Inhibition of neointimal hyperplasia after balloon injury by cis-element “decoy” of early growth response gene-1 in hypercholesterolemic rabbits. Gene Therapy 2004;11:126-132.
  210. Namiki M, Kawashima S, Yamashita T, Ozaki M, Sakoda T, Inoue N, Hirata K, Morishita R, Kaneda Y, Yokoyama M. Intramuscular gene transfer of interleukin-10 cDNA reduces atherosclerosis in apolipoprotein E-knockout mice. Atherosclerosis. 2004;172:21-29.
  211. Shimamura M, Sato N, Oshima K, Aoki M, Kurinami H, Waguri S, Uchiyama Y, Ogihara T, Kaneda Y, Morishita R. A novel therapeutic strategy to treat brain ischemia: over-expression of hepatocyte growth factor gene reduced ischemic injury without cerebral edema in rat model. Circulation 2004;109:424-431
  212. Oshima K, Shimamura M, Mizuno S, Tamai K, Doi K, Morishita R, Nakamura T, Kubo T, Kaneda Y. Intrathecal injection of HVJ-E containing HGF gene to cerebrospinal fluid can prevent and ameliorate hearing impairment in rats. FASEB J. 2004;18:212-214.
  213. Matsuki A, Yamamoto S, Nakagami H, Aoki M, Tamai K, Matsumoto K, Nakamura T, Ogihara T, Kaneda Y, Morishita R. No influence of tumor growth by intramuscular injection of hepatocyte growth factor plasmid DNA: safety evaluation of therapeutic angiogenesis gene therapy in mice. Biochemical Biophysical Research Communications. 2004;315:59-65
  214. Makino H, Aoki M, Hashiya N, Yamasaki K, Hiraoka K, Shimizu H, Azuma J, Kurinami H, Ogihara T, Morishita R. Increase in peripheral blood flow by intravenous administration of prostaglandin E1 in patients with peripheral arterial disease, accompanied by up-regulation of hepatocyte growth factor (HGF). Hypertension Research 2003;27:85-91
  215. Suzuki J, Ito H, Gotoh R, Morishita R, Egashira K, Isobe M. Initial clinical cases using an NF-kB decoy at the site of the coronary stenting for prevention of restenosis. Circulation Journal 2004;68:270-271
  216. Koibuchi N, Kaneda Y, Taniyama Y, Matsumoto K, Nakamura T, Ogihara T, Morishita R. Essential role of HGF (hepatocyte growth factor) in blood formation in Xenopus. Blood 2004;103:3320-3325
  217. Hashiya N, Aoki M, Tachibana K, Taniyama Y, Yamasaki K, Hiraoka K, Makino H, Kaneda Y, Ogihara T, Morishita R. Local delivery of E2F decoy oligodeoxynucleotides using ultrasound with microbubble agent (Optison) inhibits intimal hyperplasia after balloon injury in rat carotid artery model. Biochemical Biophysical Research Communications. 2004;317:508-514.
  218. Nakagami H, Morishita R, Nishikawa T, Shimizu H, Iguchi S, Matsumoto K, Nakamura T, Kaneda Y, Ogihara T. Anti-apoptotic action of bag-1 was not related to HGF receptor, c-met, in endothelial cells. Hypertension Research 2004;27:359-365
  219. Wada Y, Fujimori M, Suzuki J, Tsukioka K, Ito K, Sawa Y, Morishita R, Kaneda Y, Isobe M, Amano J. Egr-1 in vascular smooth muscle cell proliferation in response to allo-antigen. Journal of Surgical Research. 2004;115:293-302.
  220. Hashiya N, Jo N, Aoki M, Matsumoto K, Nakamura K, Sato Y, Ogata N, Ogihara T, Kaneda Y, Morishita R. In vivo evidence of angiogenesis induced by transcription factor, ets-1: ets-1 is located upstream of angiogenesis cascade. Circulation 2004;109:3035-3041
  221. Morishita R, Aoki M, Hashiya N, Makino H, Yamasaki K, Azuma J, Sawa Y, Matsuda H, Kaneda Y, Ogihara T. Safety evaluation of clinical gene therapy using hepatocyte growth factor to treat peripheral arterial disease by therapeutic angiogenesis. Hypertension 2004;44:203-209
  222. Yamamoto K, Tomita N, Yoshimura S, Nakagami H, Taniyama Y, Yamasaki K, Ogihara T, Morishita R. Hypoxia-induced renal epithelial cell death thourgh caspase-dependent pathway: role of bcl-2, bcl-xL and bax in tubular injury. International Journal of Molecular Medicine. 2004;14:633-640.
  223. Yamaura K, Ito K, Tsukioka K, Wada Y, Makiuchi A, Sakaguchi M, Akashima T, Fujimoto M, Sawa Y, Morishita R, Matsumoto K, Nakamura T, Suzuki J, Amano J, Isobe M. Suppression of acute and chronic rejection by hepatocyte growth factor in a murine model of cardiac transplantation: induction of tolerance and prevention of cardiac allograft vasculopathy. Circulation 2004;110:1650-1657.
  224. Katsuragi N, Morishita R, Nakamura N, Ochiai T, Taniayama Y, Hasegawa Y, Kawashima K, Kaneda Y, Ogihara T, Sugimura K. Periostin as a novel factor responsible for ventricular dilation. Circulation 2004;110:1806-1813
  225. Shimamura M, Sato N, Taniyama Y, Yamamoto S, Endoh M, Kurinami H, Aoki M, Ogihara T, Kaneda Y, Morishita R. Development of efficient plasmid DNA transfer into adult rat central nervous system using microbubble-enhanced ultrasound. Gene Therapy 2004;11:1532-1539
  226. Hiraoka K, Yamamoto S, Otsuru S, Nakai S, Tamai K, Morishita R, Ogihara T, Kaneda Y. Enhanced tumor-specific long-term immunity of Hemagglutinating Virus of Japan-mediated dendritic cell-tumor fused cell vaccination by coadministration with CpG oligodeoxynucleotides. Journal of Immunology 2004;173:4297-4307.
  227. Yamasaki K, Aoki M, Makino H, Hashiya N, Shimizu H, Ohishi M, Ogihara T, Morishita R. Effect of nifedipine on endothelial function in normotensive smokers: potential contribution of increase in circulating hepatocyte growth factor. Journal of Human Hypertension 2004;28:701-705
  228. Powell RJ, Dormandy J, Simons M, Morishita R, Annex BH. Therapeutic angiogenesis for critical LIMB ischemia: design of the haptocyte growth factor therapeutic angiogenesis clinical trial. Vascular Medicine 2004;9:1-6
  229. Tomita N, Kim JY, Gibbons GH, Zhang L, Kaneda Y, Stahl RA, Ogborn M, Venderville B, Morishita R, Baran D, Dzau VJ. Gene therapy with an E2F transcription factor decoy inhibits cell cycle progression in rat anti-Thy 1 glomerulonephritis. Int J Mol Med. 2004;13:629-636
  230. Ahn JD, Morishita R, Kaneda Y, Kim HJ, Kim YD, Lee HJ, Lee KU, Park JY, Kim YH, Park KK, Chang YC, Yoon KH, Kwon HS, Park KG, Lee IK. Transcription factor decoy for AP-1 reduces mesangial cell proliferation and extracellular matrix production in vitro and in vivo. Gene Ther. 2004;11:916-923.
