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Cerebrovascular disease research group
(Division of Vascular Medicine and Epigenetics)


Original Articles

  1. Shimamura M, Taniyama Y, Katsuragi N, Koibuchi N , Kyutoku M, Sato N, Allahtavakoli M, Wakayama K, Nakagami H, Morishita R. Role of Central Periostin System in Cerebral. Stroke (in press)
  2. Shimamura M, Nakagami H, Shimosato T, Moritani T, Nakagami F, Osako M, Miyake T, Koriyama H, Shimizu H, and Morishita R. Improvement of Endothelial Dysfunction, Abnormal Lipid Profile, Proteinuria,and Liver Dysfunction by Irbesartan in Zucker Diabetic Fatty Rats Independent of Glucose and Insulin Levels. Experimental and Therapeutic Medicine (in press)
  3. Miyake T, Aoki M, Osako MK, Shimamura M, Nakagami H, Morishita R. Systemic Administration of Ribbon-type Decoy Oligodeoxynucleotide Against Nuclear Factor κB and Ets Prevents Abdominal Aortic Aneurysm in Rat Model. Mol Ther. 2011;19:181-187.
  4. Nakagami H, Kiomy Osako M, Nakagami F, Shimosato T, Minobe N, Moritani T, Shimamura M, Miyake T, Shimizu H, Takeya Y, Morishita R. Prevention and regression of non-alcoholic steatohepatitis (NASH) in a rat model by metabosartan, telmisartan.Int J Mol Med. 2010;26:477-481.
  5. Osako MK, Nakagami H, Koibuchi N, Shimizu H, Nakagami F, Koriyama H, Shimamura M, Miyake T, Rakugi H, Morishita R. Estrogen inhibits vascular calcification via vascular RANKL system: common mechanism of osteoporosis and vascular calcification. Circ Res. 2010;107:466-475.
  6. Shinohara M, Sato N, Kurinami H, Takeuchi D, Takeda S, Shimamura M, Yamashita T, Uchiyama Y, Rakugi H, Morishita R. Reduction of brain beta-amyloid (Abeta) by fluvastatin, a hydroxymethylglutaryl-CoA reductase inhibitor, through increase in degradation of amyloid precursor protein C-terminal fragments (APP-CTFs) and Abeta clearance. J Biol Chem. 2010;285:22091-22102.
  7. Nakagami F, Nakagami H, Osako MK, Iwabayashi M, Taniyama Y, Doi T, Shimizu H, Shimamura M, Rakugi H, Morishita R. Estrogen attenuates vascular remodeling in Lp(a) transgenic mice. Atherosclerosis. 2010;211:41-47
  8. Abe T, Shimamura M, Jackman K, Kurinami H, Anrather J, Zhou P, Iadecola C. Key role of CD36 in toll-like receptor 2 signaling in cerebral ischemia. Stroke. 2010;41:898-904
  9. Abe T, Kunz A, Shimamura M, Zhou P, Anrather J, Iadecola C. The neuroprotective effect of prostaglandin e2 ep1 receptor inhibition has a wide therapeutic window, is sustained in time and is not sexually dimorphic. J Cereb Blood Flow Metab. 2009;29:66-72
  10. Wakayama K, Shimamura M, Sata M, Koibuchi N, Sato N, Ogihara T, Morishita R. A model of cerebrovascular injury in rats. J Neurosci Methods. 2008;175:187-195
  11. Takeuchi D, Sato N, Shimamura M, Kurinami H, Takeda S, Shinohara M, Suzuki S, Kojima M, Ogihara T, Morishita R. Alleviation of abeta-induced cognitive impairment by ultrasound-mediated gene transfer of hgf in a mouse model. Gene Ther. 2008;15:561-571
  12. Kurinami H, Sato N, Shinohara M, Takeuchi D, Takeda S, Shimamura M, Ogihara T, Morishita R. Prevention of amyloid beta-induced memory impairment by fluvastatin, associated with the decrease in amyloid beta accumulation and oxidative stress in amyloid beta injection mouse model. Int J Mol Med. 2008;21:531-537
  13. Kunz A, Abe T, Hochrainer K, Shimamura M, Anrather J, Racchumi G, Zhou P, Iadecola C. Nuclear factor-kappab activation and postischemic inflammation are suppressed in cd36-null mice after middle cerebral artery occlusion. J Neurosci. 2008;28:1649-1658
  14. Wakayama K, Shimamura M, Sata M, Sato N, Kawakami K, Fukuda H, Tomimatsu T, Ogihara T, Morishita R. Quantitative measurement of neurological deficit after mild (30 min) transient middle cerebral artery occlusion in rats. Brain Res. 2007;1130:181-187
  15. Shimamura M, Sato N, Sata M, Wakayama K, Ogihara T, Morishita R. Expression of hepatocyte growth factor and c-met after spinal cord injury in rats. Brain Res. 2007;1151:188-194
  16. Shimamura M, Sato N, Sata M, Kurinami H, Takeuchi D, Wakayama K, Hayashi T, Iida H, Morishita R. Delayed postischemic treatment with fluvastatin improved cognitive impairment after stroke in rats. Stroke. 2007;38:3251-3258