  231. Koike H, Tomita N, Azuma H, Taniyama Y, Yamasaki K, Kunugiza Y, Tachibana K, Ogihara T, Morishita R. An efficient gene transfer method mediated by ultrasound and microbubbles into the kidney. Journal of Gene Medicine 2005;7:108-116.
  232. Kato N, Nemoto K, Nakanishi K, Morishita R, Kaneda Y, Uenoyama M, Ikeda T, Fujikawa K. Nonviral gene transfer of human hepatocyte growth factor improves streptozotocin-induced diabetic neuropathy in rats. Diabetes. 2005;54:846-854.
  233. Miwa K, Nakashima H, Aoki M, Miyake T, Kawasaki T, Iwai M, Oishi M, Kataoka K, Ohigi S, Ogihara T, Kaneda Y, Morishita R. Inhibition of ets, an essential transcription factor for angiogenesis, to prevent the development of abdominal aortic aneurysm in a rat model. Gene Therapy 2005;12:1109-1118.
  234. Makino H, Aoki M, Hashiya N, Yamasaki K, Shimizu H, Ogihara T, Morishita R. A calcium channel blocker, benidipine, improves forearm reactive hyperemia in patients with essential hypertension. Blood Pressure Suppl. 2005;1:39-44.
  235. Yumoto A, Fukushima Kusano K, Nakamura K, Hashimoto K, Aoki M, Morishita R, Kaneda Y, Ohe T. Hepatocyte growth factor gene therapy reduces ventricular arrhythmia in animal models of myocardial ischemia. Acta Med Okayama. 2005;59:73-78.
  236. Kato N, Nemoto K, Nakanishi K, Morishita R, Kaneda Y, Uenoyama M, Ikeda T, Fujikawa K. Nonviral HVJ (hemagglutinating virus of Japan) liposome-mediated retrograde gene transfer of human hepatocyte growth factor into rat nervous system promotes functional and histological recovery of the crushed nerve. Neurosci Res. 2005;52:299-310.
  237. Tashiro H, Aoki M, Isobe M, Hashiya N, Makino H, Kaneda Y, Ogihara T, Morishita R. Development of novel method of non-viral efficient fene transfer into neonatal cardiac myocytes. Journal of Molecular and Cellular Cardiology 2005;39:503-509
  238. Morishita N, Nakagami H, Morishita R, Takeda S, Mishima F, Tarazono B, Nishijima S, Kaneda Y, Tanaka N. Magnetic nanoparticles with surface modification enhanced gene delivery of HVJ-E vector. Biochemical Biophysical Research Communications 2005;334:1121-1126.
  239. Taniyama Y, Kurinami H, Tanaka H, Takami T, Ogihara T, Tohyama M, Kaneda Y, Morishita R. Gene transfer into adult rat spinal cord using naked plasmid DNA and ultrasound microbubbles. Journal of Gene Medicine 2005;7:1468-1474
  240. Nakagami H, Maeda K, Morishita R, Iguchi S, Nishikawa T, Takami Y, Kikuchi Y, Saito Y,. Tamai K, Ogihara T, Kaneda Y. Novel autologous cell therapy in ischemic limb disease through growth factor secretion by cultured adipose tissue-derived stromal cells. Artrioscleros, Thrombosis and Vascular Biology 2005;25:2542-2547.
  241. Inagaki H, Suzuki J, Ogawa M, Taniyama Y, Morishita R, Isobe M. Ultrasound-microbubble mediated NF-kB decoy transfection attenuates neointimal formation after arterial injury in mice. Journal of Vascular Research 2006;43:12-18
  242. Kim YD, Park KG, Morishita R, Kaneda Y, Kim SY, Song DK, Kim HS, Nam CW, Lee HC, Lee KU, Park JY, Kim BW, Kim JG, Lee IK. Liver-directed gene therapy of diabetic rats using an HVJ-E vector containing EBV plasmids expressing insulin and GLUT 2 transporter. Gene Therapy 2006;13:216-224.
  243. Miyake T, Aoki M, Shiraya S, Kawasaki T, Oishi M, Kataoka K, Tanemoto K, Ogihara T, Kaneda Y, Morishita R. Prevention of aneurysms by simultaneous inhibition of NFκB and ets using chimeric decoy oligonucleotides in rabbit model. Gene Therapy 2006;13:695-704
  244. Shimamura M, Sato N, Waguri S, Uchiyama Y, Hayashi T, Iida H, Nakamura T, Ogihara T, Kaneda Y, Morishita R. Gene transfer of HGF gene improves learning and memory in the chronic stage of cerebral infarction. Hypertension 2006;47:742-751
  245. Koibuchi N, Taniyama Y, Nagao K, Ogihara T, Kaneda Y, Morishita R. The Effect of VEGF on blood vessels and blood cells during Xenopus development. Biochemical Biophysical Research Communications 2006;344:339-345
  246. Shimizu H, Nakagami H, Tsukamoto I, Morita S, Kunugiza Y, Tomita T, Yoshikawa H, Kaneda Y, Ogihara T, Morishita R. NFkB decoy oligodeoxynucleotides ameliorates osteoporosis through inhibition of activation and differentiation of osteoclasts. Gene Therapy 2006;13:933-941
  247. Nishikawa T, Nakagami H, Matsuki A, Maeda A, Yo CY, Harada T, Morishita R, Tamai K, Kaneda Y. Development of high throughput functional screening of therapeutic genes using HVJ-E vector. Human Gene Therapy 2006;17:470-475
  248. Sato N, Okochi M, Taniyama Y, Kurinami H, Shimamura H, Takeuchi D, Hamada H, Fukumori A, Kiyosue K, Taguchi T, Tanaka T, Miyasaki M, Takeda M, Ogihara T, Morishita R. Development of new screening system for Alzheimer Disease, in vitro Aβ sink assay, to identify dissociation of soluble Aβ from fibrils. Neurobiology of Disease 2006;22:487-495.
  249. Nakagami H, Nakagawa N, Takeya Y, Kashiwagi K, Ishida C, Hayashi S, Aoki M, Matsumoto K, Nakamura T, Ogihara T, Morishita R. A model of vasculogenesis from ES cells for vascular research and regenerative medicine. Hypertension 2006;48:112-119
  250. Kunugiza Y, Tomita N, Taniyama Y, Tomita T, Osako MK, Tamai K, Tanabe T, Kaneda Y, Yoshikawa H, Morishita R. Acceleration of wound healing by combined gene transfer of hepatocyte growth factor and prostacycline synthase with shima jet. Gene Therapy 2006;13:1143-1152
  251. Tomita T, Kunugiza Y, Tomita N, Takano H, Morishita R, Kaneda Y, Yoshikawa H. E2F decoy oligodeoxynucleotide ameliorates cartilage invasion by infiltrating synovium derived from rheumatoid arthritis. International Journal of Molecular Medicine 2006;18:257-265
  252. Azuma H, Taniyama Y, Takeya Y, Iekushi K, Aoki M, Dosaka N, Matsumoto K, Nakamura T, Ogihara T, Morishita R. Angiogenic and anti-fibrotic actions of hepatocyte growth factor improve cardiac dysfunction in porcine ischemic cardiomyopathy. Gene Therapy 2006;13:1206-1213.
  253. Saito Y, Nakagami H, Morishita R, Takami Y, Kikuchi Y, Hayashi H, Nishikawa T, Tamai K, Azuma N, Sasajima T, Kaneda Y. Transfection of human hepatocyte growth factor gene ameliorates secondary lymphedema via promotion of lymphangiogenesis. Circulation 2006;114:1177-1184
  254. Miyake T, Aoki M, Shiraya S, Tanemoto K, Ogihara T, Kaneda Y, Morishita R. Inhibitory effects of NFκB decoy oligodeoxynucleotides on neointimal hyperplasia in a rabbit vein graft model. Journal of Molecular and Cellular Cardiology 2006;41:431-440
  255. Shiraya S, Miwa K, Aoki M, Miyake T, Oishi M, Kataoka K, Ohgi S, Ogihara T, Kaneda Y, Morishita R. Hypertension accelerated experimental abdominal aortic aneurysm through up-regulation of transcription factors, NFkB and Ets. Hypertension 2006;48:628-636
  256. Koike H, Ishida A, Shimamura M, Mizuno S, Nakamura T, Ogihara T, Kaneda Y, Morishita R. Prevention of onset of Parkinson's disease by in vivo gene transfer of human hepatocyte growth factor in rodent model: a model of gene therapy for Parkinson’s disease. Gene Therapy 2006;13:1639-1644
  257. Ohtani K, Egashira K, Nakano K, Zhao G, Funakoshi K, Ihara Y, Kimura S, Tominaga R, Morishita R, Sunagawa K. Stent-based local delivery of nuclear factor-kB decoy attenuates in-stent restenosis in hypercholesterolemic rabbits. Circulation 2006;114:2773-2779
  258. Kunugiza Y, Tomita T, Tomita N, Morishita R, Yoshikawa H. Inhibitory effect of ribbon-type NF-kappaB decoy oligodeoxynucleotides on osteoclast induction and activity in vitro and in vivo. Arthritis Research & Therapy. 2006;8:R103
  259. Tomita N, Yamasaki K, Izawa K, Kunugiza Y, Osako MK, Ogihara T, Morishita R. Improvement of organ damage by a non-depressor dose of imidapril in diabetic spontaneously hypertensive rats. International Journal of Molecular Medicine. 2007;19:571-579
  260. Wakayama K, Shimamura M, Sata M, Sato N, Kawakami K, Fukuda H, Tomimatsu T, Ogihara T, Morishita R. Quantitative measurement of neurological deficit after mild (30 min) transient middle cerebral artery occlusion in rats. Brain Research Brain Research 2007;1130:181-187.
  261. Shimamura M, Sato N, Sata M, Wakayama K, Ogihara T, Morishita R. Expression of hepatocyte growth factor and c-met after spinal cord injury in rats. Brain Research 2007;1151:188-194
  262. Iekushi K, Taniyama Y, Azuma J, Katsuragi N, Dosaka N, Sanada F, Koibuchi N, Nagao K, Ogihara T, Morishita R. Novel mechanisms of the beneficial effect of an angiotensin receptor blocker, valsartan, on the treatment of heart failure through the inhibition of anti-adhesion molecule, periostin. Hypertension 2007;49:1409-1414
  263. Osako MK, Tomita N, Nakagami H, Kunugiza Y, Yoshino M, Yuyama K, Tomita T, Yoshikawa H, Ogihara T, Morishita R. Increase in nuclease resistance and incorporation of NF-kB decoy oligodeoxynucleotides by modification of 3’-terminus. Journal of Gene Medicine 2007;9:812-819.
  264. Taniguchi H, Fujiwara Y, Doki Y, Sugita Y, Souma I, Miyata H, Takiguchi S, Yasuda T, Tomita N, Morishita R, Monden M. Gene therapy using ets-1 transcription factor decoy for peritoneal dissemination of gastric cancer. International Journal of Cancer 2007;121:1609-1617
  265. Takami Y, Nakagami H, Morishita R, Katsuya T, Cui TX, Ichikawa T, Saito Y, Hayash H, Kikuchi Y, Nishikawa T, Baba Y, Yasuda O, Rakugi H, Ogihara T, Kaneda Y. Ubiquitin carboxyl-terminal hydrolase L1, a novel deubiquitinating enzyme in the vasculature, attenuates NF-kB activation. Arteriosclerosis, Thrombosis, & Vascular Biology 2007;27:2184-2190
  266. Shimizu N, Azuma N, Nishikawa T, Hirata S, Morishita R, Kaneda Y, Sasajima T. Effect on vein graft intimal hyperplasia of nuclear factor-kB decoy transfection using the second generation of HVJ vector. Journal of Cardiovascular Surgery (Torino). 2007;48:463-470.
  267. Hayashi H, Nakagami H, Takami Y, Sato N, Saito Y, Nishikawa T, Mori M, Koriyama H, Tamai K, Morishita R, Kaneda Y. Involvement of gamma-secretase in postnatal angiogenesis. Biochemical Biophysical Research Communications 2007;363:584-590
  268. Shimamura M, Sato N, Sata M, Kurinami H, Takeuchi D, Wakayama K, Kawakami K, Hayashi T, Iida H, Morishita R. Delayed post-ischemic treatment with fluvastatin improved learning and memory deficit after stroke in rats. Stroke 2007;38:3251-3258
  269. Nakagawa A, Aoki M, Miyake T, Shiraya S, Nakamura T, Ogihara T, Kimata Y, Morishita R. Improvement of survival of skin flaps by combined gene transfer of hepatocyte growth factor and prostacycline synthase, Journal of Gene Medicine 2007;9:1087-1094
  270. Miyake T, Aoki M, Masaki H, Kawasaki T, Oishi M, Kataoka K, Ogihara T, Kaneda Y, Morishita R. Regression of abdominal aortic aneurysms by simultaneous inhibition of NFκB and ets in a rabbit model. Circulation Research 2007;101:1175-1184
  271. Aoki T, Kataoka H, Shimamura M, Nakagami H, Wakayama K, Moriwaki T, Ishibashi R, Nozaki K, Morishita R, Hashimoto N. NF-κB is a key mediator of cerebral aneurysm formation. Circulation 2007;116:2830-2840.
  272. Nagao K, Taniyama Y, Koibuchi N, Morishita R. Constitutive over-expression of VEGF results in reduced expression of Hand-1 during cardiac development in Xenopus. Biochemical Biophysical Research Communications 2007;359:431-437.
  273. Nakagami H, Kikuchi Y, Katsuya T, Morishita R, Akasaka H, Saitoh S, Rakugi H, Kaneda Y, Shimamoto K, Ogihara T. Gene polymorphism of myospryn (cardiomyopathy-associated 5) is associated with left ventricular wall thickness in patients with hypertension. Hypertension Research 2007;30:1239-1246.
  274. Azuma H, Tomita N, Sakamoto T, Kiyama S, Inamoto T, Takahara K, Kotake Y, Segawa N, Morishita R, Takahara S, Hayasaki H, Otsuki Y, Horie S, Tanigawa N, Katsuoka Y. Marked regression of liver metastasis Marked regression of liver metastasis by combined therapy of ultrasound-mediated NFkB-decoy transfer and transportal injection of paclitaxel, in mouse Int J Cancer. 2008;122:1645-1656.