  17. Aoki T, Kataoka H, Shimamura M, Nakagami H, Wakayama K, Moriwaki T, Ishibashi R, Nozaki K, Morishita R, Hashimoto N. Nf-kappab is a key mediator of cerebral aneurysm formation. Circulation. 2007;116:2830-2840
  18. Shimamura M, Sato N, Waguri S, Uchiyama Y, Hayashi T, Iida H, Nakamura T, Ogihara T, Kaneda Y, Morishita R. Gene transfer of hepatocyte growth factor gene improves learning and memory in the chronic stage of cerebral infarction. Hypertension. 2006;47:742-751
  19. Sato N, Okochi M, Taniyama Y, Kurinami H, Shimamura M, Takeuchi D, Hamada H, Fukumori A, Kiyosue K, Taguchi T, Tanaka T, Miyasaka M, Takeda M, Ogihara T, Morishita R. Development of new screening system for alzheimer disease, in vitro abeta sink assay, to identify the dissociation of soluble abeta from fibrils. Neurobiol Dis. 2006;22:487-495
  20. Koike H, Ishida A, Shimamura M, Mizuno S, Nakamura T, Ogihara T, Kaneda Y, Morishita R. Prevention of onset of parkinson's disease by in vivo gene transfer of human hepatocyte growth factor in rodent model: A model of gene therapy for parkinson's disease. Gene Ther. 2006;13:1639-1644
  21. Shimamura M, Sato N, Taniyama Y, Kurinami H, Tanaka H, Takami T, Ogihara T, Tohyama M, Kaneda Y, Morishita R. Gene transfer into adult rat spinal cord using naked plasmid DNA and ultrasound microbubbles. J Gene Med. 2005;7:1468-1474
  22. Shimamura M, Sato N, Taniyama Y, Yamamoto S, Endoh M, Kurinami H, Aoki M, Ogihara T, Kaneda Y, Morishita R. Development of efficient plasmid DNA transfer into adult rat central nervous system using microbubble-enhanced ultrasound. Gene Ther. 2004;11:1532-1539
  23. Shimamura M, Sato N, Oshima K, Aoki M, Kurinami H, Waguri S, Uchiyama Y, Ogihara T, Kaneda Y, Morishita R. Novel therapeutic strategy to treat brain ischemia: Overexpression of hepatocyte growth factor gene reduced ischemic injury without cerebral edema in rat model. Circulation. 2004;109:424-431
  24. Oshima K, Shimamura M, Mizuno S, Tamai K, Doi K, Morishita R, Nakamura T, Kubo T, Kaneda Y. Intrathecal injection of hvj-e containing hgf gene to cerebrospinal fluid can prevent and ameliorate hearing impairment in rats. FASEB J. 2004;18:212-214
  25. Shimamura M, Morishita R, Endoh M, Oshima K, Aoki M, Waguri S, Uchiyama Y, Kaneda Y. Hvj-envelope vector for gene transfer into central nervous system. Biochem Biophys Res Commun. 2003;300:464-471
  26. Sasaki R, Ito N, Shimamura M, Murakami T, Kuzuhara S, Uchino M, Uyama E. A novel clcn1 mutation: P480t in a japanese family with thomsen's myotonia congenita. Muscle Nerve. 2001;24:357-363
  27. Shimamura M, Uyama E, Hirano T, Murakami T, Mita S, Kitamoto T, Uchino M. A unique case of sporadic Creutzfeldt-Jacob disease presenting as progressive supranuclear palsy. Intern Med. 2003;42:195-8.
  28. Shimamura M, Uchida Y, Terasaki T, Hashimoto Y, Yamasaki H, Tsuda H, Wakayama T, Ando T, Uchino M. Hodgkin's disease preceded by unique neurological symptoms. Intern Med. 2001;40:819-21.


  1. Shimamura M, Sato N, Morishita R. Experimental and clinical application of plasmid DNA in the field of central nervous diseases.Curr Gene Ther. in publication.
  2. Shimamura M, Morishita R. Naked plasmid DNA for gene therapy. Curr Gene Ther. in publication.
  3. Shimamura M, Sato N, Taniyama Y, Kunugiza Y, Nakagami H, Morishita R. Ultrasound microbubbles and needleless jet injector for gene transfer of naked plasmid DNA. Nova Science Publishers, in publication
  4. Shimamura M, Sato N, Yoshimura S, Kaneda Y, Morishita R. HVJ-based non-viral gene transfer method: successful gene therapy using HGF and VEGF genes in experimental ischemia. Frontiers in bioscience : a journal and virtual library, Frontiers In Bioscience Publications; 2006;11:753-759
  5. Sato N, Shimamura M, Morishita R. Recent progress in cerebrovascular gene therapy. Current neurovascular research, Bentham Science Publishers;2005;2:235-247
[Cerebrovascular disease research group]
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