  275. Tomita N, Yamasaki K, Izawa K, Kunugiza Y, Osako MK, Ogihara T, Morishita R. Inhibition of experimental abdominal aortic aneurysm progression by nifedipine. International Journal of Molecular Medicine 2008;21:239-244.
  276. Takeuchi D, Sato N, Shimamura M, Kurinami H, Takeda S, Shinohara M, Suzuki S, Kojima M, Ogihara T, Morishita R. Alleviation of Aβ-induced cognitive impairment by ultrasound-mediated gene transfer of HGF in mouse model. Gene Therapy 2008;15:561-571
  277. Kurinami H, Sato N, Shinohara M, Takeda S, Takeuchi D, Shimamura M, Ogihara T, Morishita R. Prevention of Aβ-induced memory impairment by fluvastatin through the loss of neuron decrease in Aβ accumulation and oxidative stress. International Journal of Molecular Medicine 2008;21:531-537.
  278. Nagao K, Taniyama Y, Kietzmann T, Doi T, Komuro I, Morishita R. HIF-1α signaling upstream of Nkx2.5 is required for development of heart morphology in Xenopus. Journal of Biological Chemistry 2008;283:11841-11849
  279. Saito Y, Nakagami H, Kuraoka M, Takami Y, Kikuchi Y, Hayashi H, Nishikawa T, Tamai K, Morishita R, Azuma N, Sasajima T, Kaneda Y. Cold shock domain protein A represses angiogenesis and lymphangiogenesis via inhibition of serum response element. Oncogene 2008;27:1821-1833
  280. Egashira K, Suzuki J, Ito H, Aoki M, Isobe M, Morishita R. Long-term Follow Up of Initial Clinical Cases With NF-kB Decoy Oligodeoxynucleotide Transfection at the Site of the Coronary Stenting. Journal of Gene Medicine 2008;10:805-809.
  281. Takeya Y, Makino H, Aoki, M, Miyake T, Ozaki K, Rakugi H, Ogihara T, Morishita R. In vivo evidence of enhancement of HGF-induced angiogenesis by fluvastatin. The Open Gene Therapy Journal 2008;1:1-6
  282. Powell RJ, Simons M, Mendersohn F, Daniel G, Henry T, Koga M, Morishita R, Annex B. Results of a double-blind placebo-controlled study to assess the safety and efficacy of intramuscular injection of HGF plasmid to improve limb perfusion in patients with critical limb ischemia (HGF-STAT Trial). Circulation 2008;118:58-65
  283. Shimizu H, Nakagami H, Osako MK, Hanayama R, Kunugiza Y, Kizawa T, Tomita T, Yoshikawa H, Ogihara T, Morishita R. Angiotensin II accelerates osteoporosis by activating osteoclasts. The FASEB Journal 2008 22: 2465-2475
  284. Nakagami H, Osako MK, Takami Y, Hanayama R, Koriyama H, Mori M, Hayashi H, Shimizu H, Morishita R. Differential response on vascular HGF concentration and lipid accumulation between telmisartan and losartan in ApoE-deficient mice. Molecular Medicine Reports 2008;1:657-661.
  285. Miyake T, Aoki M, Morishita R. Inhibition of anastomotic intimal hyperplasia using a chimeric decoy strategy against NFkB and E2F in a rabbit model. Cardiovascular Research 2008;79:706-714
  286. Takami Y, Nakagami H, Morishita R, Katsuya T, Hayashi H, Mori M, Koriyama H, Baba Y, Yasuda O, Rakugi H, Ogihara T, Kaneda Y. Potential role of CYLD (cylindromatosis) as a deubiquitinating enzyme in vascular cells. American Journal of Pathology. 2008;172:818-829
  287. Tsubouchi M, Morishita R, Tabata Y, Matsui S, Kawakami K. Critical issues for effective corroboration between academia and industry in the field of regenerative medicine in Japan. Regenerative Medicine 2008;3:497-504
  288. Wakayama K, Shimamura M, Sata M, Koibuchi N, Sato N, Morishita R. A novel model of cerebrovascularinjury in rats. Journal of Neuroscience Methods 2008;175:187-195
  289. Fujiwara Y, Shiraya S, Miyake T, Yamanaka S, Aoki M, Makino H, Nishimura M, Morishita R. Inhibition of development of experimental aortic abdominal aneurysm in a rat model by the angiotensin II receptor blocker valsaratan. International Journal of Molecular Medicine 2008;22:703-708
  290. Sanada F, Taniyama Y, Azuma J, Iekushi K, Dosaka N, Yokoi T, Oshita Y, Koibuchi N, Aizawa Y, Morishita R. Hepatocyte growth factor, but not vascular endothelial growth factor, attenuated angiotensin II-induced senescence and oxidative stress in monocytic endothelial progenitor cells by inhibiting PIP3 activity. Hypertension 2008;53:77-82
  291. Tsuchihara T, Ogata S, Nemoto K, Okabayashi T, Nakanishi K, Kato N, Morishita R, Kaneda Y, Uenoyama M, Suzuki S, Amako M, Kawai T, Arino H. Nonviral retrograde gene transfer of human hepatocyte growth factor improves neuropathic pain-related phenomena in rats. Molecular Therapy. 2009;17:42-50
  292. Suzuki J, Tezuka D, Morishita R, Isobe M. An Initial Case of Suppressed Restenosis with NF-kB Decoy Transfection After PCI. Journal of Gene Medicine 2009;11:89-91.
  293. Shiraya S, Aoki M, Miyake T, Ohgi S, Nishimura S, Ogihara T, Morishita R. Inhibition of development of experimental aortic abdominal aneurysm in rat model by atorvastatin through the inhibition of macrophage migration. Atherosclerosis 2009;202:34-40
  294. Tsukada Y, Hara K, Bando Y, Huang CC, Kousaka Y, Kawashima Y, Morishita R, Tsujimoto H. Particle size of control of poly(DL-lactide-co-glycodite) nanospheres for sterile application. International Journal of Pharmaceutics 2009;307:196-201.
  295. Hanayama R, Shimizu H, Nakagami H, Osako MK, Makino H, Kunugiza Y, Tomita T, Tsukamoto I, Yoshikawa H, Rakugi H, Morishita R. Fluvastatin improves osteoporosis in fructose-fed insulin resistant model rats through blockade of the classical mevalonate pathway and antioxidant action. International Journal of Molecular Medicine 2009;23:581-588.
  296. Nakagami H, Osako MK, Hanayama R, Koriyama H, Shimizu H, Morishita R. Vascular protective effects of ezetimibe in apoE-deficient mice. Atherosclerosis 2009;203:51-58
  297. Aoki T, Kataoka H, Ishibashi R, Nakagami H, Nozaki K, Morishita R, Hashimoto N. Pitavastatin suppresses formation and progression of cerebral aneurysms through inhibition of the nuclear factor kappaB pathway. Neurosurgery. 2009;64:357-365.
  298. Kimura S, Egashira K, Chen L, Nakano K, Iwata E, Miyagawa M, Tsujimoto J, Hara K, Morishita R, Sueishi K, Tominaga R, Sunagawa K. Nanoparticle-mediated delivery of nuclear factor kB decoy into lungs ameliorates monocrotaline-induced pulmonary arterial hypertension. Hypertension 2009;53:877-883.
  299. Takeda S, Sato N, Uchio-Yamada K, Sawada K, Kunieda T, Takeuchi D, Kurinami H, Shinohara M, Rakugi H, Morishita R. Elevation of Plasma β-amyloid Level by Glucose Loading in Alzheimer Mouse Models. Biochemical and Biophysical Research Communications 2009;385:193-197
  300. Takeda S, Sato N, Niisato K, Takeuchi D, Kurinami H, Shinohara M, Rakugi H, Kano M, Morishita R. Validation of Aβ1-40 administration into mouse cerebroventricles as an animal model for alzheimer disease. Brain Research 2009;1280:137-147.
  301. Mori M, Nakagami H, Koibuchi N, Miura K, Takami Y, Koriyama H, Hayashi H, Sabe H, Mochizuki N, Morishita R, Kaneda Y. Zyxin mediates actin fiber reorganization in epithelial-mesenchymal transition and contributes to endocardial morphogenesis. Molecular Biology & Cell. 2009;20:3115-3124.
  302. Hayashi H, Nakagami H, Takami Y, Koriyama H, Mori M, Tamai K, Sun J, Nagao K, Morishita R, Kaneda Y. FHL-2 suppresses VEGF-induced phosphatidylinositol 3-kinase/Akt activation via interaction with sphingosine kinase-1. Arteriosclerosis, Thrombosis, & Vascular Biology 2009;29:909-914
  303. Aoki T, Kataoka H, Ishibashi R, Nozaki K, Morishita R, Hashimoto N Reduced collagen biosynthesis is the hallmark of cerebral aneurysm. contribution of interleukin-1b and Nuclear Factor-kB. Arteriosclerosis, Thrombosis, & Vascular Biology 2009;29:1080-1086.
  304. Morishita R, Ishii J, Kasumi Y, Yamada S, Komai N, Ohishi M, Nomura M, Hishida H, Niihashi M, Mitsumata M. Association of serum oxidized lipoprotein(a) concentration with coronary artery disease: Potential role of oxidized Lipoprotein(a) in the vascular wall. Journal of Atherosclerosis and Thrombosis 2009;410-418
  305. Shimizu H, Nakagami H, Osako MK, Nakagami F, Kunugiza Y, Tomita T, Yoshikawa H, Rakugi H, Ogihara T, Morishita R. Prevention of Osteoporosis by Angiotensin Converting Enzyme Inhibitor in Spontaneous Hypertensive Rats. Hypertension Research 2009;32:786-790
  306. Hayashi S, Sato N, Yamamoto A, Ikegami Y, Nakajima S, Morishita R. Alzheimer disease associated peptide, amyloid β40 inhibits vascular regeneration with induction of endothelial autopsy. Arteriosclerosis, Thrombosis, & Vascular Biology 2009:29:1909-1915
  307. Kim MS, Kim MS, Lee CS, Hur J, Cho HJ, Jun SI, Kim TY, Lee SW, Suh JW, Park KW, Lee HY, Kang HJ, Lee DS, Koh GY, Nakagami H, Morishita R, Park YB, Kim HS. Priming with angiopoietin-1 augments the vasculogenic potential of the peripheral blood stem cells mobilized with granulocyte colony-stimulating factor through a novel tie2/ets-1 pathway. Circulation 2009;120:2240-2250
  308. Sanada F, Taniyama Y, Iekushi K, Azuma J, Dosaka N, Shimizu K, Kusunoki H, Koibuchi N, Aizawa Y, Morishita R. Negative action of HGF /c-Met system on angiotensin II signaling via ligand-dependent EGF receptor degradation mechanism in VSMC. Circulation Research 2009;105:667-675
  309. Takeda S, Sato N, Takeuchi D, Kurinami H, Shinohara M, Niisato K, Kano M, Ogihara T, Rakugi H, Morishita R. Angiotensin receptor blocker prevented β-Amyloid-induced cognitive impairment associated with recovery of neurovascular coupling. Hypertension 2009;54:1345-1352.
  310. Aoki T, Nishimura M, Kataoka H, Ishibashi R, Miyake T, Takagi Y, Morishita R, Hashimoto N. Role of angiotensin II type 1 receptor in cerebral aneurysm formation in rats. International Journal of Molecular Medicine 2009;24:353-359
  311. Shimizu H, Nakagami H, Morita S, Tsukamoto I, Osako MK, Nakagami F, Shimosato T, Minobe N, Morishita R. New treatment of periodontal diseases using NFkB decoy oligodeoxunuclotides via prevention of bone resorption and promotion of wound healing. Antioxidant & Redox Signal. 2009;11:2065-2075
  312. Tomita N, Yamasaki K, Osako MK, Komai N, Shimosato T, Morishita R. Combination therapy based on angiotensin receptor blocker, olmesartan, for vascular protection in SHR. Molecular Medicine Reports 2009;2:733-738.
  313. Nishikawa T, Nakagami H, Maeda A, Morishita R, Miyazaki N, Ogawa T, Tabata Y, Kikuchi Y, Hayashi H, Tatsu Y, Yumoto N, Tamai K, Tomono K, Kaneda Y. Development of novel antimicrobial peptide, AG-30, with angiogenic property. Journal of Cellular and Molecular Medicine. 2009;13:535-546
  314. Suzuki J, Ogawa M, Takayama K, Taniyama Y, Morishita R, Hirata Y, Nagai R, Isobe M. Ultrasound-microbubble mediated ICAM-1 siRNA transfection attenuates neointimal formation after arterial injury in mice. Journal of American College of Cardiology 2010;55:904-913.
  315. Koriyama H, Nakagami H, Katsuya T, Akasaka H, Saitoh S, Shimamoto K, Ogihara T, Kaneda Y, Morishita R, Rakugi H. Variation in OSBPL10 is associated with dyslipidemia. Hypertension Research 2010;33:511-514.
  316. Takeda S, Sato N, Ushio-Yamada K, Sawada K, Kunieda T, Kurinami H, Shinohara M, Fujisawa T, Rakugi H, Morishita R. Diabetes accelerated memory dysfunction via cerebrovascular inflammation and Aβ deposition in Alzheimer mouse model with diabetes. Proceeding of National Academy of Sciences USA 2010;107:7036-7041.
  317. Oshima S, Fujimoto S, Petrov A, Nakagami H, Haider N, Zhou J, Tahata N, Osako MK, Fujimoto A, Zhu J, Edwards DS, Narula N, Wong N, Chandrashekhar Y, Morishita R, Narula J. Effect of an antimicrobial agent on atherosclerotic plaque and metalloproteinase production: assessment by molecular imaging. Journal of American Colledge of Cardiology 2010;55:1240-1249.
  318. Shinohara M, Sato N, Kurinami H, Takeuchi D, Takeda S, Shimamura M, Yamashita T, Uchiyama Y, Rakugi H, Morishita R. Reduction of brain Abeta by fluvastatin, an HMG-CoA reductase inhibitor, through increase in degradation of APP-CTFs and Abeta clearance. Journal of Biological Chemistry. 2010;285:22091-22102
  319. Morimoto D, Tomita T, Kuroda S, Higuchi C, Kato S, Shiba T, Nakagami H, Morishita R, Yoshikawa H. Inorganic polyphosphate differentiates human mesenchymal stem cells into osteoblastic cells. Journal of Bone Mineral Metabolism. 2010;28:418-423
  320. Nakagami F, Nakagami H, Osako MK, Iwabayashi M, Taniyama Y, Shimizu H, Rakugi H, Morishita R. Estrogen attenuates vascular remodeling in Lp(a) transgenic mice. Atherosclerosis 2010;211:41-47
  321. Osako MK, Nakagami H, Koibuchi N, Shimizu H, Nakagami F, Koriyama H, Katsuya T, Rakugi H, Morishita R. Estrogen inhibits vascular calcification via vascular RANKL system: common mechanism of osteoporosis and vascular calcification. Circulation Research 2010;107:466-475
  322. Shigematsu H, Yasuda K, Iwai T, Sasajima T, Ishimaru S, Ohashi Y, Yamaguchi T, Ogihara T, Morishita R. Randomized, double-blind, placebo-controlled clinical trial of hepatocyte growth factor plasmid for critical limb ischemia. Gene Therapy. 2010;17:1152-1161
  323. Aoki T, Kataoka H, Nishimura M, Ishibashi R, Morishita R, Miyamoto S. Ets-1 promotes the progression of cerebral aneurysm by inducing the expression of MCP-1 in vascular smooth muscle cells. Gene Therapy 2010;17:1117-1123
  324. Iekushi K, Taniyama Y, Azuma J, Sanada F, Yokoi T, Koibuchi N, Kusunoki H, Okayama K, Rakugi H, Morishita R. Hepatocyte growth factor attenuates angiotensin II induced renal fibrosis through TGF-β1 suppression by anoikis of myofibroblasts. Journal of Hypertension 2010;28:2454-2461.
  325. Koriyama H, Nakagami H, Katsuya T, Sugimoto K, Yamashita H, Takami Y, Maeda S, Kubo M, Takahashi A, Nakamura Y, Ogihara T, Rakugi H, Kaneda Y, Morishita R. Identification of suggestive evidence of association with peripheral arterial disease at the OSBPL10 locus by genome-wide investigation in the Japanese population. Journal of Atherosclerosis and Thrombosis 2010;17:1054-1062.
  326. Sugimoto K, Katsuya T, Kamide K, Fujisawa T, Shimaoka I, Ohishi M, Morishita R, Ogihara T, Rakugi H. Promoter polymorphism of RGS2 gene is associated with change of blood pressure in subjects with antihypertensive treatment: the Azelnidipine and Temocapril in hypertensive patients with Type 2 diabetes STudy (ATTEST). International Journal of Hypertension 2010:196307
  327. Shimizu H, Nakagami H, Yasumasa N, Osako MK, Shimamura M, Miyake T, Nakagami F, Koriyama H, Rakugi H, Morishita R. Combination of thiazide diuretics and angiotensin receptor blockers synergistically attenuates osteoporosis in hypertensive rats. Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry 2010;10:115-122.
  328. Nakagami H, Osako MK, Nakagami F, Shimosato T, Minobe N, Moritani T, Shimamura M, Miyake T, Shimizu H, Takeya Y, Morishita R. Prevention and regression of non-alcoholic steatohepatitis (NASH) in a rat model by metabosartan, telmisartan. International Journal of Molecular Medicine. 2010;26:477-481.
  329. Tahara K, Samura S, Tsuji K, Yamamoto H, Tsukada Y, Bando Y, Tsujimoto H, Morishita R, Kawashima Y. Oral nuclear factor-kB decoy oligonucleotides delivery system with chitosan modified poly(D,L-lactide-co-glycolide) nanospheres for inflammatory bowel disease. Biomaterials 2011;32:870-878
  330. Miyake T, Aoki M, Osako MK, Shimamura M, Nakagami H, Morishita R. Development of ribbon-type decoy oligodeoxynucleotides (ODN): systemic administration of ribbon-type decoy ODN against NFκB and Ets binding sites prevented abdominal aortic aneurysm in rat model. Molecular Therapy 2011;19:181-187
  331. Ohno K, Amano Y, Kakuta H, Niimi T, Takakura S, Orita M, Miyata K, Sakashita H, Takeuchi M, Komuro I, Higaki J, Horiuchi M, Kim-Mitsuyama S, Mori Y, Morishita R, Yamagishi S. Unique “Delta Lock” Structure of Telmisartan is Involved in its Strongest Binding Affinity to Angiotensin II Type 1 Receptor. Biochemical and Biophysical Research Communications 2011;404:434-437
  332. Shioyama W, Nakaoka Y, Higuchi K, Minami Takashi, Taniyama Yoshiaki, Nishida Keigo, Kidoya H, Sonobe T, Naito H, Arita Y, Hashimoto T, Kuroda T, Fujio Y, Shirai M, Takakura N, Morishita R, Yamauchi-Takihara K, Kodama T, Hirano T, Mochizuki N, Komuro I. Docking Protein Gab1 is an Essential Component of Postnatal Angiogenesis After Ischemia via HGF/c-Met Signaling. Circulation Research. 2011;108:664-675
  333. Morishita R, Makino H, Aoki M, Hashiya N, Yamasaki K, Azuma J, Taniyama Y, Sawa Y, Kaneda Y, Ogihara T. Phase I/IIa Clinical Trial of Therapeutic Angiogenesis Using Hepatocyte Growth Factor Gene Transfer to Treat Critical Limb Ischemia. Arteriosclerosis, Thrombosis, & Vascular Biology. 2011;31:713-720
  334. Shigematsu H, Yasuda K, Sasajima T, Takano T, Miyata T, Ohta T, Tanemoto K, Obitsu Y, Iwai T, Ozaki S, Ogihara T, Morishita R. Transfection of human HGF plasmid DNA improves limb salvage in Buerger's disease patients with critical limb ischemia. International Angiology. 2011;30:140-149.
  335. Kyutoku M, Taniyama Y, Katsuragi N, Shimizu H, Kunugiza Y, Iekushi K, Koibuchi N, Sanada F, Oshita Y, Morishita R. Role of periostin in cancer progression and metastasis: Inhibition of breast cancer progression and metastasis by anti-periostin antibody in a murine model. International Journal of Molecular Medicine 2011;28:181-186
  336. Takeda S, Sato N, Ikimura K, Nishio H, Rakugi H, Morishita R. Novel Microdialysis Method to Assess Neuropeptides and Large Molecules in Free-moving Mouse. Neuroscience 2011;186:110-119
  337. Iekushi K, Taniyama Y, Azuma J, Sanada F, Kusunoki H, Okayama K, Koibuchi N, Iwabayashi M, Rakugi H, Morishita R. Hepatocyte Growth Factor Attenuates TGF-β-Angiotensin II Crosstalk Through the Inhibition of PTEN/Akt Pathway. Hypertension 2011;58:190-196
  338. Shimamura M, Nakagami H, Shimosato T, Moritani T, Nakagami F, Osako MK, Miyake T, Koriyama H, Shimizu H, Morishita R. Improvement of Endothelial Dysfunction, Abnormal Lipid Profile, Proteinuria, and Liver Dysfunction by Irbesartan in Zucker Diabetic Fatty Rats Independent of Glucose and Insulin Levels. Experimental and Therapeutic Medicine 2011;2: 957-961
  339. Saito Y, Nakagami H, Azuma N, Hirata S, Sanada F, Taniyama Y, Morishita R, Kaneda Y, Sasajima T. Critical Roles of Cold Shock Domain Protein A as an Endogenous Angiogenesis Inhibitor in Skeletal Muscle. Antioxidants & Redox Signaling 2011;15:2109-2020
  340. Aoki T, Nishimura M, Matsuoka T, Yamamoto K, Furuyashiki T, Kataoka H, Kitaoka S, Ishibashi R, Ishibazawa A, Miyamoto S, Morishita R, Ando J, Hashimoto N, Nozaki K, Narumiya S. PGE2-EP2 signaling in endothelium is activated to hemodynamic stress and induces cerebral aneurysm through an amplifying loop via NF-κB. Short running title; PGE2- EP2 induces cerebral aneurysm via NF-κB. British Journal of Pharmacology 2011;163:1237-1249
  341. Nakagami H, Nishikawa T, Tamura N, Maeda A, Hibino H, Mochizuki M, Shimosato T, Moriya T, Morishita R, Tamai K, Tomono K, Kaneda Y. Modification of a Novel Angiogenic Peptide, AG30, for the Development of Novel Therapeutic Agents. Journal of Cellular and Molecular Medicine 2011. doi: 10.1111/j.1582-4934
  342. Nakagami H, Shimamura M, Miyake T, Shimosato T, Minobe N, Moritani T, Osako MK, Nakagami F, Koriyama H, Kyutoku M, Shimizu H, Katsuya T, Morishita R. Nifedipine prevents hepatic fibrosis in a non-alcoholic steatohepatitis (NASH) model induced by an L-methionine- and choline-deficient (MCA) diet. Molecular Medicine Reports 2012;5:37-40
  343. Shimizu H, Nakagami H, Yasumasa N, Osako MK, Kyutoku M, Koriyama H, Nakagami F, Shimamura M, Rakugi H, Morishita R. Cilnidipine, but not amlodipine, ameliorates osteoporosis in ovariectomized hypertensive rats through inhibition of N-type calcium channel. Hypertension Research 2012;35:77-81
  344. Kusunoki H, Taniyama Y, Azuma J, Iekushi K, Sanada F, Otsu R, Iwabayashi M, Okayama K, Rakugi H, Morishita R. Telmisartan Exerts Renoprotective Actions via PPARγ/HGF Pathway Independent of Angiotensin II Type 1 Receptor Blockade. Hypertension 2012;59:308-316
  345. Morishita R, Itakura H, Nakaya N, Yoshida M, Odawara M, Ichihara A, Muzuno K. Risk Factors on Cardiovascular Events in the Japanese Patients Treated with Fluvastatin from LEM study. Current Vascular Phamacology 2012;10:178-186
  346. Nakagami H, Osako MK, Yasumasa N, Shimamura M, Kyutoku M, Nakagami F, Koriyama H, Tomioka H, Katsuya T, Morishita R. Pitavastatin Improves Endothelial Function and Glucose Metabolism in Ovariectomized Mice. Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry 2012;12:29-33
  347. Suzuki J, Tezuka D, Morishita R, Isobe M. Eight-Year Follow-Up of an Initial Case with NF-kB Decoy Oligodeoxynucleotide Transfection After Coronary Stent Implantation. Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry 2012;12:40-42.
  348. Okayama K, Azuma J, Dosaka N, Iekushi K, Sanada F, Kusunoki H, Iwabayashi M, Rakugi H, Taniyama Y, Morishita R. Hepatocyte Growth Factor Reduces Cardiac Fibrosis by Inhibiting Endothelial-mesenchymal Transition. Hypertension. 2012;59:958-965.
  349. Iwabayashi M, Taniyama Y, Sanada F, Azuma J, Iekushi K, Kusunoki H, Amarnath Chatterjee, Okayama K, Rakugi H, Morishita R. Role of Serotoin in Angiogenesis: Induction of Angiogenesis via Endothelial 5-HT1B/Akt/eNOS Pathway by Sarpogrelate in Diabetic Mice. Atherosclerosis 2012;220:337-342
  350. Shimamura M, Taniyama Y, Katsuragi N, Koibuchi N, Kyutoku M, Sato N, Allahtavakoli M, Wakayama K, Nakagami H, Morishita R. Role of Central Nervous System Periostin in Cerebral Ischemia. Stroke 2012;43:1108-1114
  351. Yokoi T, Azuma J, Nakade Y, Sanada F, Iekushi K, Yoshika M, Masuda M, Komiyama Y, Taniyama Y, Masaki H, Morishita R, Takahashi H. Comparison between Two Calcium Antagonists: Blood Pressure Reduction and Renal Effects in Hypertensive Patients with Type 2 Diabetes. Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry 2012;12:152-159
  352. Kaga T, Kawano H, Sakaguchi M, Nakazawa T, Taniyama Y, Morishita R. HGF (Hepatocyte growth factor) stimulated angiogenesis without inflammation: Differential actions between HGF, VEGF (vascular endothelial growth factor) and bFGF (basic fibroblast growth factor). Vascular Pharmacology 2012;19:3-9
  353. Shimizu H, Nakagami H, Yasumasa N, Osako MK, Kyutoku M, Koriyama H, Nakagami F, Shimamura M, Rakugi H, Morishita R. Screening of anti-hypertensive drugs on osteoclastic acid secretion and bone resorption by acridine orange. Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry. 2012;12:161-167
  354. Iwabayashi M, Taniyama Y, Sanada F, Azuma J, Iekushi K, Okayama K, Kusunoki H, Amarnath Chatterjee, Rakugi H, Morishita R. Inhibition of Lp(a)-induced Impairment on Angiogenesis of Endothelial Cells and Endothelial Progenitor Cells by Hepatocyte Growth Factor. Biochemical and Biophysical Research Communications 2012;423:79-84
  355. Takeda S, Sato N, Yamada-Uchino K, Yu H, Moriguchi A, Rakugi H, Morishita R. Oral Glucose Loading Modulates Plasma Aβ Levels in Alzheimer Disease Patients: Potential Diagnosis Method of Alzheimer Disease. Dementia and Geriatric Cognitive Disorders 2012;34:25-30
  356. Huang CY, Lin FY, Shih CM, Au HK, Chang YJ, Nakagami H, Morishita R, Chang NC, Shyu KG, Chen JW. Moderate to High Concentrations of High Density Lipoprotein from Healthy Subjects Paradoxically Impair Human Endothelial Progenitor Cells and Related Angiogenesis by Activating Rho-associated Kinase Pathways. Arteriosclerosis, Thrombosis, & Vascular Biology 2012;32:2405-2417
  357. Makino H, Aoki M, Hashiya N, Yamasaki K, Azuma J, Sawa Y, Kaneda Y, Ogihara T, Morishita R. Long Term Follow Up Evaluation of Results From Clinical Trial (TREAT-HGF) Using Hepatocyte Growth Factor Gene to Treat Severe Peripheral Arterial Disease. Arteriosclerosis, Thrombosis, & Vascular Biology 2012;32:2503-2509
  358. Hayashi H, Nakagami H, Takeichi M, Shimamura M, Koibuchi N, Oiki E, Sato N, Koriyama H, Mori M, Araujo RG, Maeda A, Morishita R, Tamai K, Kaneda Y. HIG1, a novel regulator of mitochondrial γ-secretase, maintains normal mitochondrial function. FASEB Journal 2012;26:2306-2317
  359. Aoki T, Kataoka H, Nishimura M, Ishibashi R, Morishita R, Miyamoto S. Regression of Intracranial Aneurysms by Simultaneous Inhibition of NF-κB and Ets with Chimeric Decoy Oligodeoxynucleotide Treatment. Neurosurgery. 2012;70:1534-1543
  360. Chatterjee A, Kusunoki H, Taniyama Y, Rakugi H, Morishita R. Improvement of Metabolic Syndrome by Irbesartan via the PPARγ/HGF Pathway in Apolipoprotein E Knockout Mice. Biomedial Reports 2012;1:65-70
  361. Shimizu K, Taniyama Y, Sanada F, Iekushi K, Kyutoku M, Okayama K, Kusunoki H, Iwabayashi M, Azuma J, Morishita R. Hepatocyte Growth Factor Inhibits LPS-induced Oxidative Stress via Epithelial Growth Factor Receptor Degradation. Arteriosclerosis, Thrombosis, & Vascular Biology 2012;32:2687-2693
  362. Sato N, Okochi M, Shinohara M, Thinakaran G, Takeda S, Fukumori A, Shinohara-Noma M, Mori-Ueda M, Hamada H, Takeda M, Rakugi H, Morishita R. Differential Regulation of Amyloid Precursor Protein /Presenilin 1 Interaction during Aβ40/42 Production Detected Using Fusion Constructs. Plos ONE 2012;7(11):e48551. doi: 10.1371/journal.pone.0048551
  363. Ozaki K, Makino H, Miyake T, Yasumasa N, Osako MK, Nakagami H, Rakugi H, Morishita R. Therapeutic Effect of Ribbon Type NF-κB Decoy Oligonucleotides on Inflammatory Bowel Disease Model Rats. Current Gene Therapy 2012;12:484-492.
  364. Huang CY, Shih CM, Tsao NW, Lin YW, Huang PH, Wu SC, Lee AW, Kao YT, Chang NC, Nakagami H, Morishita R, Ou KL, Hou WC, Lin CY, Shyu KG, Lin FY. Dipeptidyl peptidase-4 inhibitor improves neovascularization by increasing circulating endothelial progenitor cells. British Journal of Pharmacology 2012;167:1506-1519. doi: 10.1111/j.1476-5381.2012.02102.x.
  365. Shimamura M, Sato N, Nakagami H, Osako MK, Kyutoku M, Wakayama K, Morishita R. Chronic Deposition of Aβ Influences Microcirculation in the Chronic Stage of Cerebral Ischemia. Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry 2013;13:77-80
  366. Shimizu K, Taniyama Y, Azuma J, Sanada F, Iwabayashi M, Yamane Y, Yamasaki H, Akasaka A, Morishita R. Evaluation of Pregabain Therapy in Peripheral Neuropathy. Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry 2013;13:132-138.
  367. Nakagami H, Shimosato T, Shimamura M, Morishita R. Rosuvastatin Ameriolates Obesity and Proteinuria in Zucker Diabtiec Fatty Rats. Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry 2013;13:144-149.
  368. Shimizu H, Nakagami H, Yasumasa N, Osako MK, Morishita R. Olmesartan Reduces Pentosidine Production and Maerilorate Fragility of Bone in Ovarectomized Fructose-Fed Rats. Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry 2013;13:150-158.
  369. Kusunoki H, Taniyama Y, Rakugi H, Morishita R. Cardiac and Renal Protective Effects of Irbesartan via PPARγ/Hepatocyte Growth Factor (HGF) Pathway Independent of AT1aR Blockade in Mouse Model of Salt-Sensitive Hypertension. Journal of American Heart Association 2013;2(2):e000103. doi: 10.1161/JAHA.113.000103
  370. Osako MK, Nakagami H, Shimamura M, Koriyama H, Nakagami F, Shimizu H, Miyake T, Yoshizumi M, Rakugi H, Kurinami H, Tomioka H, Morishita R. Cross-talk of RANKL signaling with Renin-Angiotensin System in Vascular Calcification. Arteriosclerosis, Thrombosis, & Vascular Biology 2013;33(6):1287-1296.
  371. Shimamura M, Nakagami H, Sata M, Takaoka M, Azuma J, Osako MK, Koriyama H, Kurinami H, Wakayama K, Miyake T, Morishita R. Unique Remodeling Processes after Vascular Injury in Intracranial Arteries: Analysis Using a Novel Mouse Model. Journal of Cerebral Blood Flow & Metabolism 2013;33:1153-1159
  372. Takeda S, Sato N, Ikimura K, Nishino H, Rakugi H, Morishita R. Increased Blood-Brain Barrier Vulnerability to Systemic Inflammation in Alzheimer Disease Mouse Model. Neurobiology of Aging 2013;34:2064-2070. doi: 10.1016/j.neurobiolaging.2013.02.010. Epub 2013 Apr 2.
  373. Kyutoku M, Nakagami H, Koriyama H, Nakagami F, Osako MK, Shimamura M, Kurinami H, Tomioka H, Miyake T, Morishita R. Inhibition of Neointima Formation by DNA Vaccine for Apolipoprotein(a): New Therapeutic Application of DNA Vaccine. Scientific Reports Sci Rep. 2013;3:1600. doi: 10.1038/srep01600.
  374. Nakagami F, Nakagami H, Koriyama H, Osako MK, Kyutoku M, Shimamura M, Miyake T, Katsuya T, Rakugi H, Morishita R. Decrease in Blood Pressure and Regression of Cardiovascular Complications by Angiotensin II Vaccine in Mice. Plos ONE 2013;8(3):e60493. doi: 10.1371/journal.pone.0060493.
  375. Rodriguez-Araujo G, Nakagami H, Hayashi H, Mori M, Shiuchi T, Minokoshi Y, Nakaoka Y, Takami Y, Komuro I, Morishita R, Kaneda Y. Alpha-synuclein elicits glucose uptake and utilization in adipocytes through the Gab1/PI3K/Akt transduction pathway. Cellular and Molecular Life Sciences. 2013;70:1123-1133. doi: 10.1007/s00018-012-1198-8.
  376. Kikuchi Y, Nakagami H, Katsuya T, Morishita R, Horio T, Kamide K, Miyata T, Kawano Y, Takami Y, Rakugi H, Kaneda Y, Ogihara T. Polymorphism of myospryn is associated with left ventricular diastolic dysfunction. Anti-aging Medicine (in press)
  377. Shimizu H, Nakagami H, Yasumasa N, Osako MK, Kyutoku M, Koriyama H, Nakagami F, Shimamura M, Rakugi H, Morishita R. Links between Hypertension and Osteoporosis Benidipine ameliorates osteoporosis in ovariectomized hypertensive rats through promotion of osteoblast proliferation and inhibition of osteoclast differentiation. Current Cardiovascular Risk Reports (in press)
  378. Kyutoku M, Nakagami H, Koriyama H, Tomioka H, Nakagami F, Shimamura M, Kurinami H, Zhengda P, Hyun JD, Kim JH, Takakura N, Morishita R. Development of novel DNA vaccine for VEGF in murine cancer model. Scientific Reports (in press)
  379. Shimamura M, Taniyama Y, Nakagami H, Katsuragi N, Wakayama K, Koriyama H, Kurinami H, Tenma A, Tomioka H, Morishita R. Long-term expression of periostin during the chronic stage of ischemic stroke in mice. Hypertension Research (in press)
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[Professor: Ryuichi Morishita]
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